Highlighting rare disease research with a GENETICS and G3 series on genetic models of rare diseases [0.03%]
借助GENETICS和G3系列研究罕见病的遗传模型以促进罕见疾病的研究
Philip Hieter,Brenda Andrews,Douglas Fowler et al.
Philip Hieter et al.
Widespread priming of transcriptional regulatory elements by incipient accessibility or RNA polymerase II pause in early embryos of the sea urchin Strongylocentrotus purpuratus [0.03%]
海胆Strongylocentrotus purpuratus早期胚胎中转录调控元件的广泛预激活是由染色质可接近性或RNA聚合酶II暂停引起的
Cesar Arenas-Mena,Serhat Akin
Cesar Arenas-Mena
Transcriptional regulatory elements (TREs) are the primary nodes that control developmental gene regulatory networks. In embryo stages, larvae, and adult differentiated red spherule cells of the sea urchin Strongylocentrotus purpuratus, tra...
Ilse Höllinger,Benjamin Wölfl,Joachim Hermisson
Ilse Höllinger
Rapid phenotypic adaptation is widespread in nature, but the underlying genetic dynamics remain controversial. Whereas population genetics envisages sequential beneficial substitutions, quantitative genetics assumes a collective response th...
Hyperactive Ras disrupts cell size control and a key step in cell cycle entry in budding yeast [0.03%]
活化Ras干扰芽殖酵母的细胞生长控制及细胞周期起始的关键步骤
Jerry T DeWitt,Jennifer C Chinwuba,Douglas R Kellogg
Jerry T DeWitt
Severe defects in cell size are a nearly universal feature of cancer cells. However, the underlying causes are unknown. A previous study suggested that a hyperactive mutant of yeast Ras (ras2G19V) that is analogous to the human Ras oncogene...
The long-term effects of genomic selection: 2. Changes in allele frequencies of causal loci and new mutations [0.03%]
基因组选择的长期效应研究二：因果位点等位基因频率的变化及新突变的影响
Yvonne C J Wientjes,Piter Bijma,Joost van den Heuvel et al.
Yvonne C J Wientjes et al.
Genetic selection has been applied for many generations in animal, plant, and experimental populations. Selection changes the allelic architecture of traits to create genetic gain. It remains unknown whether the changes in allelic architect...
Shailja Singh,Xinyi Hu,Christina Dixelius
Shailja Singh
Advances in sequencing technologies and bioinformatic analyses are accelerating the quantity and quality of data from all domains of life. This rich resource has the potential to reveal a number of important incidences with respect to possi...
Germline progenitors and oocyte production in the honeybee queen ovary [0.03%]
蜜蜂蜂后卵巢的生殖干细胞及卵母细胞产生过程
Georgia Cullen,Joshua B Gilligan,Joseph G Guhlin et al.
Georgia Cullen et al.
Understanding the reproduction of honeybee queens is crucial to support populations of this economically important insect. Here we examine the structure of the honeybee ovary to determine the nature of the germline progenitors in the ovary....
Genetics of evolved load resistance in the skeletons of unusually large mice from Gough Island [0.03%]
戈夫岛异常大的老鼠骨骼进化负荷抵抗的遗传学
Bret A Payseur,Sara Anderson,Roy T James et al.
Bret A Payseur et al.
A primary function of the skeleton is to resist the loads imparted by body weight. Genetic analyses have identified genomic regions that contribute to differences in skeletal load resistance between laboratory strains of mice, but these stu...
Sleep need, the key regulator of sleep homeostasis, is indicated and controlled by phosphorylation of threonine 221 in salt-inducible kinase 3 [0.03%]
睡眠需求通过盐诱导型激酶3第221位苏氨酸的磷酸化得到指示和控制：睡眠稳态的关键调节因子
Yang Li,Chengang Li,Yuxiang Liu et al.
Yang Li et al.
Sleep need drives sleep and plays a key role in homeostatic regulation of sleep. So far sleep need can only be inferred by animal behaviors and indicated by electroencephalography (EEG). Here we report that phosphorylation of threonine (T) ...
Domains and residues of the Saccharomyces cerevisiae hnRNP protein Hrp1 important for transcriptional autoregulation and noncoding RNA termination [0.03%]
重要调控Saccharomyces cerevisiae的hnRNP蛋白Hrp1的转录自调节和非编码RNA终止的结构域和残基
Emma C Goguen,David A Brow
Emma C Goguen
Proteins that bind the nascent transcript exiting RNA polymerase II can regulate transcription elongation. The essential Saccharomyces cerevisiae hnRNP protein Hrp1 is one such protein and participates in both cleavage and polyadenylation-c...