Imp and Syp mediated temporal patterning of neural stem cells in the developing Drosophila CNS [0.03%]
发育中的Drosophila中枢神经系统的Imp和Syp介导的神经干细胞的时间模式化
Ishrat Maliha Islam,Ted Erclik
Ishrat Maliha Islam
The assembly of complex neural circuits requires that stem cells generate diverse types of neurons in the correct temporal order. Pioneering work in the Drosophila embryonic ventral nerve cord has shown that neural stem cells are temporally...
Turning coldspots into hotspots: targeted recruitment of axis protein Hop1 stimulates meiotic recombination in Saccharomyces cerevisiae [0.03%]
由冷点变热点：轴丝蛋白Hop1的靶向募集可促进模式真核生物酿酒酵母中的交换型重组
Anura Shodhan,Martin Xaver,David Wheeler et al.
Anura Shodhan et al.
The DNA double-strand breaks that initiate meiotic recombination are formed in the context of the meiotic chromosome axis, which in Saccharomyces cerevisiae contains a meiosis-specific cohesin isoform and the meiosis-specific proteins Hop1 ...
A distinct P-body-like granule is induced in response to the disruption of microtubule integrity in Saccharomyces cerevisiae [0.03%]
破坏微管结构可诱发明显的P体类似颗粒形成——以酿酒酵母为例研究非经典P体的形成机制
Zachary Hurst,Wenfang Liu,Qian Shi et al.
Zachary Hurst et al.
The Processing-body is a conserved membraneless organelle that has been implicated in the storage and/or decay of mRNAs. Although Processing-bodies have been shown to be induced by a variety of conditions, the mechanisms controlling their a...
A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability [0.03%]
酿酒酵母Rtt109组蛋白乙酰转移酶在R环稳态及相关的基因组不稳定性中的作用
Juan Carlos Cañas,María Luisa García-Rubio,Alicia García et al.
Juan Carlos Cañas et al.
The stability of the genome is occasionally challenged by the formation of DNA-RNA hybrids and R-loops, which can be influenced by the chromatin context. This is mainly due to the fact that DNA-RNA hybrids hamper the progression of replicat...
Octopaminergic/tyraminergic Tdc2 neurons regulate biased sperm usage in female Drosophila melanogaster [0.03%]
Tdc2神经元通过八胺/酪氨调节雄性小鼠偏好使用生殖细胞中的精子
Dawn S Chen,Andrew G Clark,Mariana F Wolfner
Dawn S Chen
In polyandrous internally fertilizing species, a multiply-mated female can use stored sperm from different males in a biased manner to fertilize her eggs. The female's ability to assess sperm quality and compatibility is essential for her r...
Hox genes collaborate with helix-loop-helix factor Grainyhead to promote neuroblast apoptosis along the anterior-posterior axis of the Drosophila larval central nervous system [0.03%]
咽侧体Hox基因和Grainyhead蛋白共同促进果蝇幼虫中枢神经系统沿头尾轴的神经前体细胞凋亡
Rashmi Sipani,Rohit Joshi
Rashmi Sipani
Hox genes code for a family of a homeodomain containing transcription factors that use TALE-HD containing factors Pbx/Exd and Meis/Homothorax to specify the development of the anterior-posterior axis of an organism. However, the absence of ...
The Caenorhabditis elegans ASPP homolog APE-1 is a junctional protein phosphatase 1 modulator [0.03%]
一种Caenorhabditis elegans ASPP同源物APE-1是衔接蛋白磷酸酶1的调节因子
Gwendolyn M Beacham,Derek T Wei,Erika Beyrent et al.
Gwendolyn M Beacham et al.
How serine/threonine phosphatases are spatially and temporally tuned by regulatory subunits is a fundamental question in cell biology. Ankyrin repeat, SH3 domain, proline-rich-region-containing proteins are protein phosphatase 1 catalytic s...
Estimating the rates of crossover and gene conversion from individual genomes [0.03%]
从个体基因组估计交叉和基因转换的速率
Derek Setter,Sam Ebdon,Ben Jackson et al.
Derek Setter et al.
Recombination can occur either as a result of crossover or gene conversion events. Population genetic methods for inferring the rate of recombination from patterns of linkage disequilibrium generally assume a simple model of recombination t...
Visualizing and quantifying molecular and cellular processes in Caenorhabditis elegans using light microscopy [0.03%]
采用光学显微镜在秀丽隐杆线虫中可视化及量化分子和细胞过程
Pavak Shah,Zhirong Bao,Ronen Zaidel-Bar
Pavak Shah
Light microscopes are the cell and developmental biologists' "best friend," providing a means to see structures and follow dynamics from the protein to the organism level. A huge advantage of Caenorhabditis elegans as a model organism is it...
The RNA-binding protein Swm is critical for Drosophila melanogaster intestinal progenitor cell maintenance [0.03%]
RNA结合蛋白Swm对于黑腹果蝇肠道干细胞的维持至关重要
Ishara S Ariyapala,Kasun Buddika,Heather A Hundley et al.
Ishara S Ariyapala et al.
The regulation of stem cell survival, self-renewal, and differentiation is critical for the maintenance of tissue homeostasis. Although the involvement of signaling pathways and transcriptional control mechanisms in stem cell regulation hav...