The Polo kinase Cdc5 is regulated at multiple levels in the adaptation response to telomere dysfunction [0.03%]
Polo激酶Cdc5在端粒功能障碍适应反应中的多水平调节
Héloïse Coutelier,Oana Ilioaia,Jeanne Le Peillet et al.
Héloïse Coutelier et al.
Telomere dysfunction activates the DNA damage checkpoint to induce a cell cycle arrest. After an extended period of time, however, cells can bypass the arrest and undergo cell division despite the persistence of the initial damage, a proces...
Expanded FLP toolbox for spatiotemporal protein degradation and transcriptomic profiling in Caenorhabditis elegans [0.03%]
用于Caenorhabditis elegans的时空蛋白质降解和转录组分析的扩展FLP工具箱
Adrián Fragoso-Luna,Raquel Romero-Bueno,Michael Eibl et al.
Adrián Fragoso-Luna et al.
Control of gene expression in specific tissues and/or at certain stages of development allows the study and manipulation of gene function with high precision. Site-specific genome recombination by the flippase (FLP) and cyclization recombin...
Effect of all-but-one conditional analysis for eQTL isolation in peripheral blood [0.03%]
全条件分析法在隔离外周血eQTL中的效应
Margaret Brown,Emily Greenwood,Biao Zeng et al.
Margaret Brown et al.
Expression quantitative trait locus detection has become increasingly important for understanding how noncoding variants contribute to disease susceptibility and complex traits. The major challenges in expression quantitative trait locus fi...
Multiple solutions at the genomic level in response to selective breeding for high locomotor activity [0.03%]
高运动活动性选择育种的基因组水平上的多解现象
David A Hillis,Theodore Garland
David A Hillis
Replicate lines under uniform selection often evolve in different ways. Previously, analyses using whole-genome sequence data for individual mice (Mus musculus) from 4 replicate High Runner lines and 4 nonselected control lines demonstrated...
AGO1 and HSP90 buffer different genetic variants in Arabidopsis thaliana [0.03%]
AGO1和HSP90以不同的方式缓冲拟南芥中的遗传变异
Tzitziki Lemus,Grace Alex Mason,Kerry L Bubb et al.
Tzitziki Lemus et al.
Argonaute 1 (AGO1), the principal protein component of microRNA-mediated regulation, plays a key role in plant growth and development. AGO1 physically interacts with the chaperone HSP90, which buffers cryptic genetic variation in plants and...
The effect of repeat length on Marcal1-dependent single-strand annealing in Drosophila [0.03%]
重复长度对果蝇Marcal1依赖的单链退火的影响
Evan B Dewey,Julie Korda Holsclaw,Kiyarash Saghaey et al.
Evan B Dewey et al.
Proper repair of DNA double-strand breaks is essential to the maintenance of genomic stability and avoidance of genetic disease. Organisms have many ways of repairing double-strand breaks, including the use of homologous sequences through h...
Endosperm and Maternal-specific expression of EIN2 in the endosperm affects endosperm cellularization and seed size in Arabidopsis [0.03%]
种子中胚乳和母体特异的EIN2表达影响拟南芥中胚乳细胞化及种子大小
Atsumi Ando,Ryan C Kirkbride,Hong Qiao et al.
Atsumi Ando et al.
Seed size is related to plant evolution and crop yield and is affected by genetic mutations, imprinting, and genome dosage. Imprinting is a widespread epigenetic phenomenon in mammals and flowering plants. ETHYLENE INSENSITIVE2 (EIN2) encod...
A large genome-wide association study of QT interval length utilizing electronic health records [0.03%]
一项基于电子健康记录的关于QT间期长度的大规模全基因组关联研究
Thomas J Hoffmann,Meng Lu,Akinyemi Oni-Orisan et al.
Thomas J Hoffmann et al.
QT interval length is an important risk factor for adverse cardiovascular outcomes; however, the genetic architecture of QT interval remains incompletely understood. We conducted a genome-wide association study of 76,995 ancestrally diverse...
Meta-Analysis
Genetics. 2022 Nov 30;222(4):iyac157. DOI:10.1093/genetics/iyac157 2022
Lagging X chromatids specify the orientation of asymmetric organelle partitioning in XX spermatocytes of Auanema rhodensis [0.03%]
Auanema rhodensis XX次级精母细胞中X染色体指定不对称器官分离的方向
Talal Al-Yazeedi,Emily L Xu,Jasmin Kaur et al.
Talal Al-Yazeedi et al.
The unequal partitioning of molecules and organelles during cell division results in daughter cells with different fates. An extreme example is female meiosis, in which consecutive asymmetric cell divisions give rise to 1 large oocyte and 2...
Opening up Peer Review [0.03%]
开放同行评审
Tracey A DePellegrin,Mark Johnston
Tracey A DePellegrin