Asymptotically exact fit for linear mixed model in genetic association studies [0.03%]
遗传关联研究中线性混合模型的渐近精确拟合
Yongtao Guan,Daniel Levy
Yongtao Guan
The linear mixed model (LMM) has become a standard in genetic association studies to account for population stratification and relatedness in the samples to reduce false positives. Much recent progresses in LMM focused on approximate comput...
Jackson Bladen,Hyuck-Jin Nam,Nitin Phadnis
Jackson Bladen
Hybrid male sterility is one of the fastest evolving intrinsic reproductive barriers between recently isolated populations. A leading explanation for the evolution of hybrid male sterility involves genomic conflicts with meiotic drivers in ...
In vivo dissection of the mouse tyrosine catabolic pathway with CRISPR-Cas9 identifies modifier genes affecting hereditary tyrosinemia type 1 [0.03%]
CRISPR-Cas9在体内解析小鼠酪氨酸分解途径并鉴定遗传性高血酪氨酸症Ⅰ型的修饰基因
Jean-François Rivest,Sophie Carter,Claudia Goupil et al.
Jean-François Rivest et al.
Hereditary tyrosinemia type 1 is an autosomal recessive disorder caused by mutations (pathogenic variants) in fumarylacetoacetate hydrolase, an enzyme involved in tyrosine degradation. Its loss results in the accumulation of toxic metabolit...
The genetic architecture of polygenic local adaptation and its role in shaping barriers to gene flow [0.03%]
多基因适应的遗传结构及其在塑造基因流动障碍中的作用
Arthur Zwaenepoel,Himani Sachdeva,Christelle Fraïsse
Arthur Zwaenepoel
We consider how the genetic architecture underlying locally adaptive traits determines the strength of a barrier to gene flow in a mainland-island model. Assuming a general life cycle, we derive an expression for the effective migration rat...
Richard J Poole,Nuria Flames,Luisa Cochella
Richard J Poole
Animals rely on their nervous systems to process sensory inputs, integrate these with internal signals, and produce behavioral outputs. This is enabled by the highly specialized morphologies and functions of neurons. Neuronal cells share mu...
The emerging H3K9me3 chromatin landscape during zebrafish embryogenesis [0.03%]
斑马鱼胚胎发育过程中组蛋白H3K9三甲基化印记的建立与维持机制研究
Katherine L Duval,Ashley R Artis,Mary G Goll
Katherine L Duval
The structural organization of eukaryotic genomes is contingent upon the fractionation of DNA into transcriptionally permissive euchromatin and repressive heterochromatin. However, we have a limited understanding of how these distinct state...
SKN-1 activation during infection of Caenorhabditis elegans requires CDC-48 and endoplasmic reticulum proteostasis [0.03%]
拟南芥感染期间CDC-48和内质网蛋白质稳态需要SKN-1的活化
Carolaing Gabaldón,Ozgur Karakuzu,Danielle A Garsin
Carolaing Gabaldón
During challenge of Caenorhabditis elegans with human bacterial pathogens such as Pseudomonas aeruginosa and Enterococcus faecalis, the elicited host response can be damaging if not properly controlled. The activation of Nrf (nuclear factor...
Behavioral plasticity [0.03%]
行为可塑性
Yun Zhang,Yuichi Iino,William R Schafer
Yun Zhang
Behavioral plasticity allows animals to modulate their behavior based on experience and environmental conditions. Caenorhabditis elegans exhibits experience-dependent changes in its behavioral responses to various modalities of sensory cues...
Matthew Waliman,Ryan L Johnson,Gunalan Natesan et al.
Matthew Waliman et al.
Patterns of lineal descent play a critical role in the development of metazoan embryos. In eutelic organisms that generate a fixed number of somatic cells, invariance in the topology of their cell lineage provides a powerful opportunity to ...
Direct inference of the distribution of fitness effects of spontaneous mutations from recombinant inbred Caenorhabditis elegans mutation accumulation lines [0.03%]
基于重组近交秀丽隐杆线虫突变积累系的自发突变效应分布的直接推断方法
Timothy A Crombie,Moein Rajaei,Ayush Shekhar Saxena et al.
Timothy A Crombie et al.
The distribution of fitness effects of new mutations plays a central role in evolutionary biology. Estimates of the distribution of fitness effect from experimental mutation accumulation lines are compromised by the complete linkage disequi...