An efficient exact algorithm for identifying hybrids using population genomic sequences [0.03%]
一种使用群体基因组序列识别杂种的有效精确算法
Sneha Chakraborty,Bruce Rannala
Sneha Chakraborty
The identification of individuals that have a recent hybrid ancestry (between populations or species) has been a goal of naturalists for centuries. Since the 1960s, codominant genetic markers have been used with statistical and computationa...
The racist origins, racialist connotations, and purity assumptions of the concept of "admixture" in human evolutionary genetics [0.03%]
人类进化遗传学中“杂交”概念的种族主义起源、种族主义内涵及纯洁性假设
Kostas Kampourakis,Erik L Peterson
Kostas Kampourakis
The concept of admixture is currently widely being used, both in population genetics research and in DNA ancestry testing discourse. It is assumed to describe the process of gene flow between 2 previously distinct populations that eventuall...
Hotspot of de novo telomere addition stabilizes linear amplicons in yeast grown in sulfate-limiting conditions [0.03%]
酵母在硫酸盐限制条件下培养时，新生端粒添加热点可稳定线性扩增子
Remington E Hoerr,Alex Eng,Celia Payen et al.
Remington E Hoerr et al.
Evolution is driven by the accumulation of competing mutations that influence survival. A broad form of genetic variation is the amplification or deletion of DNA (≥50 bp) referred to as copy number variation (CNV). In humans, CNV may be in...
Lissencephaly-1 mutations enhance traumatic brain injury outcomes in Drosophila [0.03%]
无脑回小脑畸形-1突变增强果蝇创伤性脑损伤的结果
Rebeccah J Katzenberger,Barry Ganetzky,David A Wassarman
Rebeccah J Katzenberger
Traumatic brain injury (TBI) outcomes vary greatly among individuals, but most of the variation remains unexplained. Using a Drosophila melanogaster TBI model and 178 genetically diverse lines from the Drosophila Genetic Reference Panel (DG...
Dynamic coalescence of yeast Heat Shock Protein genes bypasses the requirement for actin [0.03%]
酵母热休克蛋白基因的动态共聚旁路了对肌动蛋白的需求
Linda S Rubio,David S Gross
Linda S Rubio
Nuclear actin has been implicated in dynamic chromatin rearrangements in diverse eukaryotes. In mammalian cells, it is required to reposition double-strand DNA breaks to enable homologous recombination repair and to enhance transcription by...
SPR-1/CoREST facilitates the maternal epigenetic reprogramming of the histone demethylase SPR-5/LSD1 [0.03%]
SPR-1/CoREST促进组蛋白去甲基化酶SPR-5/LSD1的母体表观遗传重编程
Brandon S Carpenter,Alyssa Scott,Robert Goldin et al.
Brandon S Carpenter et al.
Maternal reprogramming of histone methylation is critical for reestablishing totipotency in the zygote, but how histone-modifying enzymes are regulated during maternal reprogramming is not well characterized. To address this gap, we asked w...
A modERN resource: identification of Drosophila transcription factor candidate target genes using RNAi [0.03%]
一个现代资源：使用RNAi鉴定果蝇转录因子候选靶基因
William W Fisher,Ann S Hammonds,Richard Weiszmann et al.
William W Fisher et al.
Transcription factors (TFs) play a key role in development and in cellular responses to the environment by activating or repressing the transcription of target genes in precise spatial and temporal patterns. In order to develop a catalog of...
Drosophila postembryonic nervous system development: a model for the endocrine control of development [0.03%]
果蝇的后胚胎神经系统的发育：一个内分泌控制发育的模型系统
James W Truman,Lynn M Riddiford
James W Truman
During postembryonic life, hormones, including ecdysteroids, juvenile hormones, insulin-like peptides, and activin/TGFβ ligands act to transform the larval nervous system into an adult version, which is a fine-grained mosaic of recycled la...
Kota Mizumoto,Yishi Jin,Jean-Louis Bessereau
Kota Mizumoto
The nematode Caenorhabditis elegans is a research model organism particularly suited to the mechanistic understanding of synapse genesis in the nervous system. Armed with powerful genetics, knowledge of complete connectomics, and modern gen...