2022 updates to the Rat Genome Database: a Findable, Accessible, Interoperable, and Reusable (FAIR) resource [0.03%]
2022年实验鼠基因组数据库更新：一个可查找、可访问、可互操作、可重用的（FAIR）资源
Mahima Vedi,Jennifer R Smith,G Thomas Hayman et al.
Mahima Vedi et al.
The Rat Genome Database (RGD, https://rgd.mcw.edu) has evolved from simply a resource for rat genetic markers, maps, and genes, by adding multiple genomic data types and extensive disease and phenotype annotations and developing tools to ef...
Long noncoding RNA CR46040 is essential for injury-stimulated regeneration of intestinal stem cells in Drosophila [0.03%]
果蝇肠干细胞损伤诱导再生的关键调控长非编码RNA CR46040
Qi Xu,Jun Liu,Xiao Du et al.
Qi Xu et al.
Long noncoding RNAs (lncRNAs) play important regulatory roles in stem cell self-renewal, pluripotency maintenance, and differentiation. Till now, there is very limited knowledge about how lncRNAs regulate intestinal stem cells (ISCs), and l...
Substantial rDNA copy number reductions alter timing of development and produce variable tissue-specific phenotypes in C. elegans [0.03%]
rDNA拷贝数的大量减少会改变线虫发育的时间并产生可变的组织特异性表型
Elizabeth A Morton,Ashley N Hall,Josh T Cuperus et al.
Elizabeth A Morton et al.
The genes that encode ribosomal RNAs are present in several hundred copies in most eukaryotes. These vast arrays of repetitive ribosomal DNA (rDNA) have been implicated not just in ribosome biogenesis, but also aging, cancer, genome stabili...
Hybrid inferiority and genetic incompatibilities drive divergence of fungal pathogens infecting the same host [0.03%]
杂交劣势和遗传不兼容性驱动感染相同宿主的真菌病原体分化
Jennifer D Yuzon,Nathan A Wyatt,Asieh Vasighzadeh et al.
Jennifer D Yuzon et al.
Agro-ecosystems provide environments that are conducive for rapid evolution and dispersal of plant pathogens. Previous studies have demonstrated that hybridization of crop pathogens can give rise to new lineages with altered virulence profi...
Distinct Wolbachia localization patterns in oocytes of diverse host species reveal multiple strategies of maternal transmission [0.03%]
疣皮螨卵细胞中沃尔巴克体不同的定位模式揭示了其母系传递的多种策略
Yonah A Radousky,Michael T J Hague,Sommer Fowler et al.
Yonah A Radousky et al.
A broad array of endosymbionts radiate through host populations via vertical transmission, yet much remains unknown concerning the cellular basis, diversity, and routes underlying this transmission strategy. Here, we address these issues, b...
Qian Zhang,Yang Zhang,Qi Zhang et al.
Qian Zhang et al.
Adult stem cells maintain homeostatic self-renewal through the strategy of either population or single-cell asymmetry, and the former type of stem cells are thought to take passive while the latter ones take active competition for niche occ...
Selection and geography shape male reproductive tract transcriptomes in Drosophila melanogaster [0.03%]
龙伯格果蝇生殖道转录组受选择与地理因素的影响
Julie M Cridland,Colin E Contino,David J Begun
Julie M Cridland
Transcriptome analysis of several animal clades suggests that male reproductive tract gene expression evolves quickly. However, the factors influencing the abundance and distribution of within-species variation, the ultimate source of inter...
Gene Ontology Consortium;Suzi A Aleksander,James Balhoff,Seth Carbon et al.
Gene Ontology Consortium;Suzi A Aleksander et al.
The Gene Ontology (GO) knowledgebase (http://geneontology.org) is a comprehensive resource concerning the functions of genes and gene products (proteins and noncoding RNAs). GO annotations cover genes from organisms across the tree of life ...
From multiallele fish to nonstandard environments, how ZFIN assigns phenotypes, human disease models, and gene expression annotations to genes [0.03%]
从多态性鱼到非标准环境，ZFIN如何对基因分配表型、人类疾病模型和基因表达注释
Yvonne M Bradford,Ceri E Van Slyke,Douglas G Howe et al.
Yvonne M Bradford et al.
Danio rerio is a model organism used to investigate vertebrate development. Manipulation of the zebrafish genome and resultant gene products by mutation or targeted knockdown has made the zebrafish a good system for investigating gene funct...
Genetic association models are robust to common population kinship estimation biases [0.03%]
基因关联模型对普通人群体亲缘关系估计偏差具有鲁棒性
Zhuoran Hou,Alejandro Ochoa
Zhuoran Hou
Common genetic association models for structured populations, including principal component analysis (PCA) and linear mixed-effects models (LMMs), model the correlation structure between individuals using population kinship matrices, also k...