Genetic and genomic analyses of Drosophila melanogaster models of chromatin modification disorders [0.03%]
染色质修饰障碍的果蝇模型的遗传和基因组分析
Rebecca A MacPherson,Vijay Shankar,Robert R H Anholt et al.
Rebecca A MacPherson et al.
Switch/sucrose nonfermentable (SWI/SNF)-related intellectual disability disorders (SSRIDDs) and Cornelia de Lange syndrome are rare syndromic neurodevelopmental disorders with overlapping clinical phenotypes. SSRIDDs are associated with the...
Laura L Colbran,Fabian C Ramos-Almodovar,Iain Mathieson
Laura L Colbran
Most variants identified in human genome-wide association studies and scans for selection are noncoding. Interpretation of their effects and the way in which they contribute to phenotypic variation and adaptation in human populations is the...
DMKPs provide a generalizable strategy for studying genes required for reproduction or viability in nontraditional model organisms [0.03%]
DMKP为在非传统模型生物中研究繁殖或存活所需基因提供了一种可扩展的策略
Willem J Laursen,Rachel Busby,Tatevik Sarkissian et al.
Willem J Laursen et al.
The advent of CRISPR/Cas9-mediated genome editing has expanded the range of animals amenable to targeted genetic analysis. This has accelerated research in animals not traditionally studied using molecular genetics. However, studying genes ...
Impact of interpopulation distance on dominance variance and average heterosis in hybrid populations within species [0.03%]
种内杂交群体间群体距离对显性变异和平均杂种优势的影响
Andrés Legarra,David Omar Gonzalez-Dieguez,Alain Charcosset et al.
Andrés Legarra et al.
Interpopulation improvement for crosses of close populations in crops and livestock depends on the amount of heterosis and the amount of variance of dominance deviations in the hybrids. It has been intuited that the further the distance bet...
Causes and consequences of linkage disequilibrium among transposable elements within eukaryotic genomes [0.03%]
真核生物基因组中转座元件之间的连锁不平衡的成因和后果
Denis Roze
Denis Roze
Sex and recombination can affect the dynamics of transposable elements (TEs) in various ways: while sex is expected to help TEs to spread within populations, the deleterious effect of ectopic recombination among transposons represents a pos...
Dicentric chromosome breakage in Drosophila melanogaster is influenced by pericentric heterochromatin and occurs in nonconserved hotspots [0.03%]
异染色质和非保守位点影响果蝇臂间倒位染色体的断裂频率
Hunter J Hill,Danielle Bonser,Kent G Golic
Hunter J Hill
Chromosome breakage plays an important role in the evolution of karyotypes and can produce deleterious effects within a single individual, such as aneuploidy or cancer. Forces that influence how and where chromosomes break are not fully und...
The frequency and differential pleiotropy of phenotypic nonspecificity in Drosophila melanogaster [0.03%]
果蝇中表型非特异性的频率和性状偏显性分析结果
Anthony Percival-Smith,Sheng Cheng,Kassie Ouellette
Anthony Percival-Smith
The regulation of the initiation of transcription by transcription factors is often assumed to be dependent on specific recognition of DNA-binding sites and nonredundant. However, the redundant induction or rescue of a phenotype by transcri...
GBScleanR: robust genotyping error correction using a hidden Markov model with error pattern recognition [0.03%]
GBScleanR：使用错误模式识别的隐马尔可夫模型进行鲁棒基因分型错误修正
Tomoyuki Furuta,Toshio Yamamoto,Motoyuki Ashikari
Tomoyuki Furuta
Reduced-representation sequencing (RRS) provides cost-effective and time-saving genotyping platforms. Despite the outstanding advantage of RRS in throughput, the obtained genotype data usually contain a large number of errors. Several error...
Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos [0.03%]
精子来源的中心粒在4细胞期芽殖线虫胚胎中随机分离进入芽球中
Pierre Gönczy,Fernando R Balestra
Pierre Gönczy
Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of other cellular constituents is unequal between the 2 gametes. Thus, 2 copies of the centriole are contributed solely by t...
An exponential increase in QTL detection with an increased sample size [0.03%]
随着样本量的增加 基因定位数目呈指数型上升规律
Apurva S Chitre,Oksana Polesskaya,Daniel Munro et al.
Apurva S Chitre et al.
Power analyses are often used to determine the number of animals required for a genome-wide association study (GWAS). These analyses are typically intended to estimate the sample size needed for at least 1 locus to exceed a genome-wide sign...