Sevenless: its function and structure in the specification of the Drosophila R7 photoreceptor [0.03%]
七少：在指定果蝇R7视网膜感光细胞中的作用及结构
Andrew Tomlinson
Andrew Tomlinson
The fly eye is composed of hundreds of ommatidia, each containing a stereotyped pattern of photoreceptors and assorted support cells. Over the past 50 years, molecular genetic studies have illuminated how the fates of many of these cells ar...
Daniel J B Smith,Guilhem Doulcier,Pierrick Bourrat et al.
Daniel J B Smith et al.
Evolutionary "fitness" is operationalized in many different ways in models. Its role is to quantify that which is favored by natural selection. Generally, short-term ability to survive and reproduce (e.g. expected number of surviving offspr...
Jiseon Min,Yuxin Ning,Nathaniel S Pope et al.
Jiseon Min et al.
Simulation-based inference methods are increasingly being used in population genetics due to their flexibility and ability to be applied in settings where likelihood-based methods are intractable. Perhaps the best known such method is Appro...
Prevalence, distribution, and mechanisms of genetic dominance in the yeast mating pathway [0.03%]
酵母交配途径中遗传显性的流行率、分布及机制
M Grace Allen,Artemiza A Martínez,Gregory I Lang
M Grace Allen
The proportion of mutations that are dominant is a fundamental genetic parameter affecting the rate of adaptation, the efficacy of selection, and the maintenance of variation in populations. Yet, estimates for this parameter vary greatly. H...
Targeted Allele Frequency Tuning (TAFT) in breeding populations via alternative optimum contribution selection [0.03%]
通过替代最优贡献选择在育种群体中进行目标等位基因频率调节(TAFT)
Tobias A M Niehoff,Marije J Steensma,Harmen P Doekes et al.
Tobias A M Niehoff et al.
When managing the rate of genomic inbreeding using genomic relationship matrices, allele frequencies tend to be moved towards the frequencies used for centering genotypes in those matrices. Here, we explore if this behavior could be exploit...
The yeast mitochondrial Porin represses Snf1/AMP Kinase signaling to attenuate viral replication [0.03%]
酿酒酵母线粒体电压依赖性阴离子通道蛋白Porin通过抑制Snf1/AMPK信号通路来抑制病毒复制
Sabrina Chau,Serena Marek,Aayushee Khanna et al.
Sabrina Chau et al.
Although fungi are broadly infected with mycoviruses, the antiviral mechanisms fungal cells use to oppose viral replication are not well understood. Here we discover a new mitochondrially controlled signaling mechanism in the budding yeast ...
Bruce S Weir,Jérôme Goudet
Bruce S Weir
We offer our perspective on the rich literature on the estimation of measures of inbreeding, relatedness, and population structure, beginning with Sewall Wright's F-statistics and moving onto the descriptive statistics of Masatoshi Nei and ...
Amino acid exchangeability and surface accessibility underpin the effects of single substitutions [0.03%]
单个氨基酸替换效应的理论基础：氨基酸交换性和表面可及性的影响
Berk A Alpay,Piyush Nanda,Emma Nagy et al.
Berk A Alpay et al.
Deep mutational scans have measured the effects of many mutations on a large variety of proteins. We use a collection of these scans to perform a meta-analysis of the effects of single amino acid substitutions, modeling the relative deleter...
Dmitry Grinevich,Oliver Kompathoum,Jingbaoyi Li et al.
Dmitry Grinevich et al.
Paracoccidioides is a genus of dimorphic fungal pathogens endemic to Latin America. We generated long-read de novo assemblies for 11 isolates representing four species of the brasiliensis complex (P. brasiliensis, P. americana, P. restrepie...
Leveraging long-read assemblies and machine learning to enhance short-read transposable element detection and genotyping [0.03%]
利用长读组装和机器学习增强短读转座元件检测和基因分型
Austin Daigle,Logan S Whitehouse,Roy Zhao et al.
Austin Daigle et al.
Transposable elements (TEs) are parasitic genomic elements that are ubiquitous across the tree of life and play a crucial role in genome evolution. Advances in long-read sequencing have allowed highly accurate TE detection, though at a high...