Intrinsic base substitution patterns in diverse species reveal links to cancer and metabolism [0.03%]
来自不同物种的内在碱基替换模式揭示了与癌症和代谢之间的联系
Suzana P Gelova,Kassidy N Doherty,Salma Alasmar et al.
Suzana P Gelova et al.
Analyses of large-scale cancer sequencing data have revealed that mutagenic processes can create distinctive patterns of base substitutions, called mutational signatures. Interestingly, mutational patterns resembling some of these signature...
Su(var)2-10- and Su(var)205-dependent upregulation of the heterochromatic gene neverland is required for developmental transition in Drosophila [0.03%]
苏共(var)2-10和苏共(var)205依赖的异染色质基因neverland上调是果蝇发育转换所必需的
Yuya Ohhara,Yuki Kato,Takumi Kamiyama et al.
Yuya Ohhara et al.
Animals develop from juveniles to sexually mature adults through the action of steroid hormones. In insect metamorphosis, a surge of the steroid hormone ecdysone prompts the transition from the larval to the adult stage. Ecdysone is synthes...
Spalt and disco define the dorsal-ventral neuroepithelial compartments of the developing Drosophila medulla [0.03%]
Spalt和Disco定义了发育中的Drosophila medulla的背腹神经上皮区室
Priscilla Valentino,Ted Erclik
Priscilla Valentino
Spatial patterning of neural stem cell populations is a powerful mechanism by which to generate neuronal diversity. In the developing Drosophila medulla, the symmetrically dividing neuroepithelial cells of the outer proliferation center cre...
Rapid large-scale genomic introgression in Arabidopsis suecica via an autoallohexaploid bridge [0.03%]
拟南芥属进化中的快速大范围基因组引进事件及自异六倍体桥梁的作用
Vidya Oruganti,Helena Toegelová,Aleš Pečinka et al.
Vidya Oruganti et al.
Gene flow between species in the genus Arabidopsis occurs in significant amounts, but how exactly gene flow is achieved is not well understood. Polyploidization may be one avenue to explain gene flow between species. One problem, however, w...
Sharu Paul Sharma,Thomas Peterson
Sharu Paul Sharma
Eukaryotic genomes are large and complex, and gene expression can be affected by multiple regulatory elements and their positions within the dynamic chromatin architecture. Transposable elements are known to play important roles in genome e...
Archetypes of inflorescence: genome-wide association networks of panicle morphometric, growth, and disease variables in a multiparent oat population [0.03%]
基于多亲本燕麦群体的分蘖花序表型全基因组关联网络及重要位点鉴定
Craig H Carlson,Jason D Fiedler,Sepehr Mohajeri Naraghi et al.
Craig H Carlson et al.
There is limited information regarding the morphometric relationships of panicle traits in oat (Avena sativa) and their contribution to phenology and growth, physiology, and pathology traits important for yield. To model panicle growth and ...
Complex genetics cause and constrain fungal persistence in different parts of the mammalian body [0.03%]
复杂的遗传机制导致和限制了真菌在哺乳动物身体不同部位的持久性
Martin N Mullis,Caleb Ghione,Michael Lough-Stevens et al.
Martin N Mullis et al.
Determining how genetic polymorphisms enable certain fungi to persist in mammalian hosts can improve understanding of opportunistic fungal pathogenesis, a source of substantial human morbidity and mortality. We examined the genetic basis of...
3D chromatin structure in chondrocytes identifies putative osteoarthritis risk genes [0.03%]
软骨细胞中的三维染色体结构确定了潜在的骨关节炎风险基因
Eliza Thulson,Eric S Davis,Susan D&#x;Costa et al.
Eliza Thulson et al.
Genome-wide association studies have identified over 100 loci associated with osteoarthritis risk, but the majority of osteoarthritis risk variants are noncoding, making it difficult to identify the impacted genes for further study and ther...
Spatial structure alters the site frequency spectrum produced by hitchhiking [0.03%]
空间结构改变了伴连选择产生的位点频率谱
Jiseon Min,Misha Gupta,Michael M Desai et al.
Jiseon Min et al.
The reduction of genetic diversity due to genetic hitchhiking is widely used to find past selective sweeps from sequencing data, but very little is known about how spatial structure affects hitchhiking. We use mathematical modeling and simu...
Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in Caenorhabditiselegans [0.03%]
线虫通过调控嗅觉受体表达调节发育史对成年期行为偏好的影响
Travis Kyani-Rogers,Alison Philbrook,Ian G McLachlan et al.
Travis Kyani-Rogers et al.
Developmental experiences play critical roles in shaping adult physiology and behavior. We and others previously showed that adult Caenorhabditiselegans which transiently experienced dauer arrest during development (postdauer) exhibit disti...