Specific heparan sulfate modifications stabilize the synaptic organizer MADD-4/Punctin at Caenorhabditis elegans neuromuscular junctions [0.03%]
特定的肝素硫酸盐修饰稳定了秀丽隐杆线虫神经肌肉突触组织者MADD-4/Punctin
Mélissa Cizeron,Laure Granger,Hannes E Bülow et al.
Mélissa Cizeron et al.
Heparan sulfate (HS) proteoglycans contribute to the structural organization of various neurochemical synapses. Depending on the system, their role involves either the core protein or the glycosaminoglycan chains. These linear sugar chains ...
Rapid detection of inter-clade recombination in SARS-CoV-2 with Bolotie [0.03%]
用于SARS-CoV-2跨谱系重组快速检测的Bolotie方法
Ales Varabyou,Christopher Pockrandt,Steven L Salzberg et al.
Ales Varabyou et al.
The ability to detect recombination in pathogen genomes is crucial to the accuracy of phylogenetic analysis and consequently to forecasting the spread of infectious diseases and to developing therapeutics and public health policies. However...
Steroid hormone pathways coordinate developmental diapause and olfactory remodeling in Pristionchus pacificus [0.03%]
皮质醇激素信号途径协调刻齿赤虫的发育休眠和嗅觉重塑反应
Heather R Carstensen,Reinard M Villalon,Navonil Banerjee et al.
Heather R Carstensen et al.
Developmental and behavioral plasticity allow animals to prioritize alternative genetic programs during fluctuating environments. Behavioral remodeling may be acute in animals that interact with host organisms, since reproductive adults and...
An evolutionary genomic approach reveals both conserved and species-specific genetic elements related to human disease in closely related Aspergillus fungi [0.03%]
一种进化基因组方法揭示了与人类疾病相关的保守和物种特异性遗传元件在密切相关的曲霉属真菌中的情况
Matthew E Mead,Jacob L Steenwyk,Lilian P Silva et al.
Matthew E Mead et al.
Aspergillosis is an important opportunistic human disease caused by filamentous fungi in the genus Aspergillus. Roughly 70% of infections are caused by Aspergillus fumigatus, with the rest stemming from approximately a dozen other Aspergill...
Allele-specific suppression in Caenorhabditis elegans reveals details of EMS mutagenesis and a possible moonlighting interaction between the vesicular acetylcholine transporter and ERD2 receptors [0.03%]
利用杆状虫揭示EMT诱变的详细情况及其对囊泡乙酰胆碱转移蛋白和ERD2受体可能功能交叉作用的影响
Eleanor A Mathews,Dave Stroud,Gregory P Mullen et al.
Eleanor A Mathews et al.
A missense mutant, unc-17(e245), which affects the Caenorhabditis elegans vesicular acetylcholine transporter UNC-17, has a severe uncoordinated phenotype, allowing efficient selection of dominant suppressors that revert this phenotype to w...
Transposon-induced inversions activate gene expression in the maize pericarp [0.03%]
转座子诱导的倒位激活玉米果皮基因表达
Sharu Paul Sharma,Tao Zuo,Thomas Peterson
Sharu Paul Sharma
Chromosomal inversions can have considerable biological and agronomic impacts including disrupted gene function, change in gene expression, and inhibited recombination. Here, we describe the molecular structure and functional impact of six ...
Aline Muyle,Jeffrey Ross-Ibarra,Danelle K Seymour et al.
Aline Muyle et al.
In plants, mammals and insects, some genes are methylated in the CG dinucleotide context, a phenomenon called gene body methylation (gbM). It has been controversial whether this phenomenon has any functional role. Here, we took advantage of...
Kai Zeng,Brian Charlesworth,Asger Hobolth
Kai Zeng
Balancing selection (BLS) is the evolutionary force that maintains high levels of genetic variability in many important genes. To further our understanding of its evolutionary significance, we analyze models with BLS acting on a biallelic l...
Caenorhabditis elegans junctophilin has tissue-specific functions and regulates neurotransmission with extended-synaptotagmin [0.03%]
C-elegans 桥素蛋白具有组织特异功能并能与延长突触素调节神经递质释放
Christopher A Piggott,Zilu Wu,Stephen Nurrish et al.
Christopher A Piggott et al.
The junctophilin family of proteins tether together plasma membrane (PM) and endoplasmic reticulum (ER) membranes, and couple PM- and ER-localized calcium channels. Understanding in vivo functions of junctophilins is of great interest for d...
Genomic prediction of hybrid crops allows disentangling dominance and epistasis [0.03%]
基因组预测使杂交作物的显性和上位性解缠成为可能
David González-Diéguez,Andrés Legarra,Alain Charcosset et al.
David González-Diéguez et al.
We revisited, in a genomic context, the theory of hybrid genetic evaluation models of hybrid crosses of pure lines, as the current practice is largely based on infinitesimal model assumptions. Expressions for covariances between hybrids due...