The geometry of admixture in population genetics: the blessing of dimensionality [0.03%]
群体遗传学中的杂交几何结构：维度带来的福音
José-Angel Oteo,Gonzalo Oteo-García
José-Angel Oteo
We present a geometry-based interpretation of the f-statistics framework, commonly used in population genetics to estimate phylogenetic relationships from genomic data. The focus is on the determination of the mixing coefficients in populat...
Fdo1, Fkh1, Fkh2, and the Swi6-Mbp1 MBF complex regulate Mcd1 levels to impact eco1 rad61 cell growth in Saccharomyces cerevisiae [0.03%]
FDO1，FKH1，FKH2以及SWI6-MBP1 MBF复合体通过调节MCD1的水平来影响eco1 rad61细胞在酿酒酵母中的生长
Gurvir Singh,Robert V Skibbens
Gurvir Singh
Cohesins promote proper chromosome segregation, gene transcription, genomic architecture, DNA condensation, and DNA damage repair. Mutations in either cohesin subunits or regulatory genes can give rise to severe developmental abnormalities ...
Tools and methods for cell ablation and cell inhibition in Caenorhabditis elegans [0.03%]
秀丽杆线虫中的细胞消融和抑制的工具与方法
Dennis Rentsch,Amelie Bergs,Jiajie Shao et al.
Dennis Rentsch et al.
To understand the function of cells such as neurons within an organism, it can be instrumental to inhibit cellular function, or to remove the cell (type) from the organism, and thus to observe the consequences on organismic and/or circuit f...
Comparative analysis of new mScarlet-based red fluorescent tags in Caenorhabditis elegans [0.03%]
基于新mScarlet的钙视网膜蛋白红色荧光标记物在秀丽隐杆线虫中的比较分析
Wen Xi Cao,Daniel M Merritt,Karinna Pe et al.
Wen Xi Cao et al.
One problem that has hampered the use of red fluorescent proteins in the fast-developing nematode Caenorhabditis elegans has been the substantial time delay in maturation of several generations of red fluorophores. The recently described mS...
Comparative Study
Genetics. 2024 Oct 7;228(2):iyae126. DOI:10.1093/genetics/iyae126 2024
Tdh3 and Rom2 are functional modulators of a conserved condensate-resident RNA-binding protein, Scd6, in Saccharomyces cerevisiae [0.03%]
酿酒酵母中的Tdh3和Rom2是保守的凝聚体定殖RNA结合蛋白Scd6的功能调节因子
Chitra Togra,Riya Dhage,Purusharth I Rajyaguru
Chitra Togra
Arginine-glycine-glycine motif proteins play a crucial role in determining mRNA fate. Suppressor of clathrin deficiency 6 (Scd6) is a conserved arginine-glycine-glycine motif containing ribonucleoprotein (RNP) condensate-resident, translati...
Jun Liu,Elsa Bonnard,Monika Scholz
Jun Liu
Improved genetically encoded calcium indicators (GECIs) are essential for capturing intracellular dynamics of both muscle and neurons. A novel set of GECIs with ultrafast kinetics and high sensitivity was recently reported by Zhang et al. (...
Candida albicans PPR proteins are required for the expression of respiratory Complex I subunits [0.03%]
芽生菌PPR蛋白是呼吸链Complex I亚基表达的必要条件
Joanna Maria Wenda,Katarzyna Drzewicka,Patrycja Mulica et al.
Joanna Maria Wenda et al.
Pentatricopeptide repeat (PPR) proteins bind RNA and are present in mitochondria and chloroplasts of Eukaryota. In fungi, they are responsible for controlling mitochondrial genome expression, mainly on the posttranscriptional level. Candida...
Poly(U) polymerase activity in Caenorhabditis elegans regulates abundance and tailing of sRNA and mRNA [0.03%]
秀丽隐杆线虫中的多聚U聚合酶活性调控sRNA和mRNA的丰度及多聚尾添加现象
Leanne H Kelley,Ian V Caldas,Matthew T Sullenberger et al.
Leanne H Kelley et al.
Terminal nucleotidyltransferases add nucleotides to the 3' end of RNA to modify their stability and function. In Caenorhabditis elegans, the terminal uridyltransferases/poly(U) polymerases PUP-1 (aka CID-1, CDE-1), PUP-2, and PUP-3 affect g...
Gene expression and splicing QTL analysis of blood cells in African American participants from the Jackson Heart Study [0.03%]
杰克逊心脏研究中非洲裔美国人血细胞的基因表达和剪接位点QTL分析
Jia Wen,Quan Sun,Le Huang et al.
Jia Wen et al.
Most gene expression and alternative splicing quantitative trait loci (eQTL/sQTL) studies have been biased toward European ancestry individuals. Here, we performed eQTL and sQTL analyses using TOPMed whole-genome sequencing-derived genotype...