Improvement of polygenic modeling of blood pressure traits using lifestyle information in the UK Biobank [0.03%]
利用英国生物样本库中的生活方式信息改进多基因血压性状建模
Francesco Tiezzi,Khushi Goda,Fabio Morgante
Francesco Tiezzi
Complex traits are determined by the effects of multiple genetic variants, multiple environmental factors, and potentially their interaction. Predicting complex trait phenotypes from genotypes is a fundamental task in quantitative genetics ...
Expanding biobank pharmacogenomics through machine learning calls of structural variation [0.03%]
基于机器学习的结构变异呼叫在生物库药物基因组学中的应用
Brett Vanderwerff,Amy L Pasternak,Lars G Fritsche et al.
Brett Vanderwerff et al.
Biobanks linking genetic data with clinical health records provide exciting opportunities for pharmacogenomic (PGx) research on genetic variation and drug response. Designed as central and multi-use resources, biobanks can facilitate divers...
Genome-wide analysis reveals genes mediating resistance to paraquat neurodegeneration in Drosophila [0.03%]
全基因组分析揭示了介导果蝇百草枯神经退行性病变抗性的基因
Stefanny Villalobos-Cantor,Alicia Arreola-Bustos,Ian Martin
Stefanny Villalobos-Cantor
Parkinson's disease (PD) is thought to develop through a complex interplay of genetic and environmental factors. Epidemiological studies have linked exposure to certain pesticides such as paraquat with elevated PD risk, although how a perso...
Parameters that influence bipartite reporter system expression in Caenorhabditis elegans [0.03%]
影响秀丽隐杆线虫二元报告系统表达的因素
Emma Knoebel,Anna Brinck,Michael L Nonet
Emma Knoebel
The development of bipartite reporter systems in Caenorhabditis elegans has lagged by more than a decade behind its adoption in Drosophila, the other invertebrate model commonly used to dissect biological mechanisms. Here, we characterize m...
Breakpoint-chiasma interference in pericentric inversion heterokaryotypes [0.03%]
臂内倒位杂合子的断点-交换干扰现象研究
Øystein Kapperud
Øystein Kapperud
Heterozygous inversion breakpoints inhibit the formation of chiasmata in their vicinity, and it has been suggested that they do so through the same mechanism that also causes interference between chiasmata. In this paper, I therefore extend...
Analysis of lifespan across Diversity Outbred mouse studies identifies multiple longevity-associated loci [0.03%]
基于多样性杂交小鼠品系的长寿位点分析
Martin N Mullis,Kevin M Wright,Anil Raj et al.
Martin N Mullis et al.
Lifespan is an integrative phenotype whose genetic architecture is likely to highlight multiple processes with high impact on health and aging. Here, we conducted a genetic mega-analysis of longevity in Diversity Outbred (DO) mice that incl...
Potassium-selective channelrhodopsins can exert hyper- or depolarizing effects in excitable cells of Caenorhabditis elegans, depending on experimental conditions [0.03%]
钾选择性通道视紫红质可在不同的实验条件下，通过作用于秀丽隐杆线虫的兴奋细胞来发挥去极化或超极化的效应
Christiane Ruse,Jana Liewald,Marius Seidenthal et al.
Christiane Ruse et al.
Among the most frequent applications of optogenetic tools are those for depolarization of excitable cells such as neurons and muscles. Equally important are inhibitory tools that act through cellular hyperpolarization, which often rely on c...
Joshua M Park,Daniel F Pinski,Susan L Forsburg
Joshua M Park
Whole genome duplication, or polyploidy, has been implicated in driving genome instability and tumorigenesis. Recent studies suggest that polyploidy in tumors promotes cancer genome evolution, progression, and chemoresistance resulting in w...
rDNA copy number variation affects yeast fitness in response to different environments [0.03%]
端粒拷贝数变异影响酵母适应不同环境的耐受性
Kevin Thornton,Elizabeth X Kwan,Kerry Bubb et al.
Kevin Thornton et al.
Ribosomal DNA (rDNA) in eukaryotes is maintained in hundreds of copies with rDNA copy number varying greatly among individuals within a species. In the budding yeast Saccharomyces cerevisiae, the rDNA copy number across wild isolates ranges...