Forward genetic screen of Caenorhabditis elegans mutants with impaired sleep reveals a crucial role of neuronal diacylglycerol kinase DGK-1 in regulating sleep [0.03%]
利用正向遗传筛选揭示神经酰基甘油激酶DGK-1在调节线虫睡眠中的重要作用
Chung-Kuan Chen,Taizo Kawano,Masashi Yanagisawa et al.
Chung-Kuan Chen et al.
The sleep state is widely observed in animals. The molecular mechanisms underlying sleep regulation, however, remain largely unclear. In the nematode Caenorhabditis elegans, developmentally timed sleep (DTS) and stress-induced sleep (SIS) a...
Linnea C Wethekam,Jeffrey K Moore
Linnea C Wethekam
Across eukaryotic genomes, multiple α- and β-tubulin genes require regulation to ensure sufficient production of tubulin heterodimers. Features within these gene families that regulate expression remain underexplored. Here, we investigate...
Structural variants and short tandem repeats impact gene expression and splicing in bovine testis tissue [0.03%]
结构变异和短串联重复影响公牛睾丸组织中的基因表达及剪接
Meenu Bhati,Xena Marie Mapel,Audald Lloret-Villas et al.
Meenu Bhati et al.
Structural variants (SVs) and short tandem repeats (STRs) are significant sources of genetic variation. However, the impacts of these variants on gene regulation have not been investigated in cattle. Here, we genotyped and characterized 19,...
Cornelia de Lange Syndrome mutations in SMC1A cause cohesion defects in yeast [0.03%]
SMC1A中的科内利亚·德朗热综合症突变导致酵母中黏连缺陷
Jingrong Chen,Erin N Floyd,Dean S Dawson et al.
Jingrong Chen et al.
Cornelia de Lange Syndrome (CdLS) is a developmental disorder characterized by limb truncations, craniofacial abnormalities, and cognitive delays. CdLS is caused mainly by mutations in genes encoding subunits or regulators of the cohesin co...
ZIF-1-mediated degradation of zinc finger proteins in the Caenorhabditis elegans germ line [0.03%]
锌指结构域结合模体通过C. elegans中的ZIF-1介导的蛋白质降解被降解
Aaron Z A Schwartz,Yusuff Abdu,Jeremy Nance
Aaron Z A Schwartz
Rapid and conditional protein depletion is the gold standard genetic tool for deciphering the molecular basis of developmental processes. Previously, we showed that by conditionally expressing the E3 ligase substrate adaptor ZIF-1 in Caenor...
Mitochondrial superoxide dismutase Sod2 suppresses nuclear genome instability during oxidative stress [0.03%]
氧化应激下线粒体超氧化物歧化酶Sod2抑制核基因组不稳定性
Sonia Vidushi Gupta,Lillian Campos,Kristina Hildegard Schmidt
Sonia Vidushi Gupta
Oxidative stress can damage DNA and thereby contribute to genome instability. To avoid an imbalance or overaccumulation of reactive oxygen species (ROS), cells are equipped with antioxidant enzymes that scavenge excess ROS. Cells lacking th...
Meiosis in budding yeast [0.03%]
芽裂酵母的减数分裂
G Valentin Börner,Andreas Hochwagen,Amy J MacQueen
G Valentin Börner
Meiosis is a specialized cell division program that is essential for sexual reproduction. The two meiotic divisions reduce chromosome number by half, typically generating haploid genomes that are packaged into gametes. To achieve this ploid...
Female meiotic drive shapes the distribution of rare inversion polymorphisms in Drosophila melanogaster [0.03%]
雌性配子驱动形成了黑腹果蝇罕见倒位多态性的分布格局
Spencer A Koury
Spencer A Koury
In all species, new chromosomal inversions are constantly being formed by spontaneous rearrangement and then stochastically eliminated from natural populations. In Drosophila, when new chromosomal inversions overlap with a preexisting inver...
Setting the stage for development: the maternal-to-zygotic transition in Drosophila [0.03%]
设定舞台以迎接发育：果蝇卵母细胞到合子阶段的转换
Melissa M Harrison,Audrey J Marsh,Christine A Rushlow
Melissa M Harrison
The zygote has a daunting task ahead of itself; it must develop from a single cell (fertilized egg) into a fully functioning adult with a multitude of different cell types. In the beginning, the zygote has help from its mother, in the form ...
Evaluation of population structure inferred by principal component analysis or the admixture model [0.03%]
主成分分析法和混杂模型在评价人群结构中的应用评估
Jan van Waaij,Song Li,Genís Garcia-Erill et al.
Jan van Waaij et al.
Principal component analysis (PCA) is commonly used in genetics to infer and visualize population structure and admixture between populations. PCA is often interpreted in a way similar to inferred admixture proportions, where it is assumed ...