Incorporating experimental mortality improves statistical inference of crossover patterning along meiotic chromosomes [0.03%]
计入实验性死亡可改善统计推断在减数分裂染色体上的交叉排序
Spencer Koury,Melika Ghasemi Shiran,Eva Hammonds et al.
Spencer Koury et al.
Classic recombination experiments designed to test genetic and environmental treatments do not directly measure chromosomal exchange, instead rates and distribution of crossing-over in F1 meiocytes are inferred from genetic markers in F2 ad...
An Expectation and Maximization Algorithm for Multivariate Genome-wide Association Studies (EMmvGWAS) [0.03%]
多元全基因组关联研究的期望最大化算法（EMmvGWAS）
Chin-Sheng Teng,Xuesong Wang,Cheng Liu et al.
Chin-Sheng Teng et al.
Genome-wide association studies (GWAS) commonly focus on one quantitative trait at a time, even when multiple traits are collected. However, joint analysis of multiple traits can increase the power to detect genetic associations by leveragi...
Amyloid precursor protein ortholog Appl acts with Vnd during mushroom body axon growth in Drosophila [0.03%]
淀粉样前体蛋白同源物APPL与VND在果蝇蘑菇身体轴突生长过程中的作用关系研究
Claire Marquilly,Germain U Busto,Laure Pasquer et al.
Claire Marquilly et al.
The amyloid precursor protein (APP) is associated with Alzheimer's disease. Appl is the single Drosophila APP ortholog and is expressed in all neurons throughout development. Appl was previously shown to cell-autonomously modulate axon outg...
Population structure can reduce clonal interference when sexual reproduction and dispersal are synchronized [0.03%]
有性生殖和传播同步可降低种群结构中的系谱干扰作用
Qihan Liu,Daniel B Weissman
Qihan Liu
In populations with limited recombination, clonal interference among beneficial mutations limits the maximum rate of adaptation. Spatial structure slows the spread of beneficial alleles; in purely asexual populations, this increases the amo...
Optimizing strain selection for association studies under hard cost constraints [0.03%]
低成本约束下家系样本选择的优化方法研究
Christoph D Rau,Patrick H Bradley
Christoph D Rau
Quantitative genetics methods linking genotype to phenotype are powerful tools in model organisms and non-human populations, allowing researchers to apply well-controlled perturbations to commercially-available strain collections. However, ...
Methods to Detect Selection History in a Population under Ongoing Directional Selection [0.03%]
在持续性定向选择下检测种群选择史的方法
Anne C M Jansen,Mario P L Calus,Yvonne C J Wientjes
Anne C M Jansen
The aim of animal breeding is to select the genetically best animals to improve the performance of future generations for a specific breeding goal. Knowledge of the (indirect) selection history of new traits is valuable before adding it to ...
Genomic Islands in Wolbachia Prophages Drive Amplification and Diversification of Cytoplasmic Incompatibility Genes in Culex pipiens [0.03%]
蚊子细胞质不相容性的基因岛和基因增殖及多样化
Julien Amoros,Alice Namias,Théo Durand et al.
Julien Amoros et al.
Wolbachia are maternally inherited endosymbiotic bacteria widespread among arthropods. They manipulate their host reproduction to enhance their prevalence in host populations. The most common manipulation is cytoplasmic incompatibility (CI)...
Scm3 interacts with the N-terminal tail of Cse4 to regulate kinetochore assembly in budding yeast [0.03%]
SCM3通过与芽殖酵母CSE4的N端相互作用调控胞质遗传支架装配
Prakhar Agarwal,Anushka Alekar,Shubhomita Mallick et al.
Prakhar Agarwal et al.
The kinetochore is a multiprotein complex formed at the centromeres and is essential for the faithful chromosome segregation. In most of the organisms the kinetochore is assembled on a specialized centromeric nucleosome where histone H3 is ...
Shared anti-biofilm targets of biofilm regulators Wor3 and Bcr1 in Candida albicans [0.03%]
白色念珠菌生物被膜调节因子Wor3和Bcr1的共享抗生物被膜作用靶点
Katharina Goerlich,Norma V Solis,Scott G Filler et al.
Katharina Goerlich et al.
Candida albicans is an opportunistic fungal pathogen and a component of the human microbiome. C. albicans virulence traits include biofilm production, which is governed by a large transcriptional network. Mutations of some biofilm regulator...
Bursts of reproduction can create genetic structure in frequently recombining bacterial populations [0.03%]
繁殖爆发可以为频繁重组的细菌种群创造遗传结构
C J Jiang,Daniel B Weissman
C J Jiang
In many bacterial species, strong genetic structure is present, where individuals are clustered into genetically distinct groupings within the species. However, high rates of homologous recombination have also been observed in many of these...