Regionally specific and highly pleiotropic loci together mediate skeletal evolution in tropical and temperate house mice [0.03%]
热带和温带家鼠的骨骼进化是由具有高度多效性且区域特异性的遗传位点介导的
Sylvia M Durkin,Kathleen G Ferris,Mallory A Ballinger et al.
Sylvia M Durkin et al.
When organisms are exposed to new environments, they often evolve a suite of adaptive phenotypic changes. Understanding the genetic basis of these changes gives us insight into the factors that constrain and facilitate the process of adapta...
Keeping neurons in shape with fats: an educational primer for use with "Phospholipid biogenesis maintains neuronal integrity during aging and axon regeneration" [0.03%]
脂质“保持”神经元健康：兼作“磷脂合成维持神经元在衰老和轴突再生过程中的完整性”的教学小品文
Ryan J Lee,John P Vaughen
Ryan J Lee
Neurons assemble into breathtakingly intricate circuits that govern behavior and often perdure for life. How injured or aged neurons control their complex morphological connections to survive or perish remains an exciting and open question....
Hanbin Lee,Nathaniel S Pope,Jerome Kelleher et al.
Hanbin Lee et al.
Ancestral recombination graphs (ARGs) are an attractive means for quantitative genetic analysis of complex traits because they encode the realized genetic relatedness between a sample of individuals in the presence of genetic drift, recombi...
Non-cell autonomous miR-9a modulates female receptivity by constraining sensory neuron growth in Drosophila melanogaster [0.03%]
Drosophila miR-9a通过限制感觉神经元的生长跨细胞自主调节雌性接受度
Tianmu Zhang,Hongyu Miao,Joshua Bagley et al.
Tianmu Zhang et al.
Female Drosophila melanogaster undergo a dynamic transition in sexual behavior, shifting from high receptivity to active rejection of courting males. While this post-mating switch is well characterized, the molecular mechanisms governing th...
Selection for rapid embryonic development sculpted the new gene Shrew into an accelerator of Drosophila dorsal-ventral axis specification [0.03%]
胚胎发育的快速选择将新基因Shrew塑造成背腹轴模式形成的加速器
Sudhindra R Gadagkar,Stuart J Newfeld
Sudhindra R Gadagkar
Assignment of cell fate along the dorsal/ventral (D/V) axis of the Drosophila embryo occurs during the 40 minutes immediately prior to gastrulation. The mechanism is the rapid redistribution of Decapentaplegic-Screw morphogens from lateral ...
Crossover formation and coordinated assembly of synaptonemal complex relies on a direct interaction between Zip1 and Zip3 [0.03%]
重组交换及联会复合体的协调装配依赖Zip1和Zip3间的直接相互作用
Sabrina Sharmin,Karen Voelkel-Meiman,Alex J Poppel et al.
Sabrina Sharmin et al.
Several proteins collaborate to promote the crossover recombination events critical for accurate chromosome segregation during meiosis. How these "ZMM" factors (Zip2, Zip3, Zip4, Spo16, Mer3 and MutSγ) collaboratively function remains inco...
Methods for joint genetic prediction of multiple ordinal categorical and continuous traits [0.03%]
多有序分类性状和连续性状的联合基因预测方法
Matias Bermann,Andres Legarra,Ignacy Misztal et al.
Matias Bermann et al.
The landscape of animal and plant breeding is rapidly evolving. Companies now invest millions in collecting extensive data on health, disease, welfare, and fertility, which are key fitness traits relevant for sustainable production. Likewis...
Evolution of the rate, molecular spectrum, and fitness effects of mutation under minimal selection in Caenorhabditis elegans [0.03%]
在无选择压力条件下Caenorhabditis elegans突变率、分子光谱和适应值效应的演变
Sayran Saber,Md Monjurul Islam Rifat,Fahimeh Rahimi et al.
Sayran Saber et al.
The rate, molecular spectrum, and fitness effects of mutations vary at all levels of the biological hierarchy, from within individual genomes to among taxonomic domains. Understanding the evolutionary factors underpinning that variation is ...
Sexually dimorphic ATF4 expression in the fat confers female stress tolerance in Drosophila melanogaster [0.03%]
脂肪组织中性别二态性ATF4表达使雌性果蝇具有应激耐受能力
Lydia Grmai,Melissa Mychalczuk,Aditya Arkalgud et al.
Lydia Grmai et al.
Metabolic differences between males and females have been well documented across many species. However, the molecular basis of these differences and how they impact tolerance to nutrient deprivation is still under investigation. In this wor...
Michael E Goldberg,Harriet Dashnow,Kelley Harris et al.
Michael E Goldberg et al.
Short tandem repeats (STRs) are hotspots of genomic instability that mutate at rates orders of magnitude greater than non-repetitive loci due to frequent replication slippage. Expansions at some STR loci cause Mendelian diseases, while vari...