Recombination hotspots in Neurospora crassa controlled by idiomorphic sequences and meiotic silencing [0.03%]
神经孢子菌中的重组热点受同源序列和减数分裂抑制的控制
Patricia Jane Yeadon,Frederick J Bowring,David Edward Arnold Catcheside
Patricia Jane Yeadon
Genes regulating recombination in specific chromosomal intervals of Neurospora crassa were described in the 1960s, but the mechanism is still unknown. For each of the rec-1, rec-2, and rec-3 genes, a single copy of the putative dominant all...
Takuya Akiyama,Laurel A Raftery,Kristi A Wharton
Takuya Akiyama
In the mid-1960s, bone morphogenetic proteins (BMPs) were first identified in the extracts of bone to have the remarkable ability to induce heterotopic bone. When the Drosophila gene decapentaplegic (dpp) was first identified to share seque...
A pair of RNA binding proteins inhibit ion transporter expression to maintain lifespan [0.03%]
一对RNA结合蛋白通过抑制离子运输蛋白的表达来维持寿命
Rebekah Napier-Jameson,Olivia Marx,Adam Norris
Rebekah Napier-Jameson
Regulation of lifespan by transcription factors has been well established. More recently, a role for RNA binding proteins (RBPs) in regulating lifespan has also emerged. In both cases, a major challenge is to determine which regulatory targ...
Using encrypted genotypes and phenotypes for collaborative genomic analyses to maintain data confidentiality [0.03%]
利用加密基因型和表型进行协作组学分析以维护数据保密性
Tianjing Zhao,Fangyi Wang,Richard Mott et al.
Tianjing Zhao et al.
To adhere to and capitalize on the benefits of the FAIR (findable, accessible, interoperable, and reusable) principles in agricultural genome-to-phenome studies, it is crucial to address privacy and intellectual property issues that prevent...
Molecular identification of a peroxidase gene controlling body size in the entomopathogenic nematode Steinernema hermaphroditum [0.03%]
Steinernema hermaphroditum 拟杆状菌虫类线虫中控制体型大小的过氧化物酶基因的分子鉴定
Hillel T Schwartz,Chieh-Hsiang Tan,Jackeline Peraza et al.
Hillel T Schwartz et al.
The entomopathogenic nematode Steinernema hermaphroditum was recently rediscovered and is being developed as a genetically tractable experimental system for the study of previously unexplored biology, including parasitism of its insect host...
Bradysia (Sciara) coprophila larvae up-regulate DNA repair pathways and down-regulate developmental regulators in response to ionizing radiation [0.03%]
Bradysia（Sciara）coprophila幼虫对电离辐射的响应：DNA修复通路上调和发育调节因子下调
John M Urban,Jack R Bateman,Kodie R Garza et al.
John M Urban et al.
The level of resistance to radiation and the developmental and molecular responses can vary between species, and even between developmental stages of one species. For flies (order: Diptera), prior studies concluded that the fungus gnat Brad...
A cosmopolitan inversion facilitates seasonal adaptation in overwintering Drosophila [0.03%]
一种世界主义的逆转促进了果蝇越冬时的季节性适应
Joaquin C B Nunez,Benedict A Lenhart,Alyssa Bangerter et al.
Joaquin C B Nunez et al.
Fluctuations in the strength and direction of natural selection through time are a ubiquitous feature of life on Earth. One evolutionary outcome of such fluctuations is adaptive tracking, wherein populations rapidly adapt from standing gene...
Meta-Analysis
Genetics. 2024 Feb 7;226(2):iyad207. DOI:10.1093/genetics/iyad207 2024
rvTWAS: identifying gene-trait association using sequences by utilizing transcriptome-directed feature selection [0.03%]
利用转录组导向特征选择识别基因性状关联的序列方法
Jingni He,Qing Li,Qingrun Zhang
Jingni He
Toward the identification of genetic basis of complex traits, transcriptome-wide association study (TWAS) is successful in integrating transcriptome data. However, TWAS is only applicable for common variants, excluding rare variants in exom...
Comparison of transcriptome-wide N6-methyladenosine profiles from healthy trio families reveals regulator-mediated methylation alterations [0.03%]
基于健康三人家庭的转录组范围内的N6-甲基腺苷图谱比较揭示了调控介导的甲基化改变
Yini Li,Hang Liu,Chuan He et al.
Yini Li et al.
The N6-methyladenosine (m6A) modification is a highly conserved RNA modification found in eukaryotic messenger RNAs (mRNAs). It plays a vital role in regulating various biological processes. Dysregulation of m6A modifications has been linke...
rec-1 loss of function increases recombination in the central gene clusters at the expense of autosomal pairing centers [0.03%]
REC-1功能丧失增加中心基因簇的重组而以常染色体配对中心为代价
Tom Parée,Luke Noble,João Ferreira Gonçalves et al.
Tom Parée et al.
Meiotic control of crossover (CO) number and position is critical for homologous chromosome segregation and organismal fertility, recombination of parental genotypes, and the generation of novel genetic combinations. We here characterize th...