Arzu Öztürk-Çolak,Steven J Marygold,Giulia Antonazzo et al.
Arzu Öztürk-Çolak et al.
FlyBase (flybase.org) is a model organism database and knowledge base about Drosophila melanogaster, commonly known as the fruit fly. Researchers from around the world rely on the genetic, genomic, and functional information available in Fl...
Effects of parental age and polymer composition on short tandem repeat de novo mutation rates [0.03%]
父母年龄和聚合物组成对短串联重复序列新生突变率的影响
Michael E Goldberg,Michelle D Noyes,Evan E Eichler et al.
Michael E Goldberg et al.
Short tandem repeats (STRs) are hotspots of genomic variability in the human germline because of their high mutation rates, which have long been attributed largely to polymerase slippage during DNA replication. This model suggests that STR ...
Distinct genomic contexts predict gene presence-absence variation in different pathotypes of Magnaporthe oryzae [0.03%]
不同的Magnaporthe oryzae病原类型中基因存在与否变异的不同的基因组背景预测
Pierre M Joubert,Ksenia V Krasileva
Pierre M Joubert
Fungi use the accessory gene content of their pangenomes to adapt to their environments. While gene presence-absence variation contributes to shaping accessory gene reservoirs, the genomic contexts that shape these events remain unclear. Si...
A missense SNP in the tumor suppressor SETD2 reduces H3K36me3 and mitotic spindle integrity in Drosophila [0.03%]
肿瘤抑制因子SETD2中的一个错义突变可以降低果蝇中的H3K36me3和有丝分裂纺锤体的完整性
Jovan S Brockett,Tad Manalo,Hala Zein-Sabatto et al.
Jovan S Brockett et al.
Mutations in SETD2 are among the most prevalent drivers of renal cell carcinoma (RCC). We identified a novel single nucleotide polymorphism (SNP) in SETD2, E902Q, within a subset of RCC patients, which manifests as both an inherited or tumo...
Maternal mitochondrial function affects paternal mitochondrial inheritance in Drosophila [0.03%]
母系的线粒体功能影响果蝇中的父系线粒体遗传
Jinguo Cao,Yuying Luo,Yonghe Chen et al.
Jinguo Cao et al.
The maternal inheritance of mitochondria is a widely accepted paradigm, and mechanisms that prevent paternal mitochondria transmission to offspring during spermatogenesis and postfertilization have been described. Although certain species d...
Counting the genetic ancestors from source populations in members of an admixed population [0.03%]
混合人群中从原始群体遗传祖先的数量统计
Lily Agranat-Tamir,Jazlyn A Mooney,Noah A Rosenberg
Lily Agranat-Tamir
In a genetically admixed population, admixed individuals possess genealogical and genetic ancestry from multiple source groups. Under a mechanistic model of admixture, we study the number of distinct ancestors from the source populations th...
Calcineurin contributes to RNAi-mediated transgene silencing and small interfering RNA production in the human fungal pathogen Cryptococcus neoformans [0.03%]
钙调神经磷酸酶有助于人真菌病原体新生隐球酵母菌中小干扰RNA的产生及RNAi介导的转基因沉默作用
Vikas Yadav,Riya Mohan,Sheng Sun et al.
Vikas Yadav et al.
Adaptation to external environmental challenges at the cellular level requires rapid responses and involves relay of information to the nucleus to drive key gene expression changes through downstream transcription factors. Here, we describe...
Gene loss and cis-regulatory novelty shaped core histone gene evolution in the apiculate yeast Hanseniaspora uvarum [0.03%]
基因丢失和顺式调控新颖性塑造了点绍酵母汉森氏葡萄孢的核心组蛋白基因进化
Max A B Haase,Jacob L Steenwyk,Jef D Boeke
Max A B Haase
Core histone genes display a remarkable diversity of cis-regulatory mechanisms despite their protein sequence conservation. However, the dynamics and significance of this regulatory turnover are not well understood. Here, we describe the ev...
Echinobase: a resource to support the echinoderm research community [0.03%]
Echinobase：支持棘皮动物研究社区的资源
Cheryl A Telmer,Kamran Karimi,Macie M Chess et al.
Cheryl A Telmer et al.
Echinobase (www.echinobase.org) is a model organism knowledgebase serving as a resource for the community that studies echinoderms, a phylum of marine invertebrates that includes sea urchins and sea stars. Echinoderms have been important ex...
Shared evolutionary processes shape landscapes of genomic variation in the great apes [0.03%]
相似的进化过程塑造了大猿基因组变异的景观
Murillo F Rodrigues,Andrew D Kern,Peter L Ralph
Murillo F Rodrigues
For at least the past 5 decades, population genetics, as a field, has worked to describe the precise balance of forces that shape patterns of variation in genomes. The problem is challenging because modeling the interactions between evoluti...