My journey with fungi: the beauty and complexity of fungal natural products [0.03%]
我的菌类之旅：菌类天然产物的美丽与复杂性
Nancy P Keller
Nancy P Keller
A dynamic meiotic cohesin complex regulates synaptonemal complex assembly in Drosophila oocytes [0.03%]
动态的减数分裂粘连复合体在果蝇卵细胞中调节联会复合体的组装
Margaret Howland,Helen Nguyen,Daria Mitri et al.
Margaret Howland et al.
There are two meiotic cohesin pathways that regulate synaptonemal complex (SC) assembly in Drosophila melanogaster. We previously proposed that the kleisin C(2)M, which is required for SC assembly, is the only meiosis-specific component of ...
When evolvability meets constraint: reflections on empirical fitness landscapes after Weinreich et al. (2006) [0.03%]
当约束条件限制适应性演化时的反思——兼论Weinreich等(2006)提出的实证适应度地形理论的影响
C Brandon Ogbunugafor
C Brandon Ogbunugafor
In 2006, a manuscript appeared with a provocative title: "Darwinian evolution can follow only very few mutational paths to fitter proteins." Twenty years on, I argue that it was a landmark study, one that promoted a tractable model system-t...
Caenorhabditis tropicalis followed a unique evolutionary path to self-fertility [0.03%]
卡约尼杆形线虫走向自体受精的进化道路独一无二
James Kennedy,Montana Bobinski,Soumi Joseph et al.
James Kennedy et al.
Caenorhabditis nematodes provide three natural experiments in which a male/female species evolved to produce one with males and self-fertile hermaphrodites. Such changes in mating systems are among the most complex and consequential transfo...
Genetic analysis of sensitivity to temperature fluctuations identifies acclimation stress as a novel type of cellular stress in Caenorhabditis elegans [0.03%]
遗传分析鉴定出温度波动敏感性识别出拟南芥中的一个新型细胞压力类型——适应压力型stress
Noah Lilienfeldt,Yifan Tai,Han Sun et al.
Noah Lilienfeldt et al.
All organisms must quickly acclimate to short-term environmental temperature changes to maintain optimal physiology. Temperature excursions far from the optimum lead to heat- or cold-shock responses, which have been extensively studied. We ...
Contrasting Selection on GxE and Main Effect Loci for Soybean Grain Yield [0.03%]
大豆籽粒产量G×E互作效应位点和主效位点的选择格局差异性研究
Mary M Happ,George L Graef,Réka Howard et al.
Mary M Happ et al.
In soybean, breeding programs are designed to select for maximizing yield across environments in the program's region. Genetic loci with positive effects across environments for yield (main effects), will have genetic diversity surrounding ...
The contactin rig-6 transiently promotes GABA neuron remodeling with a sustained impact on male mating behavior in C. elegans [0.03%]
CONTACTIN RIG-6 通过短暂促进秀丽隐杆线虫GABA神经元重塑产生持续的雄性交配行为影响
Sophia M Villiere,Michael P Hart
Sophia M Villiere
Changes in neuronal and synaptic wiring contribute to neurological variations including autism, schizophrenia, and major depressive disorder. Many developmental axon guidance cues, postsynaptic receptors, and other downstream molecular mech...
Recombinant ubbR promoter enables highly efficient tamoxifen-inducible Cre recombination in embryonic and adult zebrafish [0.03%]
一种新型的重组ubbR启动子可高效地在胚胎和成年斑马鱼中诱导他莫昔芬依赖性Cre重组反应
Edita Bakūnaitė,Emilija Gečaitė,Samanta Žemalytė et al.
Edita Bakūnaitė et al.
The ability to inactivate gene function in an adult organism is essential for studies of biological processes such as regeneration and behavior. This is best achieved by engineering an allele that could be conditionally inactivated using dr...
Ecological drivers of coexistence and lethal variant evolution in the t haplotype [0.03%]
t型haplotype共存的生态驱动因素及致死变异进化
Aysegul Birand,Thomas A A Prowse,Phillip Cassey et al.
Aysegul Birand et al.
One of the most extensively studied segregation distorters is the t haplotype in house mice (Mus musculus), which can have transmission rates as high as 99% in heterozygous males. Numerous t-haplotype variants exist that induce male sterili...
The Stellate meiotic drive system of Drosophila melanogaster is active in contemporary populations [0.03%]
果蝇(Drosophila melanogaster)的stellate减数分裂驱动系统在当代种群中活跃
Benjamin K McCormick,Daniel A Barbash,Andrew G Clark
Benjamin K McCormick
Meiotic drivers are selfish elements that bias their own transmission so that they are overrepresented among the functional gametes produced. The selective costs imposed by drivers on their hosts may trigger intragenomic conflict, promoting...