Diego Ortega-Del Vecchyo,Kirk E Lohmueller,John Novembre
Diego Ortega-Del Vecchyo
Recent genome sequencing studies with large sample sizes in humans have discovered a vast quantity of low-frequency variants, providing an important source of information to analyze how selection is acting on human genetic variation. In ord...
Karen Voelkel-Meiman,Ashwini Oke,Arden Feil et al.
Karen Voelkel-Meiman et al.
A large subset of meiotic recombination intermediates form within the physical context of synaptonemal complex (SC), but the functional relationship between SC structure and homologous recombination remains obscure. Our prior analysis of st...
Marinela Dukić,Kirsten Bomblies
Marinela Dukić
The number and placement of meiotic crossover events during meiosis have important implications for the fidelity of chromosome segregation as well as patterns of inheritance. Despite the functional importance of recombination, recombination...
Powerful, efficient QTL mapping in Drosophila melanogaster using bulked phenotyping and pooled sequencing [0.03%]
利用分组表型和混合测序在黑腹果蝇中进行强大而高效的QTL定位
Stuart J Macdonald,Kristen M Cloud-Richardson,Dylan J Sims-West et al.
Stuart J Macdonald et al.
Despite the value of recombinant inbred lines for the dissection of complex traits, large panels can be difficult to maintain, distribute, and phenotype. An attractive alternative to recombinant inbred lines for many traits leverages select...
Corrigendum to: Fast Estimation of Recombination Rates Using Topological Data Analysis [0.03%]
图论数据分析的快速重组率估计的更正通知书
Devon P Humphreys,Melissa R McGuirl,Miriam Miyagi et al.
Devon P Humphreys et al.
Published Erratum
Genetics. 2022 Feb 4;220(2):iyab194. DOI:10.1093/genetics/iyab194 2022
microRNA-252 and FoxO repress inflammaging by a dual inhibitory mechanism on Dawdle-mediated TGF-β pathway in Drosophila [0.03%]
果蝇中miR-252和FoxO通过抑制Dawdle介导的TGF-β信号通路双机制抑制炎症衰老
Xiaofen Wu,Kongyan Niu,Xiaofan Wang et al.
Xiaofen Wu et al.
Inflammaging refers to low-grade, chronically activated innate immunity that has deleterious effects on healthy lifespan. However, little is known about the intrinsic signaling pathway that elicits innate immune genes during aging. Here, us...
A tandem duplication in Drosophila melanogaster shows enhanced expression beyond the gene copy number [0.03%]
果蝇串联重复序列的基因表达超二倍效应
David W Loehlin,Jeremiah Y Kim,Caleigh O Paster
David W Loehlin
Tandem duplicated genes are common features of genomes, but the phenotypic consequences of their origins are not well understood. It is not known whether a simple doubling of gene expression should be expected, or else some other expression...
FlyPhoneDB: an integrated web-based resource for cell-cell communication prediction in Drosophila [0.03%]
FlyPhoneDB：一个集成的网络资源，用于预测果蝇细胞间通讯
Yifang Liu,Joshua Shing Shun Li,Jonathan Rodiger et al.
Yifang Liu et al.
Multicellular organisms rely on cell-cell communication to exchange information necessary for developmental processes and metabolic homeostasis. Cell-cell communication pathways can be inferred from transcriptomic datasets based on ligand-r...
Barbara J Meyer
Barbara J Meyer
Abnormalities in chromosome number have the potential to disrupt the balance of gene expression and thereby decrease organismal fitness and viability. Such abnormalities occur in most solid tumors and also cause severe developmental defects...
Erratum to: Proof of principle for piggyBac-mediated transgenesis in the flatworm Macrostomum lignano [0.03%]
扁 worms中由piggyBac介导的转基因原理的证明错误说法纠正
Kirill Ustyantsev,Jakub Wudarski,Igor Sukhikh et al.
Kirill Ustyantsev et al.
Published Erratum
Genetics. 2022 Feb 4;220(2):iyab219. DOI:10.1093/genetics/iyab219 2022