Orthologs of the Caenorhabditis elegans heterochronic genes have divergent functions in Caenorhabditis briggsae [0.03%]
拟南芥异时基因的正交基因在布鲁格沙虫中的功能分化
Maria Ivanova,Eric G Moss
Maria Ivanova
The heterochronic genes of Caenorhabditis elegans comprise the best-studied pathway controlling the timing of tissue and organ formation in an animal. To begin to understand the evolution of this pathway and the significance of the relation...
High levels of intra-strain structural variation in Drosophila simulans X pericentric heterochromatin [0.03%]
拟步甲模拟种属内异染色体结构变异水平较高
Cécile Courret,Amanda M Larracuente
Cécile Courret
Large genome structural variations can impact genome regulation and integrity. Repeat-rich regions like pericentric heterochromatin are vulnerable to structural rearrangements although we know little about how often these rearrangements occ...
Revised fission yeast gene and allele nomenclature guidelines for machine readability [0.03%]
机器可读性模式下的裂殖酵母基因和等位基因命名规范修订版
Manuel Lera-Ramírez,Jürg Bähler,Juan Mata et al.
Manuel Lera-Ramírez et al.
Standardized nomenclature for genes, gene products, and isoforms is crucial to prevent ambiguity and enable clear communication of scientific data, facilitating efficient biocuration and data sharing. Standardized genotype nomenclature, whi...
Cut homeodomain transcription factor is a novel regulator of growth and morphogenesis of cortex glia niche around neural cells [0.03%]
切割型同源域转录因子是调控神经细胞周围皮层胶质库生长及形态发生的新型因子
Vaishali Yadav,Ramkrishna Mishra,Papri Das et al.
Vaishali Yadav et al.
Cortex glia in Drosophila central nervous system form a niche around neural cells for necessary signals to establish cross talk with their surroundings. These cells grow and expand their thin processes around neural cell bodies. Although es...
Spenito-dependent metabolic sexual dimorphism intrinsic to fat storage cells [0.03%]
雄性偏倚的脂肪细胞固有代谢性别二态性
Arely V Diaz,Daniel Stephenson,Travis Nemkov et al.
Arely V Diaz et al.
Metabolism in males and females is distinct. Differences are usually linked to sexual reproduction, with circulating signals (e.g. hormones) playing major roles. In contrast, sex differences prior to sexual maturity and intrinsic to individ...
Aspergillus SUMOylation mutants exhibit chromosome segregation defects including chromatin bridges [0.03%]
曲霉SUMO化突变体表现出染色体分离缺陷包括染色质桥形成缺陷
Jun Zhang,Rongde Qiu,Baronger D Bieger et al.
Jun Zhang et al.
Functions of protein SUMOylation remain incompletely understood in different cell types. Via forward genetics, here we identified ubaBQ247*, a loss-of-function mutation in a SUMO activation enzyme UbaB in the filamentous fungus Aspergillus ...
Scaling the discrete-time Wright-Fisher model to biobank-scale datasets [0.03%]
离散时间Wright-Fisher模型在生物库规模数据集上的扩展
Jeffrey P Spence,Tony Zeng,Hakhamanesh Mostafavi et al.
Jeffrey P Spence et al.
The discrete-time Wright-Fisher (DTWF) model and its diffusion limit are central to population genetics. These models can describe the forward-in-time evolution of allele frequencies in a population resulting from genetic drift, mutation, a...
Identification of CryAB as a target of NUAK kinase activity in Drosophila muscle tissue [0.03%]
鉴定CryAB为果蝇肌肉组织中NUAK激酶活性的目标
Ziwei Zhao,David Brooks,Yungui Guo et al.
Ziwei Zhao et al.
Phosphorylation reactions performed by protein kinases are one of the most studied post-translational modifications within cells. Much is understood about conserved residues within protein kinase domains that perform catalysis of the phosph...
Hedgehog signaling guides migration of primordial germ cells to the Drosophila somatic gonad [0.03%]
刺猬信号引导果蝇体细胞生殖腺中原始生殖细胞的迁移
Girish Deshpande,Chris Ng,Nicholas Jourjine et al.
Girish Deshpande et al.
In addition to inducing nonautonomous specification of cell fate in both Drosophila and vertebrates, the Hedgehog pathway guides cell migration in a variety of different tissues. Although its role in axon guidance in the vertebrate nervous ...
Reverse genetic screening during L1 arrest reveals a role of the diacylglycerol kinase 1 gene dgk-1 and sphingolipid metabolism genes in sleep regulation [0.03%]
利用L1停滞期进行反向遗传学筛选揭示了糖脂激酶1基因dgk-1和鞘脂代谢基因在睡眠调节中的作用
Anastasios Koutsoumparis,Inka Busack,Chung-Kuan Chen et al.
Anastasios Koutsoumparis et al.
Sleep is a fundamental state of behavioral quiescence and physiological restoration. Sleep is controlled by environmental conditions, indicating a complex regulation of sleep by multiple processes. Our knowledge of the genes and mechanisms ...