Genomic mechanisms and consequences of diverse postzygotic barriers between monkeyflower species [0.03%]
monkeyflower物种间多样性的合子后生殖隔离的基因组机制及后果
V Alex Sotola,Colette S Berg,Matthew Samuli et al.
V Alex Sotola et al.
The evolution of genomic incompatibilities causing postzygotic barriers to hybridization is a key step in species divergence. Incompatibilities take 2 general forms-structural divergence between chromosomes leading to severe hybrid sterilit...
Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b [0.03%]
使用GnuMoM2b搜索和可视化妊娠性状的遗传关联
Qi Yan,Rafael F Guerrero,Raiyan R Khan et al.
Qi Yan et al.
Adverse pregnancy outcomes (APOs) are major risk factors for women's health during pregnancy and even in the years after pregnancy. Due to the heterogeneity of APOs, only few genetic associations have been identified. In this report, we con...
Electric shock causes a fleeing-like persistent behavioral response in the nematode Caenorhabditis elegans [0.03%]
电击可导致秀丽隐杆线虫产生类似逃避的持久性行为反应
Ling Fei Tee,Jared J Young,Keisuke Maruyama et al.
Ling Fei Tee et al.
Behavioral persistency reflects internal brain states, which are the foundations of multiple brain functions. However, experimental paradigms enabling genetic analyses of behavioral persistency and its associated brain functions have been l...
Two disulfide-reducing pathways are required for the maturation of plastid c-type cytochromes in Chlamydomonas reinhardtii [0.03%]
裂殖壶菌叶绿体c型细胞色素成熟需要两种半胱氨酸还原途径
Ankita Das,Nitya Subrahmanian,Stéphane T Gabilly et al.
Ankita Das et al.
In plastids, conversion of light energy into ATP relies on cytochrome f, a key electron carrier with a heme covalently attached to a CXXCH motif. Covalent heme attachment requires reduction of the disulfide-bonded CXXCH by CCS5 and CCS4. CC...
Two independent DNA repair pathways cause mutagenesis in template switching deficient Saccharomyces cerevisiae [0.03%]
两种独立的DNA修复途径可导致模板切换缺陷的Saccharomyces cerevisiae发生突变
Yangyang Kate Jiang,Eleanor A Medley,Grant W Brown
Yangyang Kate Jiang
Upon DNA replication stress, cells utilize the postreplication repair pathway to repair single-stranded DNA and maintain genome integrity. Postreplication repair is divided into 2 branches: error-prone translesion synthesis, signaled by pro...
Autophagy impairment and lifespan reduction caused by Atg1 RNAi or Atg18 RNAi expression in adult fruit flies (Drosophila melanogaster) [0.03%]
抑制自噬基因Atg1或Atg18延长果蝇寿命
Mariah Bierlein,Joseph Charles,Trevor Polisuk-Balfour et al.
Mariah Bierlein et al.
Autophagy, an autophagosome and lysosome-based eukaryotic cellular degradation system, has previously been implicated in lifespan regulation in different animal models. In this report, we show that expression of the RNAi transgenes targetin...
Leveraging osteoclast genetic regulatory data to identify genes with a role in osteoarthritis [0.03%]
利用破骨细胞遗传调控数据识别在骨关节炎中发挥作用的基因
Benjamin H Mullin,Kun Zhu,Suzanne J Brown et al.
Benjamin H Mullin et al.
There has been a growing interest in the role of the subchondral bone and its resident osteoclasts in the progression of osteoarthritis (OA). A recent genome-wide association study (GWAS) identified 100 independent association signals for O...
Biochemical pathways represented by Gene Ontology-Causal Activity Models identify distinct phenotypes resulting from mutations in pathways [0.03%]
由基因本体论因果活性模型表示的生化途径可识别途径中突变产生的不同表型
David P Hill,Harold J Drabkin,Cynthia L Smith et al.
David P Hill et al.
Gene inactivation can affect the process(es) in which that gene acts and causally downstream ones, yielding diverse mutant phenotypes. Identifying the genetic pathways resulting in a given phenotype helps us understand how individual genes ...
Caenorhabditis elegans NSE3 homolog (MAGE-1) is involved in genome stability and acts in inter-sister recombination during meiosis [0.03%]
线虫NSE3同源物(MAGE-1)与基因组稳定性有关并在减数分裂中参与间期 sister strand交换作用
Arome Solomon Odiba,Guiyan Liao,Chiemekam Samuel Ezechukwu et al.
Arome Solomon Odiba et al.
Melanoma antigen (MAGE) genes encode for a family of proteins that share a common MAGE homology domain. These genes are conserved in eukaryotes and have been linked to a variety of cellular and developmental processes including ubiquitinati...
Natural methylation epialleles correlate with gene expression in maize [0.03%]
自然甲基化表型等位基因与玉米基因表达相关性研究
Yibing Zeng,R Kelly Dawe,Jonathan I Gent
Yibing Zeng
DNA methylation in plants is depleted from cis-regulatory elements in and near genes but is present in some gene bodies, including exons. Methylation in exons solely in the CG context is called gene body methylation (gbM). Methylation in ex...