Quantitative proteomic analysis reveals unique Hsp90 cycle-dependent client interactions [0.03%]
定量蛋白组学分析揭示独特的Hsp90周期依赖性客户相互作用
Erick I Rios,Davi Gonçalves,Kevin A Morano et al.
Erick I Rios et al.
Hsp90 is an abundant and essential molecular chaperone that mediates the folding and activation of client proteins in a nucleotide-dependent cycle. Hsp90 inhibition directly or indirectly impacts the function of 10-15% of all proteins due t...
UNC-16 interacts with LRK-1 and WDFY-3 to regulate the termination of axon growth [0.03%]
UNC-16与LRK-1和WDFY-3相互作用调节轴突生长停止
Cody J Drozd,Tamjid A Chowdhury,Christopher C Quinn
Cody J Drozd
In humans, MAPK8IP3 (also known as JIP3) is a neurodevelopmental disorder-associated gene. In Caenorhabditis elegans, the UNC-16 ortholog of the MAPK8IP3 protein can regulate the termination of axon growth. However, its role in this process...
Enhanced pan-genomic resources at the maize genetics and genomics database [0.03%]
基于玉米遗传和基因组数据库的泛基因组资源优化
Ethalinda K Cannon,John L Portwood nd,Rita K Hayford et al.
Ethalinda K Cannon et al.
Pan-genomes, encompassing the entirety of genetic sequences found in a collection of genomes within a clade, are more useful than single reference genomes for studying species diversity. This is especially true for a species like Zea mays, ...
A Recql5 mutant facilitates complex CRISPR/Cas9-mediated chromosomal engineering in mouse zygotes [0.03%]
一种Recql5突变体促进了小鼠受精卵中复杂CRISPR/Cas9基因组编辑
Satoru Iwata,Miki Nagahara,Risako Ido et al.
Satoru Iwata et al.
Complex chromosomal rearrangements (CCRs) are often observed in clinical samples from patients with cancer and congenital diseases but are difficult to induce experimentally. Here, we report the first success in establishing animal models f...
The impact of differential transposition activities of autonomous and nonautonomous hAT transposable elements on genome architecture and gene expression in Caenorhabditis inopinata [0.03%]
自主和非自主hAT转座子的差异转座活性对Caenorhabditis inopinata基因组结构和基因表达的影响
Ryuhei Hatanaka,Katsunori Tamagawa,Nami Haruta et al.
Ryuhei Hatanaka et al.
Transposable elements are DNA sequences capable of moving within genomes and significantly influence genomic evolution. The nematode Caenorhabditis inopinata exhibits a much higher transposable element copy number than its sister species, C...
WormBase 2024: status and transitioning to Alliance infrastructure [0.03%]
WormBase 2024：现状及过渡到联盟基础设施
Paul W Sternberg,Kimberly Van Auken,Qinghua Wang et al.
Paul W Sternberg et al.
WormBase has been the major repository and knowledgebase of information about the genome and genetics of Caenorhabditis elegans and other nematodes of experimental interest for over 2 decades. We have 3 goals: to keep current with the fast-...
Julien Y Dutheil
Julien Y Dutheil
The rate at which recombination events occur in a population is an indicator of its effective population size and the organism's reproduction mode. It determines the extent of linkage disequilibrium along the genome and, thereby, the effica...
Quantitative genetic analysis of attractiveness of yeast products to Drosophila [0.03%]
吸引力的定量遗传分析：酵母产品对果蝇的吸引力
Weiru Yan,Yishen Li,Edward J Louis et al.
Weiru Yan et al.
An attractive perfume is a complex mixture of compounds, some of which may be unpleasant on their own. This is also true for the volatile combinations from yeast fermentation products in vineyards and orchards when assessed by Drosophila. H...
Alliance of Genome Resources Consortium
Alliance of Genome Resources Consortium
The Alliance of Genome Resources (Alliance) is an extensible coalition of knowledgebases focused on the genetics and genomics of intensively studied model organisms. The Alliance is organized as individual knowledge centers with strong conn...
Sex peptide receptor is not required for refractoriness to remating or induction of egg laying in Aedes aegypti [0.03%]
塞密肽受体不是埃及伊蚊交配后不交配和产卵诱导所必需的
I Alexandra Amaro,Margot P Wohl,Sylvie Pitcher et al.
I Alexandra Amaro et al.
Across diverse insect taxa, the behavior and physiology of females dramatically changes after mating-processes largely triggered by the transfer of seminal proteins from their mates. In the vinegar fly Drosophila melanogaster, the seminal p...