Illuminating the Cryptococcus neoformans species complex: unveiling intracellular structures with fluorescent-protein-based markers [0.03%]
揭示Cryptococcus neoformans物种复合体：利用荧光蛋白标记物揭露细胞内结构
Ran Shi,Xiaorong Lin
Ran Shi
Cryptococcus neoformans is a fungal pathogen of the top critical priority recognized by the World Health Organization. This clinically important fungus also serves as a eukaryotic model organism. A variety of resources have been generated t...
C. elegans Hedgehog-related proteins are tissue- and substructure-specific components of the cuticle and pre-cuticle [0.03%]
秀丽隐杆线虫Hh相关蛋白是表皮及其亚结构的组成成分
Nicholas D Serra,Chelsea B Darwin,Meera V Sundaram
Nicholas D Serra
In C. elegans, expanded families of divergent Hedgehog-related and Patched-related proteins promote numerous processes ranging from epithelial and sense organ development to pathogen responses to cuticle shedding during the molt cycle. The ...
TWISP: a transgenic worm for interrogating signal propagation in Caenorhabditis elegans [0.03%]
TWISP：一种用于解码秀丽隐杆线虫信号传导的转基因线虫
Anuj Kumar Sharma,Francesco Randi,Sandeep Kumar et al.
Anuj Kumar Sharma et al.
Genetically encoded optical indicators and actuators of neural activity allow for all-optical investigations of signaling in the nervous system. But commonly used indicators, actuators, and expression strategies are poorly suited for system...
Deleterious mutation/epimutation-selection balance with and without inbreeding: a population (epi)genetics model [0.03%]
近交条件下有害基因突变和表观遗传变异的平衡：一个群体（表观）遗传模型
Gregory Chernomas,Cortland K Griswold
Gregory Chernomas
Epigenetics in the form of DNA methylation and other processes is an established property of genotypes and a focus of empirical research. Yet, there remain fundamental gaps in the evolutionary theory of epigenetics. To support a comprehensi...
UV damage induces production of mitochondrial DNA fragments with specific length profiles [0.03%]
紫外线损伤诱导具有特定长度谱系的线粒体DNA片段产生
Gus Waneka,Joseph Stewart,John R Anderson et al.
Gus Waneka et al.
UV light is a potent mutagen that induces bulky DNA damage in the form of cyclobutane pyrimidine dimers (CPDs). Photodamage and other bulky lesions occurring in nuclear genomes can be repaired through nucleotide excision repair (NER), where...
Allele frequency dynamics under sex-biased demography and sex-specific inheritance in a pedigreed jay population [0.03%]
一种喜鹊种群中性别偏向的人口统计学和遗传方式下的等位基因频率动力学
Rose M H Driscoll,Felix E G Beaudry,Elissa J Cosgrove et al.
Rose M H Driscoll et al.
Sex-biased demography, including sex-biased survival or migration, can alter allele frequency changes across the genome. In particular, we can expect different patterns of genetic variation on autosomes and sex chromosomes due to sex-specif...
siRNA that participates in Drosophila dosage compensation is produced by many 1.688X and 359 bp repeats [0.03%]
参与果蝇剂量补偿的siRNA由许多1.688X和359bp重复序列产生
Sudeshna Biswas,Katherine Gurdziel,Victoria H Meller
Sudeshna Biswas
Organisms with differentiated sex chromosomes must accommodate unequal gene dosage in males and females. Male fruit flies increase X-linked gene expression to compensate for hemizygosity of their single X chromosome. Full compensation requi...
Notch signaling without the APH-2/nicastrin subunit of gamma secretase in Caenorhabditis elegans germline stem cells [0.03%]
APH-2/尼卡斯特林蛋白缺失情况下 notch 信号途径在秀丽隐杆线虫生殖干细胞中的作用机制研究
David M Brinkley,Karen C Smith,Emma C Fink et al.
David M Brinkley et al.
The final step in Notch signaling activation is the transmembrane cleavage of Notch receptor by γ secretase. Thus far, genetic and biochemical evidence indicates that four subunits are essential for γ secretase activity in vivo: presenili...
Translational control of MPS1 links protein synthesis with the initiation of cell division and spindle pole body duplication in Saccharomyces cerevisiae [0.03%]
MPS1的翻译控制将蛋白质合成与细胞分裂的发生和芽殖酵母(Saccharomyces cerevisiae)杆状体复制联系起来
Heidi M Blank,Annabel Alonso,Amy S Fabritius et al.
Heidi M Blank et al.
Protein synthesis underpins cell growth and controls when cells commit to a new round of cell division at a point in late G1 of the cell cycle called Start. Passage through Start also coincides with the duplication of the microtubule-organi...
Carl Mackintosh,Michael F Scott,Max Reuter et al.
Carl Mackintosh et al.
Inversions have been proposed to facilitate local adaptation, by linking together locally coadapted alleles at different loci. Prior work addressing this question theoretically has considered the spread of inversions in "continent-island" s...