Genome-wide association mapping of transcriptome variation in Mimulus guttatus indicates differing patterns of selection on cis- versus trans-acting mutations [0.03%]
毛地黄草中全基因组关联映射的转录变异指出顺式和反式作用突变选择的不同模式
Keely E Brown,John K Kelly
Keely E Brown
We measured the floral bud transcriptome of 151 fully sequenced lines of Mimulus guttatus from one natural population. Thousands of single nucleotide polymorphisms (SNPs) are implicated as transcription regulators, but there is a striking d...
Transmission distortion and genetic incompatibilities between alleles in a multigenerational mouse advanced intercross line [0.03%]
多代小鼠高级互交群中等位基因之间的传递扭曲和遗传不兼容性
Danny Arends,Stefan Kärst,Sebastian Heise et al.
Danny Arends et al.
While direct additive and dominance effects on complex traits have been mapped repeatedly, additional genetic factors contributing to the heterogeneity of complex traits have been scarcely investigated. To assess genetic background effects,...
The disease-associated proteins Drosophila Nab2 and Ataxin-2 interact with shared RNAs and coregulate neuronal morphology [0.03%]
与疾病相关的蛋白黑腹果蝇Nab2和Ataxin-2相互作用于共享的RNAs并共同调节神经元形态
J Christopher Rounds,Edwin B Corgiat,Changtian Ye et al.
J Christopher Rounds et al.
Nab2 encodes the Drosophila melanogaster member of a conserved family of zinc finger polyadenosine RNA-binding proteins (RBPs) linked to multiple steps in post-transcriptional regulation. Mutation of the Nab2 human ortholog ZC3H14 gives ris...
A motor independent requirement for dynein light chain in Caenorhabditis elegans meiotic synapsis [0.03%]
秀丽隐杆线虫减数分裂联会中对动力蛋白轻链的电机独立需求
Sara M Fielder,Tori Kent,Huiping Ling et al.
Sara M Fielder et al.
The dynein motor complex is thought to aid in homolog pairing in many organisms by moving chromosomes within the nuclear periphery to promote and test homologous interactions. This precedes synaptonemal complex (SC) formation during homolog...
Insulin signaling and osmotic stress response regulate arousal and developmental progression of C. elegans at hatching [0.03%]
胰岛素信号和渗透压应激响应调节秀丽隐杆线虫在孵化时的唤醒及发育进程
Emily A Bayer,Katarina M Liberatore,Jordan R Schneider et al.
Emily A Bayer et al.
The progression of animal development from embryonic to juvenile life depends on the coordination of organism-wide responses with environmental conditions. We found that two transcription factors that function in interneuron differentiation...
Phylogenomic approaches to detecting and characterizing introgression [0.03%]
系统基因组学方法在检测和描述渗入杂交中的应用
Mark S Hibbins,Matthew W Hahn
Mark S Hibbins
Phylogenomics has revealed the remarkable frequency with which introgression occurs across the tree of life. These discoveries have been enabled by the rapid growth of methods designed to detect and characterize introgression from whole-gen...
Ole F Christensen,Vinzent Börner,Luis Varona et al.
Ole F Christensen et al.
Published Erratum
Genetics. 2021 Dec 10;219(4):iyab167. DOI:10.1093/genetics/iyab167 2021
The F-box protein Bard (CG14317) targets the Smaug RNA-binding protein for destruction during the Drosophila maternal-to-zygotic transition [0.03%]
F框蛋白Bard（CG14317）在果蝇母体到合子转变过程中降解Smaug RNA结合蛋白
Wen Xi Cao,Angelo Karaiskakis,Sichun Lin et al.
Wen Xi Cao et al.
During the maternal-to-zygotic transition (MZT), which encompasses the earliest stages of animal embryogenesis, a subset of maternally supplied gene products is cleared, thus permitting activation of zygotic gene expression. In the Drosophi...
Differential effects of two catalytic mutations on full-length PRDM9 and its isolated PR/SET domain reveal a case of pseudomodularity [0.03%]
两种催化突变对全长PRDM9及其隔离的PR / SET域的不同影响揭示了一个伪模块的例子
Natalie R Powers,Timothy Billings,Kenneth Paigen et al.
Natalie R Powers et al.
PRDM9 is a DNA-binding histone methyltransferase that designates and activates recombination hotspots in mammals by locally trimethylating lysines 4 and 36 of histone H3. In mice, we recently reported two independently produced point mutati...
A conserved behavioral role for a nematode interneuron neuropeptide receptor [0.03%]
一种线虫中间神经肽受体的保守行为功能
Cynthia M Chai,Wen Chen,Wan-Rong Wong et al.
Cynthia M Chai et al.
Neuropeptides are evolutionarily conserved modulators of many aspects of animal behavior and physiology, and expand the repertoire of processes that can be controlled by a limited number of neurons. Deciphering the neuropeptidergic codes th...