Conditional nmy-1 and nmy-2 alleles establish that nonmuscle myosins are required for late Caenorhabditis elegans embryonic elongation [0.03%]
条件性nmy-1和nmy-2等位基因表明非肌肉肌球蛋白是秀丽杆线虫胚胎晚期延长所必需的
Kelly Molnar,Shashi Kumar Suman,Jeanne Eichelbrenner et al.
Kelly Molnar et al.
The elongation of Caenorhabditis elegans embryos allows examination of mechanical interactions between adjacent tissues. Muscle contractions during late elongation induce the remodeling of epidermal circumferential actin filaments through m...
Origin and maintenance of large ribosomal RNA gene repeat size in mammals [0.03%]
哺乳动物大型核糖体RNA基因重复大小的起源和维持
Emma Macdonald,Annabel Whibley,Paul D Waters et al.
Emma Macdonald et al.
The genes encoding ribosomal RNA are highly conserved across life and in almost all eukaryotes are present in large tandem repeat arrays called the rDNA. rDNA repeat unit size is conserved across most eukaryotes but has expanded dramaticall...
Redesigning the Drosophila histone gene cluster: an improved genetic platform for spatiotemporal manipulation of histone function [0.03%]
重新设计果蝇组蛋白基因簇：用于时空操控组蛋白功能的改进遗传平台
Aaron T Crain,Markus Nevil,Mary P Leatham-Jensen et al.
Aaron T Crain et al.
Mutating replication-dependent (RD) histone genes is an important tool for understanding chromatin-based epigenetic regulation. Deploying this tool in metazoans is particularly challenging because RD histones in these organisms are typicall...
PACS-1 variant protein is aberrantly localized in Caenorhabditis elegans model of PACS1/PACS2 syndromes [0.03%]
帕金森病相关蛋白1变异型蛋白质在解码氏秀丽隐杆线虫模型中定位异常
Dana T Byrd,Ziyuan Christina Han,Christopher A Piggott et al.
Dana T Byrd et al.
PACS (phosphofurin acidic cluster sorting) proteins are known for their roles in sorting cargo proteins to organelles and can physically interact with WD40 repeat-containing protein WDR37. PACS1, PACS2, and WDR37 variants are associated wit...
Overlapping coactivator function is required for transcriptional activation by the Candida glabrata Pdr1 transcription factor [0.03%]
重叠的共激活功能是念珠菌glabrataPdr1转录因子转录激活所必需的
Thomas P Conway,Lucia Simonicova,W Scott Moye-Rowley
Thomas P Conway
Azole resistance in the pathogenic yeast Candida glabrata is a serious clinical complication and increasing in frequency. The majority of resistant organisms have been found to contain a substitution mutation in the Zn2Cys6 zinc cluster-con...
ADR-2 regulates fertility and oocyte fate in Caenorhabditis elegans [0.03%]
C. elegans ADR-2调控生殖和卵子命运
Emily A Erdmann,Melanie Forbes,Margaret Becker et al.
Emily A Erdmann et al.
RNA-binding proteins (RBPs) play essential roles in coordinating germline gene expression and development in all organisms. Here, we report that loss of ADR-2, a member of the adenosine deaminase acting on RNA family of RBPs and the sole ad...
RABR-1, an atypical Rab-related GTPase, cell-nonautonomously restricts somatosensory dendrite branching [0.03%]
非典型型Rab相关GTP酶RABR-1限制感觉神经元树突分支范围
Christopher J Salazar,Carlos A Diaz-Balzac,Yu Wang et al.
Christopher J Salazar et al.
Neurons are highly polarized cells with dendrites and axons. Dendrites, which receive sensory information or input from other neurons, often display elaborately branched morphologies. While mechanisms that promote dendrite branching have be...
A general and efficient representation of ancestral recombination graphs [0.03%]
一种祖先生化图的一般性和高效性表示方法
Yan Wong,Anastasia Ignatieva,Jere Koskela et al.
Yan Wong et al.
As a result of recombination, adjacent nucleotides can have different paths of genetic inheritance and therefore the genealogical trees for a sample of DNA sequences vary along the genome. The structure capturing the details of these intric...
Testing times: disentangling admixture histories in recent and complex demographies using ancient DNA [0.03%]
测试时代：使用古DNA解开近期复杂人口中的混合历史
Matthew P Williams,Pavel Flegontov,Robert Maier et al.
Matthew P Williams et al.
Our knowledge of human evolutionary history has been greatly advanced by paleogenomics. Since the 2020s, the study of ancient DNA has increasingly focused on reconstructing the recent past. However, the accuracy of paleogenomic methods in r...
Chk2 homolog Mek1 limits exonuclease 1-dependent DNA end resection during meiotic recombination in Saccharomyces cerevisiae [0.03%]
酵母有性生殖重组过程中Mek1通过限制Exo1依赖的DNA末端切除作用来限制同源重组的作用大小
Jennifer T Krystosek,Douglas K Bishop
Jennifer T Krystosek
The conserved Rad2/XPG family 5'-3' exonuclease, exonuclease 1 (Exo1), plays many roles in DNA metabolism including during resolution of DNA double-strand breaks via homologous recombination. Prior studies provided evidence that the end res...