Long noncoding RNAs contribute to DNA damage resistance in Arabidopsis thaliana [0.03%]
拟南芥长非编码RNA通过多种机制提高DNA损伤耐受性
Nathalie Durut,Aleksandra E Kornienko,Heiko A Schmidt et al.
Nathalie Durut et al.
Efficient repair of DNA lesions is essential for the faithful transmission of genetic information between somatic cells and for genome integrity across generations. Plants have multiple, partially redundant, and overlapping DNA repair pathw...
Clusters of acidic and hydrophobic residues can predict acidic transcriptional activation domains from protein sequence [0.03%]
酸性及疏水性氨基酸聚集体可预测转录活化域中的酸性区域
Sanjana R Kotha,Max Valentín Staller
Sanjana R Kotha
Transcription factors activate gene expression in development, homeostasis, and stress with DNA binding domains and activation domains. Although there exist excellent computational models for predicting DNA binding domains from protein sequ...
Somatic mutations inferred from RNA-seq data highlight the contribution of replication timing to mutation rate variation in a model plant [0.03%]
基于RNA-seq数据推测的体细胞突变表明复制时间对模型植物突变率变异的影响
Patrick M Staunton,Andrew J Peters,Cathal Seoighe
Patrick M Staunton
Variation in the rates and characteristics of germline and somatic mutations across the genome of an organism is informative about DNA damage and repair processes and can also shed light on aspects of organism physiology and evolution. We a...
Nicholas H Barton,Alison M Etheridge,Amandine Véber
Nicholas H Barton
The classical infinitesimal model is a simple and robust model for the inheritance of quantitative traits. In this model, a quantitative trait is expressed as the sum of a genetic and an environmental component, and the genetic component of...
Identification and characterization of protein interactions with the major Niemann-Pick type C disease protein in yeast reveals pathways of therapeutic potential [0.03%]
鉴定并表征酵母中主要的尼曼匹克病C型蛋白相互作用及对该蛋白的作用途径进行研究以发现具有治疗潜力的方法
Natalie Hammond,Jamie Snider,Igor Stagljar et al.
Natalie Hammond et al.
Niemann-Pick type C (NP-C) disease is a rare lysosomal storage disease caused by mutations in NPC1 (95% cases) or NPC2 (5% cases). These proteins function together in cholesterol egress from the lysosome, whereby upon mutation, cholesterol ...
Opi1-mediated transcriptional modulation orchestrates genotoxic stress response in budding yeast [0.03%]
Opi1介导的转录调控协调芽殖酵母中的致突变胁迫反应
Giovanna Marques Panessa,Eduardo Tassoni-Tsuchida,Marina Rodrigues Pires et al.
Giovanna Marques Panessa et al.
In budding yeast, the transcriptional repressor Opi1 regulates phospholipid biosynthesis by repressing expression of genes containing inositol-sensitive upstream activation sequences. Upon genotoxic stress, cells activate the DNA damage res...
Samantha Petti,Gautam Reddy,Michael M Desai
Samantha Petti
Correlation among multiple phenotypes across related individuals may reflect some pattern of shared genetic architecture: individual genetic loci affect multiple phenotypes (an effect known as pleiotropy), creating observable relationships ...
The Caenorhabditis elegans cullin-RING ubiquitin ligase CRL4DCAF-1 is required for proper germline nucleolus morphology and male development [0.03%]
秀丽杆线虫CRL4DCAF-1泛素连接酶复合物是规范生殖细胞核仁形态和雄性发育的必要条件
Mohammad M Rahman,Riju S Balachandran,Jonathan B Stevenson et al.
Mohammad M Rahman et al.
Cullin-RING ubiquitin ligases (CRLs) are the largest class of ubiquitin ligases with diverse functions encompassing hundreds of cellular processes. Inactivation of core components of the CRL4 ubiquitin ligase produces a germ cell defect in ...
The transcriptional regulator Ume6 is a major driver of early gene expression during gametogenesis [0.03%]
转录调节因子Ume6是配子发生早期基因表达的主要驱动因素
Anthony Harris,Elçin Ünal
Anthony Harris
The process of gametogenesis is orchestrated by a dynamic gene expression program, where a vital subset constitutes the early meiotic genes. In budding yeast, the transcription factor Ume6 represses early meiotic gene expression during mito...
Genetic control of the error-prone repair of a chromosomal double-strand break with 5' overhangs in yeast [0.03%]
酵母染色体5'悬垂双链断裂的错误修复的遗传调控
Samantha Shaltz,Sue Jinks-Robertson
Samantha Shaltz
A targeted double-strand break introduced into the genome of Saccharomyces cerevisiae is repaired by the relatively error-prone nonhomologous end joining (NHEJ) pathway when homologous recombination is not an option. A zinc finger nuclease ...