Causes of variability in estimates of mutational variance from mutation accumulation experiments [0.03%]
突变积累实验中估计的突变变异系数的变化原因
Cara Conradsen,Mark W Blows,Katrina McGuigan
Cara Conradsen
Characteristics of the new phenotypic variation introduced via mutation have broad implications in evolutionary and medical genetics. Standardized estimates of this mutational variance, VM, span 2 orders of magnitude, but the causes of this...
Overdominant and partially dominant mutations drive clonal adaptation in diploid Saccharomyces cerevisiae [0.03%]
优势突变驱动二倍体Saccharomyces cerevisiae的克隆适应性进化
Dimitra Aggeli,Daniel A Marad,Xianan Liu et al.
Dimitra Aggeli et al.
Identification of adaptive targets in experimental evolution typically relies on extensive replication and genetic reconstruction. An alternative approach is to directly assay all mutations in an evolved clone by generating pools of segrega...
Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in Drosophila melanogaster [0.03%]
果蝇Set8/KMT5A和组蛋白H4赖氨酸20突变产生不同的发育表型
Aaron T Crain,Stephen Klusza,Robin L Armstrong et al.
Aaron T Crain et al.
Mono-methylation of histone H4 lysine 20 (H4K20me1) is catalyzed by Set8/KMT5A and regulates numerous aspects of genome organization and function. Loss-of-function mutations in Drosophila melanogaster Set8 or mammalian KMT5A prevent H4K20me...
Cas9-mediated maternal effect and derived resistance alleles in a gene-drive strain of the African malaria vector mosquito, Anopheles gambiae [0.03%]
《基于CRISPR-Cas9的母体效应和冈比亚疟蚊基因驱动品系中衍生抗性等位基因的研究》
Rebeca Carballar-Lejarazú,Taylor Tushar,Thai Binh Pham et al.
Rebeca Carballar-Lejarazú et al.
CRISPR/Cas9 technologies are important tools for the development of gene-drive systems to modify mosquito vector populations to control the transmission of pathogens that cause diseases such as malaria. However, one of the challenges for cu...
Population genetics of polymorphism and divergence in rapidly evolving populations [0.03%]
快速演化群体的多态性与分化群体遗传学
Matthew J Melissa,Benjamin H Good,Daniel S Fisher et al.
Matthew J Melissa et al.
In rapidly evolving populations, numerous beneficial and deleterious mutations can arise and segregate within a population at the same time. In this regime, evolutionary dynamics cannot be analyzed using traditional population genetic appro...
Ancestry adjustment improves genome-wide estimates of regional intolerance [0.03%]
祖先调整改善了全基因组估算地区的容忍度
Tristan J Hayeck,Nicholas Stong,Evan Baugh et al.
Tristan J Hayeck et al.
Genomic regions subject to purifying selection are more likely to carry disease-causing mutations than regions not under selection. Cross species conservation is often used to identify such regions but with limited resolution to detect sele...
Rectifying nematode names [0.03%]
纠正线虫的学名
Jonathan Hodgkin
Jonathan Hodgkin
Over the past 50 years, the nematode worm Caenorhabditis elegans has become established as one of the most powerful and widely used model organisms. This article explores the origins and subsequent history of a generally accepted system for...
Valerie Wood,Paul W Sternberg,Howard D Lipshitz
Valerie Wood
Valerie Wood,Paul W Sternberg,Howard D Lipshitz
Valerie Wood
Alliance of Genome Resources Consortium
Alliance of Genome Resources Consortium
The Alliance of Genome Resources (the Alliance) is a combined effort of 7 knowledgebase projects: Saccharomyces Genome Database, WormBase, FlyBase, Mouse Genome Database, the Zebrafish Information Network, Rat Genome Database, and the Gene ...