Mitochondrial perturbation reduces susceptibility to xenobiotics through altered efflux in Candida albicans [0.03%]
线粒体紊乱通过改变白念珠菌的外排而减少对异生物的敏感性
Saif Hossain,Amanda O Veri,Zhongle Liu et al.
Saif Hossain et al.
Candida albicans is a leading human fungal pathogen, which can cause superficial infections or life-threatening systemic disease in immunocompromised individuals. The ability to transition between yeast and filamentous forms is a major viru...
Maternal Piwi regulates primordial germ cell development to ensure the fertility of female progeny in Drosophila [0.03%]
Drosophila母体Piwi调节原始生殖细胞发育以确保雌性后代的生育能力
Lauren E Gonzalez,Xiongzhuo Tang,Haifan Lin
Lauren E Gonzalez
In many animals, germline development is initiated by proteins and RNAs that are expressed maternally. PIWI proteins and their associated small noncoding PIWI-interacting RNAs (piRNAs), which guide PIWI to target RNAs by base-pairing, are a...
Smoothened and ARL13B are critical in mouse for superior cerebellar peduncle targeting [0.03%]
SMO和ARL13B在小鼠中对于优势大脑脚投射是必不可少的
Sarah K Suciu,Alyssa B Long,Tamara Caspary
Sarah K Suciu
Patients with the ciliopathy Joubert syndrome present with physical anomalies, intellectual disability, and a hindbrain malformation described as the "molar tooth sign" due to its appearance on an MRI. This radiological abnormality results ...
A genetic titration of membrane composition in Caenorhabditis elegans reveals its importance for multiple cellular and physiological traits [0.03%]
利用基因滴定法研究芽殖酵母细胞膜组成对其多种细胞和生理特性的影响
Ranjan Devkota,Delaney Kaper,Rakesh Bodhicharla et al.
Ranjan Devkota et al.
Communicating editor: B. Grant The composition and biophysical properties of cellular membranes must be tightly regulated to maintain the proper functions of myriad processes within cells. To better understand the importance of membrane hom...
Parul Johri,Brian Charlesworth,Emma K Howell et al.
Parul Johri et al.
It has previously been shown that, conditional on its fixation, the time to fixation of a semi-dominant deleterious autosomal mutation in a randomly mating population is the same as that of an advantageous mutation. This result implies that...
WormPaths: Caenorhabditis elegans metabolic pathway annotation and visualization [0.03%]
WormPaths：秀丽隐杆线虫代谢途径注释与可视化
Melissa D Walker,Gabrielle E Giese,Amy D Holdorf et al.
Melissa D Walker et al.
In our group, we aim to understand metabolism in the nematode Caenorhabditis elegans and its relationships with gene expression, physiology, and the response to therapeutic drugs. Visualization of the metabolic pathways that comprise the me...
Kassi L Crocker,Khailee Marischuk,Stacey A Rimkus et al.
Kassi L Crocker et al.
Neurodegenerative diseases such as Alzheimer's and Parkinson's currently affect ∼25 million people worldwide. The global incidence of traumatic brain injury (TBI) is estimated at ∼70 million/year. Both neurodegenerative diseases and TBI r...
Neuronal postdevelopmentally acting SAX-7S/L1CAM can function as cleaved fragments to maintain neuronal architecture in Caenorhabditis elegans [0.03%]
神经元后发育作用的SAX-7S/L1CAM可以作为小片段发挥作用以维持秀丽隐杆线虫中的神经结构
Virginie E Desse,Cassandra R Blanchette,Malika Nadour et al.
Virginie E Desse et al.
Whereas remarkable advances have uncovered mechanisms that drive nervous system assembly, the processes responsible for the lifelong maintenance of nervous system architecture remain poorly understood. Subsequent to its establishment during...
Meta-analysis identifies pleiotropic loci controlling phenotypic trade-offs in sorghum [0.03%]
泛基因组分析鉴定出控制高粱表型trade-off的多效性位点
Ravi V Mural,Marcin Grzybowski,Chenyong Miao et al.
Ravi V Mural et al.
Community association populations are composed of phenotypically and genetically diverse accessions. Once these populations are genotyped, the resulting marker data can be reused by different groups investigating the genetic basis of differ...
Meta-Analysis
Genetics. 2021 Jul 14;218(3):iyab087. DOI:10.1093/genetics/iyab087 2021
Juraj Bergman,Mikkel Heide Schierup
Juraj Bergman
The nucleotide composition of the genome is a balance between the origin and fixation rates of different mutations. For example, it is well-known that transitions occur more frequently than transversions, particularly at CpG sites. Differen...