A reciprocal translocation involving Aspergillus nidulans snxAHrb1/Gbp2 and gyfA uncovers a new regulator of the G2-M transition and reveals a role in transcriptional repression for the setBSet2 histone H3-lysine-36 methyltransferase [0.03%]
牵涉曲霉snxahrb1/gbp2和gyfa的互惠易位揭示了G2-M转换的新调节因子，并且发现setbset2组蛋白H3-赖氨酸36甲基转移酶在转录抑制中的作用
Steven W James,Jonathan Palmer,Nancy P Keller et al.
Steven W James et al.
Aspergillus nidulans snxA, an ortholog of Saccharomyces cerevisiae Hrb1/Gbp2 messenger RNA shuttle proteins, is-in contrast to budding yeast-involved in cell cycle regulation, in which snxA1 and snxA2 mutations as well as a snxA deletion sp...
Dcifer: an IBD-based method to calculate genetic distance between polyclonal infections [0.03%]
基于IBD的方法计算多克隆感染之间遗传距离的DCIFER方法
Inna Gerlovina,Boris Gerlovin,Isabel Rodríguez-Barraquer et al.
Inna Gerlovina et al.
An essential step toward reconstructing pathogen transmission and answering epidemiologically relevant questions from genomic data is obtaining pairwise genetic distance between infections. For recombining organisms such as malaria parasite...
Heterogeneity in viral populations increases the rate of deleterious mutation accumulation [0.03%]
病毒种群异质性增加有害突变的积累速率
Brent Allman,Katia Koelle,Daniel Weissman
Brent Allman
RNA viruses have high mutation rates, with the majority of mutations being deleterious. We examine patterns of deleterious mutation accumulation over multiple rounds of viral replication, with a focus on how cellular coinfection and heterog...
ZW sex-chromosome evolution and contagious parthenogenesis in Artemia brine shrimp [0.03%]
介形类卤虫中的ZW性染色体进化和传染性孤雌生殖
Marwan Elkrewi,Uladzislava Khauratovich,Melissa A Toups et al.
Marwan Elkrewi et al.
Eurasian brine shrimp (genus Artemia) have closely related sexual and asexual lineages of parthenogenetic females, which produce rare males at low frequencies. Although they are known to have ZW chromosomes, these are not well characterized...
Suppressor mutations that make the essential transcription factor Spn1/Iws1 dispensable in Saccharomyces cerevisiae [0.03%]
使酿酒酵母中的必需转录因子Spn1/Iws1变得无足轻重的抑制子突变
Francheska López-Rivera,James Chuang,Dan Spatt et al.
Francheska López-Rivera et al.
Spn1/Iws1 is an essential eukaryotic transcription elongation factor that is conserved from yeast to humans as an integral member of the RNA polymerase II elongation complex. Several studies have shown that Spn1 functions as a histone chape...
Maintenance of quantitative genetic variance in complex, multitrait phenotypes: the contribution of rare, large effect variants in 2 Drosophila species [0.03%]
复杂多性状表型的数量遗传变异的维持：两个果蝇物种中稀有大型效应变异的贡献
Emma Hine,Daniel E Runcie,Scott L Allen et al.
Emma Hine et al.
The interaction of evolutionary processes to determine quantitative genetic variation has implications for contemporary and future phenotypic evolution, as well as for our ability to detect causal genetic variants. While theoretical studies...
Fixation dynamics of beneficial alleles in prokaryotic polyploid chromosomes and plasmids [0.03%]
益生等位基因在原核生物多倍体染色体和质粒中的固定动力学
Mario Santer,Anne Kupczok,Tal Dagan et al.
Mario Santer et al.
Theoretical population genetics has been mostly developed for sexually reproducing diploid and for monoploid (haploid) organisms, focusing on eukaryotes. The evolution of bacteria and archaea is often studied by models for the allele dynami...
Variation in cytonuclear expression accommodation among allopolyploid plants [0.03%]
异源多倍体植物细胞核与细胞质表达的可兼容性差异
Corrinne E Grover,Evan S Forsythe,Joel Sharbrough et al.
Corrinne E Grover et al.
Cytonuclear coevolution is a common feature among plants, which coordinates gene expression and protein products between the nucleus and organelles. Consequently, lineage-specific differences may result in incompatibilities between the nucl...
TOP-2 is differentially required for the proper maintenance of the cohesin subunit REC-8 on meiotic chromosomes in Caenorhabditis elegans spermatogenesis and oogenesis [0.03%]
TOP-2在秀丽杆线虫精子发生和卵细胞发生过程中不同地调控同源染色体配对及联会复合体中粘连蛋白REC-8的稳定维护功能
Christine Rourke,Aimee Jaramillo-Lambert
Christine Rourke
During meiotic prophase I, accurate segregation of homologous chromosomes requires the establishment of chromosomes with a meiosis-specific architecture. The sister chromatid cohesin complex and the enzyme Topoisomerase II (TOP-2) are impor...
Cytological heterogeneity of heterochromatin among 10 sequenced Drosophila species [0.03%]
十个基因组测序的类果蝇异染色质的细胞学异质性分析
Marcella Marchetti,Lucia Piacentini,Maria Francesca Berloco et al.
Marcella Marchetti et al.
In Drosophila chromosomal rearrangements can be maintained and are associated with karyotypic variability among populations from different geographic localities. The abundance of variability in gene arrangements among chromosomal arms is ev...