Natural variation in codon bias and mRNA folding strength interact synergistically to modify protein expression in Saccharomyces cerevisiae [0.03%]
酿酒酵母中密码偏爱性和mRNA二级结构强度的自然变异相互作用以协同的方式调节蛋白质表达
Anastacia N Wienecke,Margaret L Barry,Daniel A Pollard
Anastacia N Wienecke
Codon bias and mRNA folding strength (mF) are hypothesized molecular mechanisms by which polymorphisms in genes modify protein expression. Natural patterns of codon bias and mF across genes as well as effects of altering codon bias and mF s...
How flower development genes were identified using forward genetic screens in Arabidopsis thaliana [0.03%]
拟南芥开花发育相关基因的正向遗传学筛选鉴定进展
David R Smyth
David R Smyth
In the later part of the 1980s, the time was ripe for identifying genes controlling flower development. In that pregenomic era, the easiest way to do this was to induce random mutations in seeds by chemical mutagens (or irradiation) and to ...
Gabriela Lobinska,Yitzhak Pilpel,Yoav Ram
Gabriela Lobinska
The mutation rate plays an important role in adaptive evolution. It can be modified by mutator and anti-mutator alleles. Recent empirical evidence hints that the mutation rate may vary among genetically identical individuals: evidence from ...
An angiotensin converting enzyme homolog is required for volatile pheromone detection, odorant binding protein secretion and normal courtship behavior in Drosophila melanogaster [0.03%]
果蝇中一个血管紧张素转换酶同源物是其挥发性信息素检测、气味结合蛋白分泌及正常求偶行为的必要条件
Tal Soo Ha,Samarpita Sengupta,Jordan Powell et al.
Tal Soo Ha et al.
In many arthropods, including insects responsible for transmission of human diseases, behaviors that include mating, aggregation, and aggression are triggered by detection of pheromones. Extracellular odorant binding proteins are critical f...
Reduced histone gene copy number disrupts Drosophila Polycomb function [0.03%]
组蛋白基因拷贝数减少会扰乱果蝇Polycomb功能
Jeanne-Marie E McPherson,Lucy C Grossmann,Harmony R Salzler et al.
Jeanne-Marie E McPherson et al.
The chromatin of animal cells contains two types of histones: canonical histones that are expressed during S phase of the cell cycle to package the newly replicated genome, and variant histones with specialized functions that are expressed ...
A dual, catalytic role for the fission yeast Ccr4-Not complex in gene silencing and heterochromatin spreading [0.03%]
裂殖酵母Ccr4-Not复合体在基因沉默和异染色质扩散中具有双重催化作用
Drice Challal,Alexandra Menant,Can Goksal et al.
Drice Challal et al.
Heterochromatic gene silencing relies on combinatorial control by specific histone modifications, the occurrence of transcription, and/or RNA degradation. Once nucleated, heterochromatin propagates within defined chromosomal regions and is ...
Paul D Blischak,Mathews Sajan,Michael S Barker et al.
Paul D Blischak et al.
Polyploidy is an important generator of evolutionary novelty across diverse groups in the Tree of Life, including many crops. However, the impact of whole-genome duplication depends on the mode of formation: doubling within a single lineage...
A primary microcephaly-associated sas-6 mutation perturbs centrosome duplication, dendrite morphogenesis, and ciliogenesis in Caenorhabditis elegans [0.03%]
一种与原发性小头畸形相关的sas-6突变干扰了秀丽隐杆线虫的中心体复制、树突形态生成和纤毛发生
Mary Bergwell,Amy Smith,Ellie Smith et al.
Mary Bergwell et al.
The human SASS6(I62T) missense mutation has been linked with the incidence of primary microcephaly in a Pakistani family, although the mechanisms by which this mutation causes disease remain unclear. The SASS6(I62T) mutation corresponds to ...
Ribosomal protein mutations and cell competition: autonomous and nonautonomous effects on a stress response [0.03%]
核糖体蛋白突变与细胞竞争：应激反应的自主和非自主效应
Marianthi Kiparaki,Nicholas E Baker
Marianthi Kiparaki
Ribosomal proteins (Rps) are essential for viability. Genetic mutations affecting Rp genes were first discovered in Drosophila, where they represent a major class of haploinsufficient mutations. One mutant copy gives rise to the dominant "M...
Inês B Santos,Alan Wainman,Juan Garrido-Maraver et al.
Inês B Santos et al.
Gamete formation is essential for sexual reproduction in metazoans. Meiosis in males gives rise to spermatids that must differentiate and individualize into mature sperm. In Drosophila melanogaster, individualization of interconnected sperm...