Regulation of the hypertonic stress response by the 3' mRNA cleavage and polyadenylation complex [0.03%]
调控高渗应激反应的3′mRNA切割和多聚腺苷酸化复合物的作用机制研究
Sarel J Urso,Anson Sathaseevan,W Brent Derry et al.
Sarel J Urso et al.
Maintenance of osmotic homeostasis is one of the most aggressively defended homeostatic set points in physiology. One major mechanism of osmotic homeostasis involves the upregulation of proteins that catalyze the accumulation of solutes cal...
John Wakeley,Wai-Tong Louis Fan,Evan Koch et al.
John Wakeley et al.
Recurrent mutation produces multiple copies of the same allele which may be co-segregating in a population. Yet, most analyses of allele-frequency or site-frequency spectra assume that all observed copies of an allele trace back to a single...
Complexities of recapitulating polygenic effects in natural populations: replication of genetic effects on wing shape in artificially selected and wild-caught populations of Drosophila melanogaster [0.03%]
果蝇复盘多基因效应的复杂性：在人工选择和野生采集群体中复制遗传效应以研究翅膀形状的影响
Katie Pelletier,William R Pitchers,Anna Mammel et al.
Katie Pelletier et al.
Identifying the genetic architecture of complex traits is important to many geneticists, including those interested in human disease, plant and animal breeding, and evolutionary genetics. Advances in sequencing technology and statistical me...
Loss- and gain-of-function analyses reveal the essential role of Cyp19a1 in ovarian determination of the red-eared slider turtle [0.03%]
-loss-和gain-功能分析揭示了Cyp19a1基因在红耳滑龟卵巢决定中的重要作用
Jiadong Shen,Wei Sun,Kaiyue Wu et al.
Jiadong Shen et al.
Estrogen signaling exerts a decisive role in female sex determination and differentiation in chicken and fish. Aromatase encoded by Cyp19a1 is the key enzyme that catalyzes the conversion of androgen to estrogen. Correlative analyses implic...
Distinct clusters of human pain gene orthologs in Caenorhabditis elegans regulate thermo-nociceptive sensitivity and plasticity [0.03%]
人类疼痛基因同源物在秀丽隐杆线虫中的 distinct 簇调控热痛敏感性和可塑性
Aurore Jordan,Dominique A Glauser
Aurore Jordan
The detection and avoidance of harmful stimuli are essential animal capabilities. The molecular and cellular mechanisms controlling nociception and its plasticity are conserved, genetically controlled processes of broad biomedical interest ...
Vasily V Ptushenko,Evgeny V Ramensky
Vasily V Ptushenko
Nikolai K. Koltzoff (Koltsov) (1872-1940) is one of the key figures in Russian biology. He essentially initiated Russian physicochemical biology and established a large scientific school in the area. Among his disciples, there are the genet...
Peter J van Dijk,T H Noel Ellis
Peter J van Dijk
According to the revisionist interpretation of Mendel's pea crosses, his primary aim was not to study the inheritance of traits. Instead, he was interested in the question raised by Linnaeus as to whether new species could arise from the hy...
An unknown essential function of tRNA splicing endonuclease is linked to the integrated stress response and intron debranching [0.03%]
tRNA内含子切除内切核酸酶未知的必要功能与整合应激反应及内含子去分支相连系
Jennifer E Hurtig,Ambro van Hoof
Jennifer E Hurtig
tRNA splicing endonuclease (TSEN) has a well-characterized role in transfer RNA (tRNA) splicing but also other functions. For yeast TSEN, these other functions include degradation of a subset of mRNAs that encode mitochondrial proteins and ...
The trouble with triples: Examining the impact of measurement error in mediation analysis [0.03%]
中介分析中测量误差的影响：三元关系的麻烦
Madeleine S Gastonguay,Gregory R Keele,Gary A Churchill
Madeleine S Gastonguay
Mediation analysis is used in genetic mapping studies to identify candidate gene mediators of quantitative trait loci (QTL). We consider genetic mediation analysis of triplets-sets of three variables consisting of a target trait, the genoty...
Vir1p, the yeast homolog of virilizer, is required for mRNA m6A methylation and meiosis [0.03%]
酿酒酵母mRNA甲基化和减数分裂所需的雄性素同源物Vir1p
Zachory M Park,Ethan Belnap,Matthew Remillard et al.
Zachory M Park et al.
N6-Methyladenosine (m6A) is among the most abundant modifications of eukaryotic mRNAs. mRNA methylation regulates many biological processes including playing an essential role in meiosis. During meiosis in the budding yeast, Saccharomyces c...