Timesweeper: accurately identifying selective sweeps using population genomic time series [0.03%]
精准识别选择淘汰的时机：利用群体基因组时间序列
Logan S Whitehouse,Daniel R Schrider
Logan S Whitehouse
Despite decades of research, identifying selective sweeps, the genomic footprints of positive selection, remains a core problem in population genetics. Of the myriad methods that have been developed to tackle this task, few are designed to ...
Timothy A Currier,Michelle M Pang,Thomas R Clandinin
Timothy A Currier
Originally a genetic model organism, the experimental use of Drosophila melanogaster has grown to include quantitative behavioral analyses, sophisticated perturbations of neuronal function, and detailed sensory physiology. A highlight of th...
Mary L Kaldunski,Jennifer R Smith,Kent C Brodie et al.
Mary L Kaldunski et al.
Rare diseases individually affect relatively few people, but as a group they impact considerable numbers of people. The Rat Genome Database (https://rgd.mcw.edu) is a knowledgebase that offers resources for rare disease research. This inclu...
A comprehensive map of hotspots of de novo telomere addition in Saccharomyces cerevisiae [0.03%]
酿酒酵母新生端粒添加热点的详图
Katrina Ngo,Tristen H Gittens,David I Gonzalez et al.
Katrina Ngo et al.
Telomere healing occurs when telomerase, normally restricted to chromosome ends, acts upon a double-strand break to create a new, functional telomere. De novo telomere addition (dnTA) on the centromere-proximal side of a break truncates the...
Artyom A Alekseyenko,Barry M Zee,Zuzer Dhoondia et al.
Artyom A Alekseyenko et al.
Aberrant transcriptional programming and chromatin dysregulation are common to most cancers. Whether by deranged cell signaling or environmental insult, the resulting oncogenic phenotype is typically manifested in transcriptional changes ch...
Tissue-specific chromatin-binding patterns of Caenorhabditis elegans heterochromatin proteins HPL-1 and HPL-2 reveal differential roles in the regulation of gene expression [0.03%]
Caenorhabditis elegans 异染色质蛋白HPL-1和HPL-2的组织特异性染色体结合模式揭示了其在基因表达调控中的不同作用
Patricia de la Cruz-Ruiz,María Jesús Rodríguez-Palero,Peter Askjaer et al.
Patricia de la Cruz-Ruiz et al.
Heterochromatin is characterized by an enrichment of repetitive elements and low gene density and is often maintained in a repressed state across cell division and differentiation. The silencing is mainly regulated by repressive histone mar...
Evolution of a new form of haploid-specific gene regulation appearing in a limited clade of ascomycete yeast species [0.03%]
子囊菌门酵母类群中一种新的单倍体特异性基因调控形式的进化
Francesca Del Frate,Megan E Garber,Alexander D Johnson
Francesca Del Frate
Over evolutionary timescales, the logic and pattern of cell-type specific gene expression can remain constant, yet the molecular mechanisms underlying such regulation can drift between alternative forms. Here, we document a new example of t...
Developmental expression of the Sturge-Weber syndrome-associated genetic mutation in Gnaq: a formal test of Happle's paradominant inheritance hypothesis [0.03%]
GNAQ基因相关遗传突变在斯特奇-韦伯综合征中的发育表达：对Happle提出的“半显性遗传假说”的正式检验
Sarah E Wetzel-Strong,Francesca Galeffi,Christian Benavides et al.
Sarah E Wetzel-Strong et al.
Sturge-Weber Syndrome (SWS) is a sporadic (non-inherited) syndrome characterized by capillary vascular malformations in the facial skin, leptomeninges, or the choroid. A hallmark feature is the mosaic nature of the phenotype. SWS is caused ...
Genome-wide temperature-sensitivity of Polycomb group regulation and reduction thereof in temperate Drosophila melanogaster [0.03%]
多梳染色质调控的全基因组温度敏感性和果蝇实验种群对其的缓解
Susanne Voigt,Christin Froschauer
Susanne Voigt
Epigenetic regulation varies with the environment. In the fruit fly Drosophila melanogaster, environmental temperature can affect chromatin-based gene regulation. Genes regulated by the Polycomb group can vary in their transcriptional outpu...
Weaker selection on genes with treatment-specific expression consistent with a limit on plasticity evolution in Arabidopsis thaliana [0.03%]
具有特定治疗表达的基因的选择压力较小，这与拟南芥中限制可塑性进化一致
Miles Roberts,Emily B Josephs
Miles Roberts
Differential gene expression between environments often underlies phenotypic plasticity. However, environment-specific expression patterns are hypothesized to relax selection on genes, and thus limit plasticity evolution. We collated over 2...