A screen for stress-induced sleep genes in C. elegans reveals a role for glutamate signaling [0.03%]
模式动物线虫应激诱导睡眠的分子机制研究取得进展
Quinn Howe,Caroline Kominick,Mercedes Pierce et al.
Quinn Howe et al.
Sleep is an essential behavioral state that evolved early in animals, possibly with the advent of the nervous system. The complexity of sleep neural networks varies significantly across phylogeny, yet common signaling molecules exist. Stres...
Colin LaMont
Colin LaMont
In resource-constrained populations, the growth rate of an allele is coupled to the frequency of its competitors. Since these frequencies are unobserved, exact inference of evolutionary parameters demands integrating over the full ensemble ...
Deciphering subcellular localization-dependent functions of Hog1 MAPK in Cryptococcus neoformans [0.03%]
新形隐球菌中Hog1丝裂原活化蛋白激酶的亚细胞定位依赖性功能解析
Yu-Byeong Jang,Yong-Sun Bahn
Yu-Byeong Jang
The Hog1 mitogen-activated protein kinase regulates stress adaptation, sexual differentiation, and virulence traits by dynamically shuttling between the cytoplasm and nucleus in the fungal pathogen Cryptococcus neoformans, a leading cause o...
Rhythmic Nuclear Import Mediated by Importins Regulates the Neurospora Circadian Clock [0.03%]
节律性核输入调控曲霉钟表 механизмы ритмичной трансляции ядерного импорта转运蛋白调节曲霉钟表
Ziyan Wang,Bin Wang,Bradley M Bartholomai et al.
Ziyan Wang et al.
Circadian clocks in eukaryotes rely on precisely regulated negative feedback loops to generate daily rhythms. However, the delay mechanisms that extend this structurally simple feedback loop to ∼24 hours are not yet fully understood. In th...
CRISPR screening identifies TRIM27 as a destabilizer of the Smith-Magenis syndrome protein RAI1 [0.03%]
利用 CRISPR 筛选鉴定出一种新型 E3 连接酶 TRIM27 可导致 SMS 核心蛋白 RAI1 不稳定脱落
Yu Cheng Lin,Yu-Ju Lee,Catherine Xinrui Li et al.
Yu Cheng Lin et al.
The nervous system is highly sensitive to alterations in the dosage of genes crucial for neurodevelopment, as exemplified by retinoic acid-induced 1 (RAI1). A 50% change in RAI1 gene copy number, resulting in either reduced or increased pro...
A classification of structured coalescent processes with migration, conditional on the population pedigree [0.03%]
条件为人口谱系的结构化基因alogy过程的分类与迁移有关
Sabin Lessard,Terry Easlick,John Wakeley
Sabin Lessard
Organismal genealogies or pedigrees of populations may have strong effects on patterns of variation. We extend recent analyses of the effects that pedigrees have on times to common ancestry to cases of population subdivision and migration. ...
Regulation of axon outgrowth during mushroom body development by acetylated α-tubulin lysine 394 and tau [0.03%]
乙酰化α-微管蛋白赖氨酸394和tau调节蘑菇体发育期间轴突的生长出来
Chloe J Welch,Liam O&#x;Connor Mueller,Sophia P Trujillo et al.
Chloe J Welch et al.
Disruptions in the microtubule cytoskeleton play a role in various neurological diseases that afflict a large fraction of the population. Microtubule function is regulated by post-translational modifications like acetylation, and one consis...
Cox-MK: a model-X knockoff framework for genome-wide survival association analysis [0.03%]
Cox-MK：一种针对全基因组生存关联分析的模型X敲除框架
Lin Hu,Chen Yang,Zihuan Tang et al.
Lin Hu et al.
In genome-wide survival association studies, time-to-event (TTE) phenotypes are often underutilized due to the challenges of large-scale multiple testing under linkage disequilibrium and heavy censoring. We propose Cox-MK, a novel genome-wi...
Regulation of somatic stem cell development through positional and proliferative signals during Drosophila melanogaster pupal ovary development resembles the framework governing adult stem cell behavior [0.03%]
果蝇拟雌虫腹板卵巢发育期间通过定位和增殖信号调节体干细胞发育，与调控成年干细胞行为的框架类似
Rachel Misner,Amy Reilein,Helen V Kogan et al.
Rachel Misner et al.
Follicle stem cells (FSCs) in the Drosophila melanogaster ovary are maintained through independent regulation of division and differentiation to become proliferative follicle cells (FCs) to their posterior or quiescent escort cells (ECs) to...
Kernel-smoothed permutation for extreme p-value estimation in genetic association studies [0.03%]
遗传关联研究中用于估计极端P值的核平滑置换法
Jiayi Bian,Jingjing Wu,M Ethan MacDonald et al.
Jiayi Bian et al.
In genetic association studies, permutation tests serve as a cornerstone to estimate p-values. This is because researchers may design new test statistics without a known closed-form distribution, or the assumption of a well-established test...