Crossover shortage in potato is caused by StMSH4 mutant alleles and leads to either highly uniform unreduced pollen or sterility [0.03%]
土豆杂交障碍由StMSH4突变等位基因导致且产生高度均匀的二倍体花粉或不育现象
Corentin R Clot,Dennis Klein,Joey Koopman et al.
Corentin R Clot et al.
The balanced segregation of homologous chromosomes during meiosis is essential for fertility and is mediated by crossovers (COs). A strong reduction of CO number leads to the unpairing of homologous chromosomes after the withdrawal of the s...
Stephanie E Mohr,Ah-Ram Kim,Yanhui Hu et al.
Stephanie E Mohr et al.
Genes that have been identified in the genome but remain uncharacterized with regards to function offer an opportunity to uncover novel biological information. Novelty is exciting but can also be a barrier. If nothing is known, how does one...
Eftychia Kyriacou,Patrick Heun
Eftychia Kyriacou
The fruit fly Drosophila melanogaster serves as a powerful model organism for advancing our understanding of biological processes, not just by studying its similarities with other organisms including ourselves but also by investigating its ...
E2F1, DIAP1, and the presence of a homologous chromosome promote while JNK inhibits radiation-induced loss of heterozygosity in Drosophila melanogaster [0.03%]
E2F1、DIAP1以及同源染色体的存在能够促进而JNK抑制果蝇的放射诱导异ozygosity（LOH）现象
Jeremy Brown,Tin Tin Su
Jeremy Brown
Loss of heterozygosity (LOH) can occur when a heterozygous mutant cell loses the remaining wild-type allele to become a homozygous mutant. LOH can have physiological consequences if, for example, the affected gene encodes a tumor suppressor...
Diversification of small RNA pathways underlies germline RNA interference incompetence in wild Caenorhabditis elegans strains [0.03%]
野生型秀丽隐杆线虫菌株中生殖系RNA干扰功能不全源自小分子RNA通路的多样化
Han Ting Chou,Francisco Valencia,Jacqueline C Alexander et al.
Han Ting Chou et al.
The discovery that experimental delivery of dsRNA can induce gene silencing at target genes revolutionized genetics research, by both uncovering essential biological processes and creating new tools for developmental geneticists. However, t...
Critical view on oligo(dT)-based RNA-seq: bias arising, modeling, and mitigating [0.03%]
寡dT建库RNA测序偏差产生的原因、建模及缓解措施批判性分析
Qiang Su,Jun Wang,Kang Kang et al.
Qiang Su et al.
The precise biological interpretation of oligo(dT)-based RNA sequencing (RNA-seq) datasets, particularly in single-cell RNA-seq (scRNA-seq), is invaluable for understanding complex biological systems. However, the presence of biases can lea...
Jun Liu,John Isaac Murray
Jun Liu
The studies of cell fate and lineage specification are fundamental to our understanding of the development of multicellular organisms. Caenorhabditis elegans has been one of the premiere systems for studying cell fate specification mechanis...
Mutations in abnormal spindle disrupt temporal transcription factor expression and trigger immune responses in the Drosophila brain [0.03%]
异常纺锤体突变会扰乱果蝇大脑中的时间转录因子表达并触发免疫反应
Maria C Mannino,Mercedes Bartels Cassidy,Steven Florez et al.
Maria C Mannino et al.
The coordination of cellular behaviors during neurodevelopment is critical for determining the form, function, and size of the central nervous system (CNS). Mutations in the vertebrate Abnormal Spindle-Like, Microcephaly Associated (ASPM) g...
Pervasive G × E interactions shape adaptive trajectories and the exploration of the phenotypic space in artificial selection experiments [0.03%]
泛在的G×E互作影响人工选择实验中的适应轨迹和表型空间的探索
Arnaud Desbiez-Piat,Adrienne Ressayre,Elodie Marchadier et al.
Arnaud Desbiez-Piat et al.
Quantitative genetics models have shown that long-term selection responses depend on initial variance and mutational influx. Understanding limits of selection requires quantifying the role of mutational variance. However, correlative respon...
The impact of paramutations on the invasion dynamics of transposable elements [0.03%]
顺式作用元件的参数突变对转座子入侵动力学的影响
Almorò Scarpa,Robert Kofler
Almorò Scarpa
According to the prevailing view, the trap model, the activity of invading transposable elements (TEs) is greatly reduced when a TE copy jumps into a piRNA cluster, which triggers the emergence of piRNAs that silence the TE. One crucial com...