TF2TG: an online resource mining the potential gene targets of transcription factors in Drosophila [0.03%]
TF2TG：一个在线资源挖掘转录因子在果蝇中的潜在基因目标站点
Yanhui Hu,Jonathan Rodiger,Yifang Liu et al.
Yanhui Hu et al.
Sequence-specific transcription factors (TFs) are key regulators of many biological processes, controlling the expression of their target genes through binding to the cis- regulatory regions such as promoters and enhancers. Each TF has uniq...
Proximity labeling identification of plasma membrane eisosome proteins in Candida albicans [0.03%]
白色念珠菌邻近标记鉴定细胞膜eisosomes蛋白
Carla E Lanze,John D Haley,James B Konopka
Carla E Lanze
The ability of Candida albicans to resist stressful conditions in the host and grow invasively into tissues contributes to the virulence of this human fungal pathogen. Plasma membrane subdomains known as the MCC (Membrane Compartment of Can...
Improved sampling of genotypes and species reveals new insights on de novo gene history and regulatory origins [0.03%]
改进的基因型和物种采样揭示了关于从头基因历史和调控起源的新见解
Logan Blair,Julie Cridland,Yige Luo et al.
Logan Blair et al.
The evolution of genes de novo from ancestrally nongenic sequences may be a significant mechanism of gene origin. Many studies have focused on identifying de novo genes in distant evolutionary comparisons, which bias the sample of de novo g...
Lauren M McIntyre
Lauren M McIntyre
A multigenerational population-growth assay to capture subtle fitness phenotypes in C. elegans and other nematodes [0.03%]
一种多世代种群增长测定方法，用于检测秀丽隐杆线虫和其他线虫的微小适应性表型
Sophia C Tintori,Derin Çağlar,Matthew V Rockman
Sophia C Tintori
Heritable fitness differences between individuals are the currency of evolution but can be challenging to quantify with precision. A slight probabilistic fitness advantage to one relatively healthy individual over another is often too subtl...
Testing for differences in polygenic scores in the presence of confounding [0.03%]
混杂因素存在下的多基因得分差异检验
Jennifer Blanc,Jeremy J Berg
Jennifer Blanc
Polygenic scores have become an important tool in human genetics, enabling the prediction of individuals' phenotypes from their genotypes. Understanding how the pattern of differences in polygenic score predictions across individuals inters...
Living in poverty is associated with gene expression changes in immune cells [0.03%]
生活在贫困中与免疫细胞的基因表达变化有关
Nicole S Arnold,Justyna Resztak,David Witonsky et al.
Nicole S Arnold et al.
Social factors influence health outcomes and life expectancy. Individuals living in poverty often have adverse health outcomes related to chronic inflammation that affect the cardiovascular, renal, and pulmonary systems. Negative psychosoci...
Alternate genetic paths of adaptation to spectinomycin in Escherichia coli [0.03%]
大肠杆菌适应spectinomycin的替代遗传途径
Chinmaya Jena,Soham Deolankar,Nishad Matange
Chinmaya Jena
Unregulated antibiotic use leads to their accumulation in the environment at sub-lethal levels, facilitating the evolution of antimicrobial resistance in bacteria. Antibiotics used in farms and veterinary medicine are frequently detected in...
Eric Lieberman Greer,Siu Sylvia Lee,Veena Prahlad
Eric Lieberman Greer
This book chapter will focus on modifications to chromatin itself, how chromatin modifications are regulated, and how these modifications are deciphered by the cell to impact aging. In this chapter, we will review how chromatin modification...
Filip Thor,Carl Nettelblad
Filip Thor
We introduce a framework for using contrastive learning for dimensionality reduction on genetic datasets to create PCA-like population visualizations. Contrastive learning is a self-supervised deep learning method that uses similarities bet...