The impact of genetic modifiers on variation in germline mutation rates within and among human populations [0.03%]
基因调节因子对人类种群和个体中生殖系突变率变异的影响
William R Milligan,Guy Amster,Guy Sella
William R Milligan
Mutation rates and spectra differ among human populations. Here, we examine whether this variation could be explained by evolution at mutation modifiers. To this end, we consider genetic modifier sites at which mutations, "mutator alleles,"...
Production of nascent ribosome precursors within the nucleolar microenvironment of Saccharomyces cerevisiae [0.03%]
酿酒酵母核仁微环境中新生核糖体前体的生成
Samantha Lin,Suchita Rajan,Sofia Lemberg et al.
Samantha Lin et al.
35S rRNA transcripts include a 5'-external transcribed spacer followed by rRNAs of the small and large ribosomal subunits. Their processing yields massive precursors that include dozens of assembly factor proteins. In Saccharomyces cerevisi...
Genetic regulation of central synapse formation and organization in Drosophila melanogaster [0.03%]
果蝇中枢突触形成的遗传调控
Juan Carlos Duhart,Timothy J Mosca
Juan Carlos Duhart
A goal of modern neuroscience involves understanding how connections in the brain form and function. Such a knowledge is essential to inform how defects in the exquisite complexity of nervous system growth influence neurological disease. St...
Modifying mosquitoes to suppress disease transmission: Is the long wait over? [0.03%]
改良蚊子以抑制疾病传播：漫长的等待终于结束了吗？
Jeffrey R Powell
Jeffrey R Powell
For more than 50 years it has been a dream of medical entomologists and public health workers to control diseases like malaria and dengue fever by modifying, through genetics and other methods, the arthropods that transmit them to humans. A...
Effects of fine-scale population structure on the distribution of heterozygosity in a long-term study of Antirrhinum majus [0.03%]
基于多年开花植物朱顶红（Antirrhinum majus）的研究，细小的种群结构对杂合度分布的影响
Parvathy Surendranadh,Louise Arathoon,Carina A Baskett et al.
Parvathy Surendranadh et al.
Many studies have quantified the distribution of heterozygosity and relatedness in natural populations, but few have examined the demographic processes driving these patterns. In this study, we take a novel approach by studying how populati...
Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization [0.03%]
乙酰辅酶a羧化酶1活性的精细调节：功能基因组学揭示赖氨酸乙酰转移酶NuA4和鞘脂代谢在调控Acc1活性和定位中的作用
Trang Pham,Elizabeth Walden,Sylvain Huard et al.
Trang Pham et al.
Acetyl-CoA Carboxylase 1 catalyzes the conversion of acetyl-CoA to malonyl-CoA, the committed step of de novo fatty acid synthesis. As a master regulator of lipid synthesis, acetyl-CoA carboxylase 1 has been proposed to be a therapeutic tar...
Defining characteristics and conservation of poorly annotated genes in Caenorhabditis elegans using WormCat 2.0 [0.03%]
利用WormCat 2.0定义基因的特征并保存线虫（钙视网膜蛋白秀丽隐杆线虫）中注释较少的基因
Daniel P Higgins,Caroline M Weisman,Dominique S Lui et al.
Daniel P Higgins et al.
Omics tools provide broad datasets for biological discovery. However, the computational tools for identifying important genes or pathways in RNA-seq, proteomics, or GWAS (Genome-Wide Association Study) data depend on Gene Ontogeny annotatio...
Serotonin signals through postsynaptic Gαq, Trio RhoGEF, and diacylglycerol to promote Caenorhabditis elegans egg-laying circuit activity and behavior [0.03%]
五羟色胺通过果蝇卵细胞排除回路中的后突触Gαq，TrioRhoGEF和甘油二酯通路促进线虫产卵电路活性及行为反应
Pravat Dhakal,Sana I Chaudhry,Rossana Signorelli et al.
Pravat Dhakal et al.
Activated Gαq signals through phospholipase-Cβ and Trio, a Rho GTPase exchange factor (RhoGEF), but how these distinct effector pathways promote cellular responses to neurotransmitters like serotonin remains poorly understood. We used the...
Variation in leaf transcriptome responses to elevated ozone corresponds with physiological sensitivity to ozone across maize inbred lines [0.03%]
玉米自交系叶片转录组对臭氧升高的响应变化与其生理敏感性一致
Adalena V Nanni,Alison M Morse,Jeremy R B Newman et al.
Adalena V Nanni et al.
We examine the impact of sustained elevated ozone concentration on the leaf transcriptome of 5 diverse maize inbred genotypes, which vary in physiological sensitivity to ozone (B73, Mo17, Hp301, C123, and NC338), using long reads to assembl...
LKB1 is physiologically required for sleep from Drosophila melanogaster to the Mus musculus [0.03%]
从果蝇到小鼠，LKB1是睡眠的生理需求因素
Ziyi Liu,Lifen Jiang,Chaoyi Li et al.
Ziyi Liu et al.
Liver Kinase B1 (LKB1) is known as a master kinase for 14 kinases related to the adenosine monophosphate-activated protein kinase. Two of them salt inducible kinase 3 and adenosine monophosphate-activated protein kinase α have previously b...