Finishing the egg [0.03%]
画蛇添足
Celeste Berg,Matthew Sieber,Jianjun Sun
Celeste Berg
Gamete development is a fundamental process that is highly conserved from early eukaryotes to mammals. As germ cells develop, they must coordinate a dynamic series of cellular processes that support growth, cell specification, patterning, t...
Lipophorin receptors genetically modulate neurodegeneration caused by reduction of Psn expression in the aging Drosophila brain [0.03%]
遗传调节脂蛋白受体可缓解由衰老果蝇大脑Psn表达减少引起的神经退行性病变
Jongkyun Kang,Chen Zhang,Yuhao Wang et al.
Jongkyun Kang et al.
Mutations in the Presenilin (PSEN) genes are the most common cause of early-onset familial Alzheimer's disease (FAD). Studies in cell culture, in vitro biochemical systems, and knockin mice showed that PSEN mutations are loss-of-function mu...
Catalytic activity of the Bin3/MePCE methyltransferase domain is dispensable for 7SK snRNP function in Drosophila melanogaster [0.03%]
二𫫇英Bin3/MePCE甲基转移酶结构域对果蝇7SK小核仁体RNA颗粒功能是不需要的
Ryan J Palumbo,Yuan Yang,Juli Feigon et al.
Ryan J Palumbo et al.
Methylphosphate Capping Enzyme (MePCE) monomethylates the gamma phosphate at the 5' end of the 7SK noncoding RNA, a modification thought to protect 7SK from degradation. 7SK serves as a scaffold for assembly of a snRNP complex that inhibits...
Fourth Chromosome Resource Project: a comprehensive resource for genetic analysis in Drosophila that includes humanized stocks [0.03%]
第四染色体资源项目：一个全面的遗传分析果蝇资源库，包括人类化系品系
Michael J Stinchfield,Brandon P Weasner,Bonnie M Weasner et al.
Michael J Stinchfield et al.
The fourth chromosome is the final frontier for genetic analysis in Drosophila. Small, heterochromatic, and devoid of recombination the fourth has long been ignored. Nevertheless, its long arm contains 79 protein-coding genes. The Fourth Ch...
Kim M Summers
Kim M Summers
The fibrillinopathies represent a group of diseases in which the 10-12 nm extracellular microfibrils are disrupted by genetic variants in one of the genes encoding fibrillin molecules, large glycoproteins of the extracellular matrix. The be...
Mutations in yeast Pcf11, a conserved protein essential for mRNA 3' end processing and transcription termination, elicit the Environmental Stress Response [0.03%]
酵母Pcf11突变体的基因研究_Pcf11是mRNA加工和转录终止所必需的保守蛋白，其突变可以激发环境压力反应
Joel H Graber,Derick Hoskinson,Huiyun Liu et al.
Joel H Graber et al.
The Pcf11 protein is an essential subunit of the large complex that cleaves and polyadenylates eukaryotic mRNA precursor. It has also been functionally linked to gene-looping, termination of RNA Polymerase II (Pol II) transcripts, and mRNA ...
Has recombination changed during the recent evolution of the guppy Y chromosome? [0.03%]
近年来纺锤鱼Y染色体的重组发生了变化吗？
Deborah Charlesworth,Suo Qiu,Roberta Bergero et al.
Deborah Charlesworth et al.
Genome sequencing and genetic mapping of molecular markers have demonstrated nearly complete Y-linkage across much of the guppy (Poecilia reticulata) XY chromosome pair. Predominant Y-linkage of factors controlling visible male-specific col...
Germline mitotic quiescence and cell death are induced in Caenorhabditis elegans by exposure to pathogenic Pseudomonas aeruginosa [0.03%]
巴氏芽孢杆菌能使线虫Caenorhabditis elegans的胚系细胞静止并导致其死亡
Daniel P Bollen,Kirthi C Reddy,Laura I Lascarez-Lagunas et al.
Daniel P Bollen et al.
The impact of exposure to microbial pathogens on animal reproductive capacity and germline physiology is not well understood. The nematode Caenorhabditis elegans is a bacterivore that encounters pathogenic microbes in its natural environmen...
A role for β-1,6- and β-1,3-glucans in kinetochore function in Saccharomyces cerevisiae [0.03%]
β-1,6-和β-1,3-糖原在酿酒酵母着丝粒功能中的作用
Rucha Kshirsagar,Arno Munhoven,Tra My Tran Nguyen et al.
Rucha Kshirsagar et al.
Chromosome segregation is crucial for the faithful inheritance of DNA to the daughter cells after DNA replication. For this, the kinetochore, a megadalton protein complex, assembles on centromeric chromatin containing the histone H3 variant...
The SWI/SNF nucleosome remodeler constrains enhancer activity during Drosophila wing development [0.03%]
SWI/SNF核小体重塑复合物通过限制果蝇翅发育过程中的增强子活性来发挥制约作用
Matthew J Niederhuber,Mary Leatham-Jensen,Daniel J McKay
Matthew J Niederhuber
Chromatin remodeling is central to the dynamic changes in gene expression that drive cell fate determination. During development, the sets of enhancers that are accessible for use change globally as cells transition between stages. While tr...