Arabidopsis OXIDATIVE STRESS 3 enhances stress tolerance in Schizosaccharomyces pombe by promoting histone subunit replacement that upregulates drug-resistant genes [0.03%]
拟南芥OXIDATIVE STRESS 3通过促进组蛋白亚基替代来上调抗药基因，从而增强薛化子囊酵母的耐受性
Dingwang Lai,Xiuting Huang,Changhu Wang et al.
Dingwang Lai et al.
Histone replacement in chromatin-remodeling plays an important role in eukaryotic gene expression. New histone variants replacing their canonical counterparts often lead to a change in transcription, including responses to stresses caused b...
Sachin Kaushik,Kavita Jain
Sachin Kaushik
Although many experimental and theoretical studies on natural selection have been carried out in a constant environment, as natural environments typically vary in time, it is important to ask if and how the results of these investigations a...
Replication timing analysis in polyploid cells reveals Rif1 uses multiple mechanisms to promote underreplication in Drosophila [0.03%]
多倍体细胞的复制时间分析揭示了Rif1在果蝇中使用多种机制来促进下复制
Souradip Das,Madison Caballero,Tatyana Kolesnikova et al.
Souradip Das et al.
Regulation of DNA replication and copy number is necessary to promote genome stability and maintain cell and tissue function. DNA replication is regulated temporally in a process known as replication timing (RT). Rap1-interacting factor 1 (...
A DREaMR system to simplify combining mutations with rescue transgenes in Aedes aegypti [0.03%]
一种简化蚊子中突变与救援转基因组合的DREaMR系统
Jieyan Chen,Junjie Luo,Adishthi S Gurav et al.
Jieyan Chen et al.
In most experimental animals, it is challenging to combine mutations and rescue transgenes and to use bipartite systems to assess gene expression. To circumvent the difficulties in combining multiple genetic elements, we developed the DREaM...
The Caenorhabditis elegans Patched domain protein PTR-4 is required for proper organization of the precuticular apical extracellular matrix [0.03%]
线虫补丁域蛋白PTR-4对于前角质层的顶外基质的正确构建是必需的
Jennifer D Cohen,Carla E Cadena Del Castillo,Nicholas D Serra et al.
Jennifer D Cohen et al.
The Patched-related superfamily of transmembrane proteins can transport lipids or other hydrophobic molecules across cell membranes. While the Hedgehog receptor Patched has been intensively studied, much less is known about the biological r...
An autoregulation loop in fust-1 for circular RNA regulation in Caenorhabditis elegans [0.03%]
线虫中环形RNA调控的fust-1自身调节回路
Dong Cao
Dong Cao
Many circular RNAs (circRNAs) are differentially expressed in different tissues or cell types, suggestive of specific factors that regulate their biogenesis. Here, taking advantage of available mutation strains of RNA-binding proteins (RBPs...
Necrosis-induced apoptosis promotes regeneration in Drosophila wing imaginal discs [0.03%]
坏死诱导的细胞凋亡促进果蝇翅膀原基再生
Jacob Klemm,Michael J Stinchfield,Robin E Harris
Jacob Klemm
Regeneration is a complex process that requires a coordinated genetic response to tissue loss. Signals from dying cells are crucial to this process and are best understood in the context of regeneration following programmed cell death, like...
hlh-12, a gene that is necessary and sufficient to promote migration of gonadal regulatory cells in Caenorhabditis elegans, evolved within the Caenorhabditis clade [0.03%]
hlh-12是在秀丽隐杆线虫中促进生殖腺调节细胞迁移的必要且充分的基因，在丝状支原体类中进化而来
Hana E Littleford,Karin Kiontke,David H A Fitch et al.
Hana E Littleford et al.
Specialized cells of the somatic gonad primordium of nematodes play important roles in the final form and function of the mature gonad. Caenorhabditis elegans hermaphrodites are somatic females that have a two-armed, U-shaped gonad that con...
Genomic mating in outbred species: predicting cross usefulness with additive and total genetic covariance matrices [0.03%]
非近交种群中的基因组选配：利用加性遗传和总遗传协方差矩阵预测杂交的效果
Marnin D Wolfe,Ariel W Chan,Peter Kulakow et al.
Marnin D Wolfe et al.
Diverse crops are both outbred and clonally propagated. Breeders typically use truncation selection of parents and invest significant time, land, and money evaluating the progeny of crosses to find exceptional genotypes. We developed and te...
Estimation of genetic variance contributed by a quantitative trait locus: correcting the bias associated with significance tests [0.03%]
估计定量性状位点所贡献的遗传变异：纠正与显著性检验相关的偏差
Fangjie Xie,Shibo Wang,William D Beavis et al.
Fangjie Xie et al.
The Beavis effect in quantitative trait locus (QTL) mapping describes a phenomenon that the estimated effect size of a statistically significant QTL (measured by the QTL variance) is greater than the true effect size of the QTL if the sampl...