Two promoters integrate multiple enhancer inputs to drive wild-type knirps expression in the Drosophila melanogaster embryo [0.03%]
两个启动子整合多个增强子输入以在黑腹果蝇胚胎中驱动野生型knirps基因的表达
Lily Li,Rachel Waymack,Mario Gad et al.
Lily Li et al.
Proper development depends on precise spatiotemporal gene expression patterns. Most developmental genes are regulated by multiple enhancers and often by multiple core promoters that generate similar transcripts. We hypothesize that multiple...
Translational control of lipogenesis links protein synthesis and phosphoinositide signaling with nuclear division in Saccharomyces cerevisiae [0.03%]
脂肪生成的翻译控制将蛋白质合成和磷脂酰肌醇信号转导与酿酒酵母中的核分裂联系起来
Nairita Maitra,Staci Hammer,Clara Kjerfve et al.
Nairita Maitra et al.
Continuously dividing cells coordinate their growth and division. How fast cells grow in mass determines how fast they will multiply. Yet, there are few, if any, examples of a metabolic pathway that actively drives a cell cycle event instea...
The zinc cluster transcription factor Rha1 is a positive filamentation regulator in Candida albicans [0.03%]
锌指转录因子Rha1是在白色念珠菌中的一种正向丝状生长调节因子
Raha Parvizi Omran,Bernardo Ramírez-Zavala,Walters Aji Tebung et al.
Raha Parvizi Omran et al.
Zinc cluster transcription factors (TFs) are essential fungal regulators of gene expression. In the pathogen Candida albicans, the gene orf19.1604 encodes a zinc cluster TF regulating filament development. Hyperactivation of orf19.1604, whi...
Sporadic occurrence of recent selective sweeps from standing variation in humans as revealed by an approximate Bayesian computation approach [0.03%]
揭示人类近期选择性清除现象的近似贝叶斯计算方法中的间歇发生情况
Guillaume Laval,Etienne Patin,Pierre Boutillier et al.
Guillaume Laval et al.
During their dispersals over the last 100,000 years, modern humans have been exposed to a large variety of environments, resulting in genetic adaptation. While genome-wide scans for the footprints of positive Darwinian selection have increa...
Genetic architecture modulates diet-induced hepatic mRNA and miRNA expression profiles in Diversity Outbred mice [0.03%]
遗传体系结构调节多样性杂交小鼠饮食引起的肝mRNA和miRNA表达谱
Excel Que,Kristen L James,Alisha R Coffey et al.
Excel Que et al.
Genetic approaches in model organisms have consistently demonstrated that molecular traits such as gene expression are under genetic regulation, similar to clinical traits. The resulting expression quantitative trait loci (eQTL) have revolu...
Disentangling genetic feature selection and aggregation in transcriptome-wide association studies [0.03%]
转录组范围关联研究中遗传特征选择和聚集的分离解析
Chen Cao,Pathum Kossinna,Devin Kwok et al.
Chen Cao et al.
The success of transcriptome-wide association studies (TWAS) has led to substantial research toward improving the predictive accuracy of its core component of genetically regulated expression (GReX). GReX links expression information with g...
An extracellular matrix damage sensor signals through membrane-associated kinase DRL-1 to mediate cytoprotective responses in Caenorhabditis elegans [0.03%]
一种通过与膜相关联的激酶DRL-1传递信号来介导细胞保护反应的胞外基质损伤传感器在秀丽隐杆线虫中的作用
Keon Wimberly,Keith P Choe
Keon Wimberly
We and others previously identified circumferential bands of collagen named annular furrows as key components of a damage sensor in the cuticle of Caenorhabditis elegans that regulates cytoprotective genes. Mutation or loss of noncollagen s...
Corrigendum to: Chemosensory signal transduction in Caenorhabditis elegans [0.03%]
Caenorhabditis elegans中的化学感觉信号转导 的勘误表
Denise M Ferkey,Piali Sengupta,Noelle D L&#x;Etoile
Denise M Ferkey
Published Erratum
Genetics. 2022 Jan 4;220(1):iyab181. DOI:10.1093/genetics/iyab181 2022
Gene network simulations provide testable predictions for the molecular domestication syndrome [0.03%]
基因网络模拟为分子驯化综合症提供了可检验的预测
Ewen Burban,Maud I Tenaillon,Arnaud Le Rouzic
Ewen Burban
The domestication of plant species leads to repeatable morphological evolution, often referred to as the phenotypic domestication syndrome. Domestication is also associated with important genomic changes, such as the loss of genetic diversi...