Sex differences in deleterious mutational effects in Drosophila melanogaster: combining quantitative and population genetic insights [0.03%]
果蝇中不利突变效应的性别差异：定量和群体遗传学视角的结合
Filip Ruzicka,Tim Connallon,Max Reuter
Filip Ruzicka
Fitness effects of deleterious mutations can differ between females and males due to: (i) sex differences in the strength of purifying selection; and (ii) sex differences in ploidy. Although sex differences in fitness effects have important...
UNC-16 alters DLK-1 localization and negatively regulates actin and microtubule dynamics in Caenorhabditis elegans regenerating neurons [0.03%]
UNC-16改变DLK-1定位并负向调控Caenorhabditis elegans再生神经元中肌动蛋白和微管的动态变化
Sucheta S Kulkarni,Vidur Sabharwal,Seema Sheoran et al.
Sucheta S Kulkarni et al.
Neuronal regeneration after injury depends on the intrinsic growth potential of neurons. Our study shows that UNC-16, a Caenorhabditis elegans JIP3 homolog, inhibits axonal regeneration by regulating initiation and rate of regrowth. This oc...
Differences in evolutionary accessibility determine which equally effective regulatory motif evolves to generate pulses [0.03%]
不同的进化可及性差异决定哪种同样有效的调控基序会进化以产生脉冲
Kun Xiong,Mark Gerstein,Joanna Masel
Kun Xiong
Transcriptional regulatory networks (TRNs) are enriched for certain "motifs." Motif usage is commonly interpreted in adaptationist terms, i.e., that the optimal motif evolves. But certain motifs can also evolve more easily than others. Here...
LD-CNV: rapid and simple discovery of chromosomal translocations using linkage disequilibrium between copy number variable loci [0.03%]
LD-CNV：利用拷贝数变异位点之间的连锁不平衡快速简单地发现染色体易位
Luca Comai,Kirk R Amundson,Benny Ordoñez et al.
Luca Comai et al.
Large-scale structural variations, such as chromosomal translocations, can have profound effects on fitness and phenotype, but are difficult to identify and characterize. Here, we describe a simple and effective method aimed at identifying ...
Patterns and mechanisms of sex ratio distortion in the Collaborative Cross mouse mapping population [0.03%]
协作交叉小鼠定位人群中性别比例失衡的模式和机制
Brett A Haines,Francesca Barradale,Beth L Dumont
Brett A Haines
In species with single-locus, chromosome-based mechanisms of sex determination, the laws of segregation predict an equal ratio of females to males at birth. Here, we show that departures from this Mendelian expectation are commonplace in th...
QTL mapping in outbred tetraploid (and diploid) diallel populations [0.03%]
杂交四倍体（和二倍体）品种间群体的数量性状位点定位研究
Rodrigo R Amadeu,Patricio R Muñoz,Chaozhi Zheng et al.
Rodrigo R Amadeu et al.
Over the last decade, multiparental populations have become a mainstay of genetics research in diploid species. Our goal was to extend this paradigm to autotetraploids by developing software for quantitative trait locus (QTL) mapping in con...
The pushback against state interference in science: how Lysenkoism tried to suppress Genetics and how it was eventually defeated [0.03%]
反对国家对科学的干预：李森科主义如何试图压制遗传学及其最终失败的故事
Vasily V Ptushenko
Vasily V Ptushenko
Genetics in the Soviet Union (USSR) achieved state-of-the-art results and had reached a peak of development by the mid-1930s due to the efforts of the scientific schools of several major figures, including Sergei Navashin, Nikolai Koltsov, ...
Overt and concealed genetic loads revealed by QTL mapping of genotype-dependent viability in the Pacific oyster Crassostrea gigas [0.03%]
太平洋牡蛎Crassostrea gigas基因型依赖性活力的QTL定位揭示了显性和隐性遗传负荷
Xiaoshen Yin,Dennis Hedgecock
Xiaoshen Yin
Understanding the genetic bases of inbreeding depression, heterosis, and genetic load is integral to understanding how genetic diversity is maintained in natural populations. The Pacific oyster Crassostrea gigas, like many long-lived plants...
An engineered, orthogonal auxin analog/AtTIR1(F79G) pairing improves both specificity and efficacy of the auxin degradation system in Caenorhabditis elegans [0.03%]
工程正交的生长素类似物/AtTIR1(F79G)配对可改进斑氏线虫中生长素降解系统的特异性和功效
Kelly Hills-Muckey,Michael A Q Martinez,Natalia Stec et al.
Kelly Hills-Muckey et al.
The auxin-inducible degradation system in C. elegans allows for spatial and temporal control of protein degradation via heterologous expression of a single Arabidopsis thaliana F-box protein, transport inhibitor response 1 (AtTIR1). In this...
Orthogonal CRISPR-Cas tools for genome editing, inhibition, and CRISPR recording in zebrafish embryos [0.03%]
斑马鱼胚胎中的基因编辑、抑制和CRISPR记录的正交CRISPR-Cas工具
Paige R Takasugi,Shengzhou Wang,Kimberly T Truong et al.
Paige R Takasugi et al.
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas universe continues to expand. The type II CRISPR-Cas system from Streptococcus pyogenes (SpyCas9) is the most widely used for genome editing due to its high efficien...