Paul Battlay,Sam Yeaman,Kathryn A Hodgins
Paul Battlay
Observations of genetically repeated evolution (repeatability) in complex organisms are incongruent with the Fisher-Orr model, which implies that repeated use of the same gene should be rare when mutations are pleiotropic (i.e., affect mult...
The Caenorhabditis elegans cuticle and precuticle: a model for studying dynamic apical extracellular matrices in vivo [0.03%]
秀丽隐杆线虫的角质层和原角质层：体内研究动态顶侧细胞外基质的模型
Meera V Sundaram,Nathalie Pujol
Meera V Sundaram
Apical extracellular matrices (aECMs) coat the exposed surfaces of animal bodies to shape tissues, influence social interactions, and protect against pathogens and other environmental challenges. In the nematode Caenorhabditis elegans, coll...
The Drosophila TNF Eiger promotes Myc super-competition independent of canonical JNK signaling [0.03%]
果蝇TNF Eiger通过非经典的JNK信号促进Myc超竞争性生长
Albana L Kodra,Aditi Sharma Singh,Claire de la Cova et al.
Albana L Kodra et al.
Numerous factors have been implicated in the cell-cell interactions that lead to elimination of cells via cell competition, a context-dependent process of cell selection in somatic tissues that is based on comparisons of cellular fitness. H...
Mck1-mediated proteolysis of CENP-A prevents mislocalization of CENP-A for chromosomal stability in Saccharomyces cerevisiae [0.03%]
McK1介导的CSE2降解阻止了芽殖酵母染色体稳定性的CSE2异位分布现象
Tianyi Zhang,Wei-Chun Au,Kentaro Ohkuni et al.
Tianyi Zhang et al.
Centromeric localization of evolutionarily conserved CENP-A (Cse4 in Saccharomyces cerevisiae) is essential for chromosomal stability. Mislocalization of overexpressed CENP-A to non-centromeric regions contributes to chromosomal instability...
An acidic loop in the FHA domain of the yeast meiosis-specific kinase Mek1 interacts with a specific motif in a subset of Mek1 substrates [0.03%]
酿酒酵母同源重组激酶Mek1的FHA结构域中的一个酸性环与Mek1部分底物上的特定基序相互作用
Qixuan Weng,Lihong Wan,Geburah C Straker et al.
Qixuan Weng et al.
The meiosis-specific kinase Mek1 regulates key steps in meiotic recombination in the budding yeast, Saccharomyces cerevisiae. MEK1 limits resection at double strand break (DSB) ends and is required for preferential strand invasion into homo...
Radio-miRs: a comprehensive view of radioresistance-related microRNAs [0.03%]
无线电ミRs：与放射耐受性相关的全面的微小核糖核酸观点
Abraham Pedroza-Torres,Sandra L Romero-Córdoba,Sarita Montaño et al.
Abraham Pedroza-Torres et al.
Radiotherapy is a key treatment option for a wide variety of human tumors, employed either alone or alongside with other therapeutic interventions. Radiotherapy uses high-energy particles to destroy tumor cells, blocking their ability to di...
The cytidine deaminase APOBEC3C has unique sequence and genome feature preferences [0.03%]
胞苷脱氨酶APOBEC3C具有独特的序列和基因组特征偏好性
Grant W Brown
Grant W Brown
APOBEC proteins are cytidine deaminases that restrict the replication of viruses and transposable elements. Several members of the APOBEC3 family, APOBEC3A, APOBEC3B, and APOBEC3H-I, can access the nucleus and cause what is thought to be in...
Tetraploid interspecific hybrids between Asian and African rice species restore fertility depending on killer-protector loci for hybrid sterility [0.03%]
亚洲稻和非洲稻的四倍体种间杂交通过异配生殖系统的相互作用恢复育性
Daichi Kuniyoshi,Megumi Ishihara,Koichi Yamamori et al.
Daichi Kuniyoshi et al.
Interspecific F1 hybrids between Asian (Oryza sativa) and African rice (Oryza glaberrima) exhibit severe sterility caused by the accumulation of hybrid sterility genes/loci at 15 or more loci. The mechanisms underlying the hybrid sterility ...
SNP profile for quantitative trait nucleotide in populations with small effective size and its impact on mapping and genomic predictions [0.03%]
小有效群体大小下数量性状位点的单倍型特征及其对定位和全基因组预测的影响
Ivan Pocrnic,Daniela Lourenco,Ignacy Misztal
Ivan Pocrnic
Increasing SNP density by incorporating sequence information only marginally increases prediction accuracies of breeding values in livestock. To find out why, we used statistical models and simulations to investigate the shape of distributi...
The chromatin-associated 53BP1 ortholog, HSR-9, regulates recombinational repair and X chromosome segregation in the Caenorhabditis elegans germ line [0.03%]
染色质相关53BP1同源物HSR-9调节秀丽隐杆线虫生殖系中的重组修复和X染色体分离
Qianyan Li,Sara Hariri,Aashna Calidas et al.
Qianyan Li et al.
53BP1 plays a crucial role in regulating DNA damage repair pathway choice and checkpoint signaling in somatic cells; however, its role in meiosis has remained enigmatic. In this study, we demonstrate that the Caenorhabditis elegans ortholog...