Zebrafish spinal cord oligodendrocyte formation requires boc function [0.03%]
斑马鱼脊髓少突胶质细胞的形成需要boc基因的功能
Christina A Kearns,Macie Walker,Andrew M Ravanelli et al.
Christina A Kearns et al.
The axis of the vertebrate neural tube is patterned, in part, by a ventral to dorsal gradient of Shh signaling. In the ventral spinal cord, Shh induces concentration-dependent expression of transcription factors, subdividing neural progenit...
Characterizing dopaminergic neuron vulnerability using genome-wide analysis [0.03%]
利用全基因组分析阐述多巴胺神经元的脆弱性
Jacinta Davis,Claire Da Silva Santos,Narda Caudillo Zavala et al.
Jacinta Davis et al.
Parkinson's disease (PD) is primarily characterized by the loss of dopaminergic (DA) neurons in the brain. However, little is known about why DA neurons are selectively vulnerable to PD. To identify genes that are associated with DA neuron ...
Presynaptic Gαo (GOA-1) signals to depress command neuron excitability and allow stretch-dependent modulation of egg laying in Caenorhabditis elegans [0.03%]
C. 玖秀丽隐杆线虫指挥神经元的 presynaptic Gαo (GOA-1) 信号抑制作用及伸展依赖性调控产卵行为中的作用
Bhavya Ravi,Jian Zhao,Sana I Chaudhry et al.
Bhavya Ravi et al.
Egg laying in the nematode worm Caenorhabditis elegans is a two-state behavior modulated by internal and external sensory input. We have previously shown that homeostatic feedback of embryo accumulation in the uterus regulates bursting acti...
Analysis of Caenorhabditis elegans acetylcholine synthesis mutants reveals a temperature-sensitive requirement for cholinergic neuromuscular function [0.03%]
分析条纹秀丽隐杆线虫乙酰胆碱合成突变体揭示胆碱能神经肌肉功能的温度敏感性要求
Janet S Duerr,John R McManus,John A Crowell et al.
Janet S Duerr et al.
In Caenorhabditis elegans, the cha-1 gene encodes choline acetyltransferase (ChAT), the enzyme that synthesizes the neurotransmitter acetylcholine. We have analyzed a large number of cha-1 hypomorphic mutants, most of which are missense all...
Catalase inhibition by nitric oxide potentiates hydrogen peroxide to trigger catastrophic chromosome fragmentation in Escherichia coli [0.03%]
一氧化氮通过抑制过氧化氢酶增强过氧化氢效力以促使大肠杆菌染色体碎裂现象加重
Pooja Agashe,Andrei Kuzminov
Pooja Agashe
Hydrogen peroxide (H2O2, HP) is a universal toxin that organisms deploy to kill competing or invading cells. Bactericidal action of H2O2 presents several questions. First, the lethal H2O2 concentrations in bacterial cultures are 1000x highe...
In vivo tissue-specific chromatin profiling in Drosophila melanogaster using GFP-tagged nuclei [0.03%]
利用GFP标记细胞核在果蝇活体组织中进行染色质图谱分析
Juan Jauregui-Lozano,Kimaya Bakhle,Vikki M Weake
Juan Jauregui-Lozano
The chromatin landscape defines cellular identity in multicellular organisms with unique patterns of DNA accessibility and histone marks decorating the genome of each cell type. Thus, profiling the chromatin state of different cell types in...
shrunken4 is a mutant allele of ZmYSL2 that affects aleurone development and starch synthesis in maize [0.03%]
shrunk4是ZmYSL2的突变等位基因，影响玉米糊粉层发育和淀粉合成
Yonghui He,Qing Yang,Jun Yang et al.
Yonghui He et al.
Minerals are stored in the aleurone layer and embryo during maize seed development, but how they affect endosperm development and activity is unclear. Here, we cloned the gene underlying the classic maize kernel mutant shrunken4 (sh4) and f...
Proof of principle for piggyBac-mediated transgenesis in the flatworm Macrostomum lignano [0.03%]
利用piggyBac转座子介导的方法在扁虫Macrostomum lignano中进行转基因实验的概念验证
Kirill Ustyantsev,Jakub Wudarski,Igor Sukhikh et al.
Kirill Ustyantsev et al.
Regeneration-capable flatworms are informative research models to study the mechanisms of stem cell regulation, regeneration, and tissue patterning. The free-living flatworm Macrostomum lignano is currently the only flatworm where stable tr...
Parallel and population-specific gene regulatory evolution in cold-adapted fly populations [0.03%]
冷适应的果蝇群体中并行且特异的基因调控进化现象
Yuheng Huang,Justin B Lack,Grant T Hoppel et al.
Yuheng Huang et al.
Changes in gene regulation at multiple levels may comprise an important share of the molecular changes underlying adaptive evolution in nature. However, few studies have assayed within- and between-population variation in gene regulatory tr...
Environmentally contingent control of Candida albicans cell wall integrity by transcriptional regulator Cup9 [0.03%]
转录调节因子Cup9通过环境条件调控白色念珠菌的细胞壁完整性的机制研究
Yuichi Ichikawa,Vincent M Bruno,Carol A Woolford et al.
Yuichi Ichikawa et al.
The fungal pathogen Candida albicans is surrounded by a cell wall that is the target of caspofungin and other echinocandin antifungals. Candida albicans can grow in several morphological forms, notably budding yeast and hyphae. Yeast and hy...