Intrinsically disordered arginine-glycine (RG) repeat domains tune sub-nucleolar compartmentalization in C. elegans [0.03%]
内在无序的精氨酸-甘氨酸重复区域能调节线虫核仁亚隔室化现象
Emily L Spaulding,Dustin L Updike
Emily L Spaulding
Intrinsically disordered arginine-glycine (RG) repeat domains are enriched in multilayered biomolecular condensates such as the nucleolus. C. elegans nucleolar RG repeats are dispensable for nucleolar accumulation and instead contribute to ...
Analysis of rad-51 separation of function allele suggests divergence of the SDSA and dHJ pathways prior to RAD-51 filament disassembly [0.03%]
RAD-51分离功能等位基因的分析表明SDSA和dHJ途径在RAD-51丝状解体之前发生分化
Joseph Oberlitner,Maggie Tinman,Aasthika Das et al.
Joseph Oberlitner et al.
DNA double-strand breaks (DSBs) are formed in meiosis, so their repair in the homologous recombination (HR) pathway will lead to crossover formation, which is essential for successful chromosomes segregation. HR contains two sub pathways: s...
Estimation of heritabilities and genetic correlations by time slices using predictivity in large genomic models [0.03%]
基于预测性的大型基因组模型的时窗估计育种值遗传参数
Ignacy Misztal,Gopal Gowane
Ignacy Misztal
Under genomic selection, genetic parameters may change rapidly from generation to generation. Unless genetic parameters used for a selection index are current, the expected genetic gain may be unrealistic, possibly with a decline for antago...
Identification of regions required for allelic specificity at the cell wall remodeling allorecognition checkpoint in Neurospora crassa [0.03%]
棒囊霉细胞壁重塑异亲识别检点的等位基因特异性鉴定
Adriana M Rico-Ramirez,N Louise Glass
Adriana M Rico-Ramirez
Allorecognition is the ability of organisms/cells to differentiate self from non-self. In Neurospora crassa, allorecognition systems serve as checkpoints to restrict germling/hyphal fusion between genetically incompatible strains. The cell ...
Conserved components of the macroautophagy machinery in Caenorhabditis elegans [0.03%]
秀丽隐杆线虫巨自噬作用机械的保守成分
Hong Zhang,Alicia Meléndez
Hong Zhang
Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane autophagosome and its subsequent delivery to lysosomes for degradation and recycling. In Caenorhabditis elegans, autophagy participates in diverse proces...
Ruoyu Chen,Sherilyn Grill,Benjamin Lin et al.
Ruoyu Chen et al.
The continuity of a species depends on germ cells. Germ cells are different from all the other cell types of the body (somatic cells) as they are solely destined to develop into gametes (sperm or egg) to create the next generation. In this ...
Replacement of Arabidopsis H2A.Z with human H2A.Z orthologs reveals extensive functional conservation and limited importance of the N-terminal tail sequence for Arabidopsis development [0.03%]
拟南芥H2A.Z被人类同源蛋白替代表明功能的保守性及组蛋白N端序列对于植物生长发育的有限的重要性
Paja Sijacic,Dylan H Holder,Brianna D Silver et al.
Paja Sijacic et al.
The incorporation of histone variants, distinct paralogs of core histones, into chromatin affects all DNA-templated processes in the cell, including the regulation of transcription. In recent years, much research has been focused on H2A.Z, ...
Causal network inference of cis- and trans-gene regulation of expression quantitative trait loci across human tissues [0.03%]
人类组织中表达量性状位点的顺式和反式基因调控的因果网络推理
Jarred Kvamme,Md Bahadur Badsha,Evan A Martin et al.
Jarred Kvamme et al.
Expression quantitative trait loci (eQTLs) have been identified for most genes in the human genome across tissues and cell types. While most of the eQTLs are near (i.e., cis) the associated genes on the linear genome, some can be far away o...
A new set of mutations in the second transmembrane helix of the Cox2p-W56R substantially improves its allotopic expression in Saccharomyces cerevisiae [0.03%]
线粒体Cox2p-W56R第二跨膜区的新突变簇大大提高了其在酿酒酵母中的异位表达水平
Kewin Gombeau,Stefan A Hoffmann,Yizhi Cai
Kewin Gombeau
The dual genetic control of mitochondrial respiratory function, combined with the high mutation rate of the mitochondrial genome (mtDNA), makes mitochondrial diseases among the most frequent genetic diseases in humans (1 in 5,000 in adults)...
Heat Tolerance and Genetic Adaptations in Caenorhabditis briggsae: Insights from Comparative Studies with C. elegans [0.03%]
解码秀丽隐杆线虫高温耐受及遗传适应的机制：与巴氏线虫的比较研究
Nikita Jhaveri,Harvir Bhullar,Paul W Sternberg et al.
Nikita Jhaveri et al.
Temperature tolerance varies widely across species and plays a crucial role in shaping physiological and evolutionary adaptations. Here, we investigate thermal stress responses in Caenorhabditis briggsae and C. elegans using multiple isolat...