The STRIPAK component SipC is involved in morphology and cell-fate determination in the nematode-trapping fungus Duddingtonia flagrans [0.03%]
STRIPAK组分SipC参与捕食线虫真菌Duddingtonia flagrans的形态和细胞命运决定过程
Valentin Wernet,Jan Wäckerle,Reinhard Fischer
Valentin Wernet
The striatin-interacting phosphatase and kinase (STRIPAK) complex is a highly conserved eukaryotic signaling hub involved in the regulation of many cellular processes. In filamentous fungi, STRIPAK controls multicellular development, hyphal...
Pleiotropy or linkage? Their relative contributions to the genetic correlation of quantitative traits and detection by multitrait GWA studies [0.03%]
多效性还是连锁？它们对数量性状遗传相关的相对贡献及通过多特征全基因组关联研究的检测
Jobran Chebib,Frédéric Guillaume
Jobran Chebib
Genetic correlations between traits may cause correlated responses to selection. Previous models described the conditions under which genetic correlations are expected to be maintained. Selection, mutation, and migration are all proposed to...
Blm helicase facilitates rapid replication of repetitive DNA sequences in early Drosophila development [0.03%]
BLM解旋酶促进早期果蝇发育中重复DNA序列的快速复制
Jolee M Ruchert,Morgan M Brady,Susan McMahan et al.
Jolee M Ruchert et al.
The absence of functional BLM DNA helicase, a member of the RecQ family of helicases, is responsible for the rare human disorder Bloom Syndrome, which results in developmental abnormalities, DNA repair defects, genomic instability, and a pr...
Genetic analysis of Hsp90 function in Cryptococcus neoformans highlights key roles in stress tolerance and virulence [0.03%]
Hsp90在新型隐球菌中功能的基因分析突显其在抗应力和致病性中的关键作用
Ci Fu,Sarah R Beattie,Andrew J Jezewski et al.
Ci Fu et al.
The opportunistic human fungal pathogen Cryptococcus neoformans has tremendous impact on global health, causing 181,000 deaths annually. Current treatment options are limited, and the frequent development of drug resistance exacerbates the ...
Robust Cre recombinase activity in the biotrophic smut fungus Ustilago maydis enables efficient conditional null mutants in planta [0.03%]
生物锈菌Ustilago maydis中稳健的Cre重组酶活性可实现植物中的高效条件性突变体
Antonio de la Torre,Matteo Jurca,Kai Hoffmann et al.
Antonio de la Torre et al.
Site-specific recombinases have been used in higher eukaryotes, especially in animals, for a broad range of applications, including chromosomal translocations, large deletions, site-specific integration, and tissue-specific as well as condi...
The sixth transmembrane region of a pheromone G-protein coupled receptor, Map3, is implicated in discrimination of closely related pheromones in Schizosaccharomyces pombe [0.03%]
第六跨膜区信息素G蛋白偶联受体Map3参与薛氏肺囊菌中结构相似的信息素的识别
Taisuke Seike,Natsue Sakata,Chikashi Shimoda et al.
Taisuke Seike et al.
Most sexually reproducing organisms have the ability to recognize individuals of the same species. In ascomycete fungi including yeasts, mating between cells of opposite mating type depends on the molecular recognition of two peptidyl matin...
Identification of Mep1a as a susceptibility gene for atherosclerosis in mice [0.03%]
鉴定Mep1a小鼠动脉粥样硬化的易感基因
Andrew T Grainger,Nathanael Pilar,Jun Li et al.
Andrew T Grainger et al.
Atherosclerosis is the underlying cause of heart attack, ischemic stroke and peripheral arterial disease, and genetic factors involved remain mostly unidentified. We previously identified a significant locus on mouse chromosome 17 for ather...
Evolved Bmp6 enhancer alleles drive spatial shifts in gene expression during tooth development in sticklebacks [0.03%]
进化的Bmp6增强子等位基因导致在刺鱼牙齿发育过程中基因表达的空间变动
Mark D Stepaniak,Tyler A Square,Craig T Miller
Mark D Stepaniak
Mutations in enhancers have been shown to often underlie natural variation but the evolved differences in enhancer activity can be difficult to identify in vivo. Threespine sticklebacks (Gasterosteus aculeatus) are a robust system for study...
The quantitative genetics of the prevalence of infectious diseases: hidden genetic variation due to indirect genetic effects dominates heritable variation and response to selection [0.03%]
传染病流行量化的遗传学：由于间接遗传效应导致的隐藏遗传变异主导了可遗传变异和选择反应
Piter Bijma,Andries D Hulst,Mart C M de Jong
Piter Bijma
Infectious diseases have profound effects on life, both in nature and agriculture. However, a quantitative genetic theory of the host population for the endemic prevalence of infectious diseases is almost entirely lacking. While several stu...