Distinct requirements for Pho, Sfmbt, and Ino80 for cell survival in Drosophila [0.03%]
Pho、Sfmbt和Ino80在果蝇细胞生存中的不同需求
Pavel Elizarev,Katja Finkl,Jürg Müller
Pavel Elizarev
The Drosophila proteins Pleiohomeotic (Pho) and its paralog Pho-like (Phol) are the homologs of the mammalian transcription factor YY1. Pho and Phol are subunits of the Polycomb group protein complex PhoRC and they are also stably associate...
The neural crest/domestication syndrome hypothesis, explained: reply to Johnsson, Henriksen, and Wright [0.03%]
神经嵴/驯化综合征假说解释：对Johnsson，Henriksen和Wright的回复
Adam S Wilkins,Richard Wrangham,W Tecumseh Fitch
Adam S Wilkins
The Drosophila HP1 family is associated with active gene expression across chromatin contexts [0.03%]
果蝇HP1家族在染色质环境中与活性基因表达相关联
John M Schoelz,Justina X Feng,Nicole C Riddle
John M Schoelz
Drosophila Heterochromatin Protein 1a (HP1a) is essential for heterochromatin formation and is involved in transcriptional silencing. However, certain loci require HP1a to be transcribed. One model posits that HP1a acts as a transcriptional...
Loss of the Dβ1 nicotinic acetylcholine receptor subunit disrupts bursicon-driven wing expansion and diminishes adult viability in Drosophila melanogaster [0.03%]
Dβ1烟碱型乙酰胆碱受体亚基的丢失破坏了Drosophila melanogaster中bursicon驱动的翅膀扩张并降低了成虫的存活率
Danielle Christesen,Ying Ting Yang,Wei Chen et al.
Danielle Christesen et al.
Cholinergic signaling dominates the insect central nervous system, contributing to numerous fundamental pathways and behavioral circuits. However, we are only just beginning to uncover the diverse roles different cholinergic receptors may p...
Ensemble epistasis: thermodynamic origins of nonadditivity between mutations [0.03%]
集合上位性：突变间非加和性的热力学起源
Anneliese J Morrison,Daria R Wonderlick,Michael J Harms
Anneliese J Morrison
Epistasis-when mutations combine nonadditively-is a profoundly important aspect of biology. It is often difficult to understand its mechanistic origins. Here, we show that epistasis can arise from the thermodynamic ensemble, or the set of i...
The neural crest cell hypothesis: no unified explanation for domestication [0.03%]
神经嵴细胞假说：对驯化没有统一的解释
Martin Johnsson,Rie Henriksen,Dominic Wright
Martin Johnsson
Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast [0.03%]
基于进化上保守的药物作用、杀虫剂抗性突变和人源化酵母发现新的血管破坏剂
Riddhiman K Garge,Hye Ji Cha,Chanjae Lee et al.
Riddhiman K Garge et al.
Thiabendazole (TBZ) is an FDA-approved benzimidazole widely used for its antifungal and antihelminthic properties. We showed previously that TBZ is also a potent vascular disrupting agent and inhibits angiogenesis at the tissue level by dis...
A scaling law of multilevel evolution: how the balance between within- and among-collective evolution is determined [0.03%]
多级演化的缩放规律：集体内演化与集体间演化的平衡是如何确定的
Nobuto Takeuchi,Namiko Mitarai,Kunihiko Kaneko
Nobuto Takeuchi
Numerous living systems are hierarchically organized, whereby replicating components are grouped into reproducing collectives-e.g., organelles are grouped into cells, and cells are grouped into multicellular organisms. In such systems, evol...
Adam J Isabella,Eduardo Leyva-Díaz,Takuya Kaneko et al.
Adam J Isabella et al.
Bend or break: how biochemically versatile molecules enable metabolic division of labor in clonal microbial communities [0.03%]
弯曲或折断：生化多样性的分子如何使克隆微生物群落实现代谢分工
Sriram Varahan,Sunil Laxman
Sriram Varahan
In fluctuating nutrient environments, isogenic microbial cells transition into "multicellular" communities composed of phenotypically heterogeneous cells, showing functional specialization. In fungi (such as budding yeast), phenotypic heter...