Isolated loss of the AUTS2 long isoform, brain-wide or targeted to Calbindin-lineage cells, generates a specific suite of brain, behavioral, and molecular pathologies [0.03%]
AUTS2长转录本脑区特异丢失产生特定的神经、行为和分子缺陷
Yunshu Song,Christopher H Seward,Chih-Ying Chen et al.
Yunshu Song et al.
Rearrangements within the AUTS2 region are associated with a rare syndromic disorder with intellectual disability, developmental delay, and behavioral abnormalities as core features. In addition, smaller regional variants are linked to wide...
Mutator transposon insertions within maize genes often provide a novel outward reading promoter [0.03%]
穆塔突变子转座插入构建了新的外读起始子并位于玉米基因内
Erika L Ellison,Peng Zhou,Peter Hermanson et al.
Erika L Ellison et al.
The highly active family of Mutator (Mu) DNA transposons has been widely used for forward and reverse genetics in maize. There are examples of Mu-suppressible alleles that result in conditional phenotypic effects based on the activity of Mu...
Variation in transcription regulator expression underlies differences in white-opaque switching between the SC5314 reference strain and the majority of Candida albicans clinical isolates [0.03%]
白色-透明切换在参考菌株SC5314和大多数临床分离株中存在差异的原因是转录调节因子表达不同
Matthew B Lohse,Naomi Ziv,Alexander D Johnson
Matthew B Lohse
Candida albicans, a normal member of the human microbiome and an opportunistic fungal pathogen, undergoes several morphological transitions. One of these transitions is white-opaque switching, where C. albicans alternates between 2 stable c...
Adhesion and Polarity protein distribution-regulates hexagon dominated plasma membrane organization in Drosophila blastoderm embryos [0.03%]
斑马蝇胚胎合子阶段上皮细胞六边形化由黏附和极性蛋白分布调控
Bipasha Dey,Debasmita Mitra,Tirthasree Das et al.
Bipasha Dey et al.
Epithelial cells contain polarity complexes on the lateral membrane and are organized in a hexagon-dominated polygonal array. The mechanisms regulating the organization of polygonal architecture in metazoan embryogenesis are not completely ...
Frequent, infinitesimal bottlenecks maximize the rate of microbial adaptation [0.03%]
频繁且微小的瓶颈效应最大化微生物适应速率
Oscar Delaney,Andrew D Letten,Jan Engelstädter
Oscar Delaney
Serial passaging is a fundamental technique in experimental evolution. The choice of bottleneck severity and frequency poses a dilemma: longer growth periods allow beneficial mutants to arise and grow over more generations, but simultaneous...
Expression and function of Caenorhabditis elegans UNCP-18, a paralog of the SM protein UNC-18 [0.03%]
秀丽隐杆线虫sm蛋白unc-18的直系同源基因uncp-18的表达及功能研究
Marion Boeglin,Eduardo Leyva-Díaz,Oliver Hobert
Marion Boeglin
Sec1/Munc18 (SM) proteins are important regulators of SNARE complex assembly during exocytosis throughout all major animal tissue types. However, expression of a founding member of the SM family, UNC-18, is mostly restricted to the nervous ...
Correction to: Somatic mutations inferred from RNA-seq data highlight the contribution of replication timing to mutation rate variation in a model plant [0.03%]
Correction to：基于RNA测序数据推断的体细胞突变表明复制时间对模型植物中突变率变异的贡献
Published Erratum
Genetics. 2023 Oct 4;225(2):iyad166. DOI:10.1093/genetics/iyad166 2023
Daniel Schmitz,Zhiwei Li,Valeria Lo Faro et al.
Daniel Schmitz et al.
Structural variations, including copy number variations (CNVs), affect around 20 million bases in the human genome and are common causes of rare conditions. CNVs are rarely investigated in complex disease research because most CNVs are not ...
Dissection of the role of a Src homology 3 domain in the evolution of binding preference of paralogous proteins [0.03%]
通过解剖Src同源3结构域分析旁系同源蛋白结合偏好的进化作用
Pascale Lemieux,David Bradley,Alexandre K Dubé et al.
Pascale Lemieux et al.
Protein-protein interactions (PPIs) drive many cellular processes. Some interactions are directed by Src homology 3 (SH3) domains that bind proline-rich motifs on other proteins. The evolution of the binding specificity of SH3 domains is no...