Post-transcriptional regulation of the T-box gene midline via the 3'UTR in Drosophila is complex and cell and tissue-dependent [0.03%]
果蝇midline基因的3'UTR通过后转录水平复杂而细胞及组织特异性的调控T-盒基因
Kalpana Makhijani,Jordan Mar,Ivana Gaziova et al.
Kalpana Makhijani et al.
The T-box proteins have a 180-230 amino acid DNA-binding domain, first reported in the Brachyury (T) protein. It is highly conserved among metazoans. They regulate a multitude of cellular functions in development and disease. Here, we repor...
Selection leads to false inferences of introgression using popular methods [0.03%]
选择会导致使用流行方法进行杂交渗透的虚假推断
Megan L Smith,Matthew W Hahn
Megan L Smith
Detecting introgression between closely related populations or species is a fundamental objective in evolutionary biology. Existing methods for detecting migration and inferring migration rates from population genetic data often assume a ne...
FLN-2 functions in parallel to linker of nucleoskeleton and cytoskeleton complexes and CDC-42/actin pathways during P-cell nuclear migration through constricted spaces in Caenorhabditis elegans [0.03%]
FLN-2与线粒体相关核周骨架相互作用介导C. elegans P细胞核迁移中的受压空间效应
Linda Ma,Jonathan Kuhn,Yu-Tai Chang et al.
Linda Ma et al.
Nuclear migration through narrow constrictions is important for development, metastasis, and proinflammatory responses. Studies performed in tissue culture cells have implicated linker of nucleoskeleton and cytoskeleton (LINC) complexes, mi...
Insights into ribosomal DNA dominance and magnification through characterization of isogenic deletion alleles [0.03%]
通过同基因删除等位基因的表征来深入了解核糖体DNA的优势和放大作用
Selina M Kindelay,Keith A Maggert
Selina M Kindelay
The major loci for the large primary ribosomal RNA (rRNA) genes (35S rRNAs) exist as hundreds to thousands of tandem repeats in all organisms and dozens to hundreds in Drosophila. The highly repetitive nature of the ribosomal DNA (rDNA) mak...
Knockdown of NeuroD2 leads to seizure-like behavior, brain neuronal hyperactivity and a leaky blood-brain barrier in a Xenopus laevis tadpole model of DEE75 [0.03%]
神经元抑制导致类似癫痫的行为、大脑神经元过度活跃和DEE75非洲爪蟾蝌蚪模型中的漏血脑屏障
Sulagna Banerjee,Paul Szyszka,Caroline W Beck
Sulagna Banerjee
Developmental and Epileptic Encephalopathies (DEE) are a genetically diverse group of severe, early onset seizure disorders. DEE are normally identified clinically in the first six months of life by the presence of frequent, difficult to co...
Maxwell G Heiman,Hannes E Bülow
Maxwell G Heiman
Since the days of Ramón y Cajal, the vast diversity of neuronal and particularly dendrite morphology has been used to catalog neurons into different classes. Dendrite morphology varies greatly and reflects the different functions performed...
How group structure impacts the numbers at risk for coronary artery disease: polygenic risk scores and nongenetic risk factors in the UK Biobank cohort [0.03%]
英国生物样本库队列中冠状动脉疾病易感人数的聚类结构特征及影响因素：多基因风险评分和非遗传性危险因素的影响分析
Jinbo Zhao,Adrian O&#x;Hagan,Michael Salter-Townshend
Jinbo Zhao
The UK Biobank (UKB) is a large cohort study that recruited over 500,000 British participants aged 40-69 in 2006-2010 at 22 assessment centers from across the United Kingdom. Self-reported health outcomes and hospital admission data are 2 t...
Sequence reliance of the Drosophila context-dependent transcription factor CLAMP [0.03%]
CLAMP的序列依赖性及其在果蝇中的作用机制研究
Lauren J Hodkinson,Julia Gross,Casey A Schmidt et al.
Lauren J Hodkinson et al.
Despite binding similar cis elements in multiple locations, a single transcription factor (TF) often performs context-dependent functions at different loci. How factors integrate cis sequence and genomic context is still poorly understood a...
Analysis of meiotic recombination in Drosophila simulans shows no evidence of an interchromosomal effect [0.03%]
模式果蝇拟无眼果蝇(Drosophila simulans)减数重组分析未发现染色体间的效应
Bowen Man,Elizabeth Kim,Alekhya Vadlakonda et al.
Bowen Man et al.
Chromosome inversions are of unique importance in the evolution of genomes and species because when heterozygous with a standard arrangement chromosome, they suppress meiotic crossovers within the inversion. In Drosophila species, heterozyg...
Estimating scale-specific and localized spatial patterns in allele frequency [0.03%]
估算等位基因频率的尺度特异性和局部空间模式
Jesse R Lasky,Margarita Takou,Diana Gamba et al.
Jesse R Lasky et al.
Characterizing spatial patterns in allele frequencies is fundamental to evolutionary biology because these patterns contain evidence of underlying processes. However, the spatial scales at which gene flow, changing selection, and drift act ...