Interpreting generative adversarial networks to infer natural selection from genetic data [0.03%]
利用生成对抗网络解析以推断自然选择中的遗传数据
Rebecca Riley,Iain Mathieson,Sara Mathieson
Rebecca Riley
Understanding natural selection and other forms of non-neutrality is a major focus for the use of machine learning in population genetics. Existing methods rely on computationally intensive simulated training data. Unlike efficient neutral ...
Characterization of adaptation mechanisms in sorghum using a multireference back-cross nested association mapping design and envirotyping [0.03%]
利用多参考回交嵌套关联作图设计和环境表型特征对高粱的适应性机制进行鉴定
Vincent Garin,Chiaka Diallo,Mohamed Lamine Tékété et al.
Vincent Garin et al.
Identifying the genetic factors impacting the adaptation of crops to environmental conditions is of key interest for conservation and selection purposes. It can be achieved using population genomics, and evolutionary or quantitative genetic...
PomBase: a Global Core Biodata Resource-growth, collaboration, and sustainability [0.03%]
PomBase：全球核心生物数据资源-增长、合作和可持续性
Kim M Rutherford,Manuel Lera-Ramírez,Valerie Wood
Kim M Rutherford
PomBase (https://www.pombase.org), the model organism database (MOD) for fission yeast, was recently awarded Global Core Biodata Resource (GCBR) status by the Global Biodata Coalition (GBC; https://globalbiodata.org/) after a rigorous selec...
High-throughput genetic manipulation of multicellular organisms using a machine-vision guided embryonic microinjection robot [0.03%]
用于胚胎显微注射机器人的高通量遗传操作多细胞生物的机器视觉指导系统
Andrew D Alegria,Amey S Joshi,Jorge Blanco Mendana et al.
Andrew D Alegria et al.
Microinjection is a technique used for transgenesis, mutagenesis, cell labeling, cryopreservation, and in vitro fertilization in multiple single and multicellular organisms. Microinjection requires specialized skills and involves rate-limit...
Enrichment of hard sweeps on the X chromosome compared to autosomes in six Drosophila species [0.03%]
六种果蝇中X染色体上的硬选择清除比常染色体更丰富
Mariana Harris,Bernard Y Kim,Nandita Garud
Mariana Harris
The X chromosome, being hemizygous in males, is exposed one-third of the time increasing the visibility of new mutations to natural selection, potentially leading to different evolutionary dynamics than autosomes. Recently, we found an enri...
Histone variant H2A.Z and linker histone H1 influence chromosome condensation in Saccharomyces cerevisiae [0.03%]
组蛋白变异H2A.Z和连接组蛋白H1影响酿酒酵母中的染色体浓缩
Anna M Rogers,Nola R Neri,Lorencia Chigweshe et al.
Anna M Rogers et al.
Chromosome condensation is essential for the fidelity of chromosome segregation during mitosis and meiosis. Condensation is associated both with local changes in nucleosome structure and larger-scale alterations in chromosome topology media...
To be or not to be: orb, the fusome and oocyte specification in Drosophila [0.03%]
存在还是不存在：卵母细胞的命运决定与orb和fusome的作用机制研究
Justinn Barr,Rocky Diegmiller,Megan M Colonnetta et al.
Justinn Barr et al.
In the fruit fly Drosophila melanogaster, two cells in a cyst of 16 interconnected cells have the potential to become the oocyte, but only one of these will assume an oocyte fate as the cysts transition through regions 2a and 2b of the germ...
An expression-directed linear mixed model discovering low-effect genetic variants [0.03%]
表达式导向的线性混合模型发现低效遗传变异
Qing Li,Jiayi Bian,Yanzhao Qian et al.
Qing Li et al.
Detecting genetic variants with low-effect sizes using a moderate sample size is difficult, hindering downstream efforts to learn pathology and estimating heritability. In this work, by utilizing informative weights learned from training ge...
Role of the San1 ubiquitin ligase in the heat stress-induced degradation of nonnative Nup1 in the nuclear pore complex [0.03%]
San1泛素连接酶在热应激诱导核孔复合物中非天然Nup1降解中的作用
Takanari Ikeda,Kenji Yamazaki,Fumihiko Okumura et al.
Takanari Ikeda et al.
The nuclear pore complex (NPC) mediates the selective exchange of macromolecules between the nucleus and the cytoplasm. Neurodegenerative diseases such as amyotrophic lateral sclerosis are characterized by mislocalization of nucleoporins (N...
Premature endocycling of Drosophila follicle cells causes pleiotropic defects in oogenesis [0.03%]
果蝇卵细胞的过早内循环导致卵母细胞生成的多效缺陷
Hunter C Herriage,Brian R Calvi
Hunter C Herriage
Endocycling cells grow and repeatedly duplicate their genome without dividing. Cells switch from mitotic cycles to endocycles in response to developmental signals during the growth of specific tissues in a wide range of organisms. The purpo...