Reconstruction of human genome evolution in yeast: an educational primer for use with "systematic humanization of the yeast cytoskeleton discerns functionally replaceable from divergent human genes" [0.03%]
酵母中人类基因组进化的重建：“系统地人源化酵母细胞骨架，以区分功能可替代和发散的人类基因”的教育入门指南
Zuzana Brzáčová,Mária Peťková,Katarína Veljačiková et al.
Zuzana Brzáčová et al.
The evolution of eukaryotic organisms starting with the last eukaryotic common ancestor was accompanied by lineage-specific expansion of gene families. A paper by Garge et al. provides an excellent opportunity to have students explore how e...
Synergistic roles of homeodomain proteins UNC-62 homothorax and MLS-2 HMX/NKX in the specification of olfactory neurons in Caenorhabditis elegans [0.03%]
同源域蛋白在秀丽隐杆线虫嗅觉神经元分化中的协同作用
Yi-Wen Hsieh,Rui Xiong,Chiou-Fen Chuang
Yi-Wen Hsieh
General identity of the Caenorhabditis elegans AWC olfactory neuron pair is specified by the OTX/OTD transcription factor CEH-36 and the HMG-box transcription factor SOX-2, followed by asymmetrical differentiation of the pair into two disti...
Mitochondrial mutations in Caenorhabditis elegans show signatures of oxidative damage and an AT-bias [0.03%]
线虫中的线粒体突变显示出氧化损伤的特征并倾向于AT碱基对
Gus Waneka,Joshua M Svendsen,Justin C Havird et al.
Gus Waneka et al.
Rapid mutation rates are typical of mitochondrial genomes (mtDNAs) in animals, but it is not clear why. The difficulty of obtaining measurements of mtDNA mutation that are not biased by natural selection has stymied efforts to distinguish b...
Megan M Colonnetta,Juan E Abrahante,Paul Schedl et al.
Megan M Colonnetta et al.
Embryonic patterning is critically dependent on zygotic genome activation (ZGA). In Drosophila melanogaster embryos, the pioneer factor Zelda directs ZGA, possibly in conjunction with other factors. Here, we have explored the novel involvem...
Ole F Christensen,Vinzent Börner,Luis Varona et al.
Ole F Christensen et al.
In animal and plant breeding and genetics, there has been an increasing interest in intermediate omics traits, such as metabolomics and transcriptomics, which mediate the effect of genetics on the phenotype of interest. For inclusion of suc...
The SAGA and NuA4 component Tra1 regulates Candida albicans drug resistance and pathogenesis [0.03%]
SAGA和NuA4组分Tra1调节白念珠菌的药物抗性和病原性
Iqra Razzaq,Matthew D Berg,Yuwei Jiang et al.
Iqra Razzaq et al.
Candida albicans is the most common cause of death from fungal infections. The emergence of resistant strains reducing the efficacy of first-line therapy with echinocandins, such as caspofungin calls for the identification of alternative th...
Yeast J-protein Sis1 prevents prion toxicity by moderating depletion of prion protein [0.03%]
酵母J蛋白Sis1通过适度降低朊病毒蛋白来防止朊病毒毒性
Jyotsna Kumar,Michael Reidy,Daniel C Masison
Jyotsna Kumar
[PSI+] is a prion of Saccharomyces cerevisiae Sup35, an essential ribosome release factor. In [PSI+] cells, most Sup35 is sequestered into insoluble amyloid aggregates. Despite this depletion, [PSI+] prions typically affect viability only m...
Rad9-mediated checkpoint activation is responsible for elevated expansions of GAA repeats in CST-deficient yeast [0.03%]
RAD9介导的检查点激活负责CST缺陷酵母中GAA重复序列的扩增增加
Ekaterina Spivakovsky-Gonzalez,Erica J Polleys,Chiara Masnovo et al.
Ekaterina Spivakovsky-Gonzalez et al.
Large-scale expansion of (GAA)n repeats in the first intron of the FXN gene is responsible for the severe neurodegenerative disease, Friedreich's ataxia in humans. We have previously conducted an unbiased genetic screen for GAA repeat insta...
A hypomorphic allele of telomerase uncovers the minimal functional length of telomeres in Arabidopsis [0.03%]
阿拉伯芥中的一种端粒酶的低形态等位基因揭示了端粒的功能最小长度
J Matthew Watson,Johanna Trieb,Martina Troestl et al.
J Matthew Watson et al.
Despite the essential requirement of telomeric DNA for genome stability, the length of telomere tracts between species substantially differs, raising the question of the minimal length of telomeric DNA necessary for proper function. Here, w...
Interplay between extreme drift and selection intensities favors the fixation of beneficial mutations in selfing maize populations [0.03%]
极端遗传漂变和选择强度之间的相互作用有利于自交玉米群体中有利突变的固定
Arnaud Desbiez-Piat,Arnaud Le Rouzic,Maud I Tenaillon et al.
Arnaud Desbiez-Piat et al.
Population and quantitative genetic models provide useful approximations to predict long-term selection responses sustaining phenotypic shifts, and underlying multilocus adaptive dynamics. Valid across a broad range of parameters, their use...