Polygenic strategies for host-specific and general virulence of Botrytis cinerea across diverse eudicot hosts [0.03%]
灰葡萄孢菌在多种真双子叶植物宿主中产生寄主特异性和广谱毒力的多基因策略
Céline Caseys,Daniel J Kliebenstein
Céline Caseys
Diverse qualitative and quantitative genetic architectures can successfully enable fungal virulence and host range. To model the quantitative genetic architecture of a generalist pathogen with an extensive host range, we conducted a genome-...
Matthew W Hahn,Sarthak R Mishra
Matthew W Hahn
Standard methods for estimating the population recombination parameter, ρ, are dependent on sampling individual genotypes and calculating various types of disequilibria. However, recent machine learning (ML) approaches to estimating recomb...
Melanization regulates wound healing by limiting polyploid cell growth in the Drosophila epithelium [0.03%]
血色素沉着通过限制多倍体细胞增殖来调节果蝇上皮组织伤口愈合
Loiselle Gonzalez-Baez,Elizabeth Mortati,Lillie Mitchell et al.
Loiselle Gonzalez-Baez et al.
Wound healing requires a localized response that restricts growth, remodeling, and inflammation to the site of injury. In the fruit fly, Drosophila melanogaster, the epithelium heals puncture wounds through cell growth instead of cell divis...
A unified framework governing the establishment and maintenance of transgenerational epigenetic inheritance [0.03%]
指导跨世代表观遗传继承建立和维持的统一框架
Rachel M Woodhouse,Natalya Frolows,Dhruv S Monteiro et al.
Rachel M Woodhouse et al.
Transgenerational epigenetic inheritance (TEI) is the transfer of non-genetic information between generations. In Caenorhabditis elegans, RNA interference (RNAi) is a conserved process initiated by double-stranded RNA which can induce TEI. ...
The shape of discovery: a journey through genetics, coevolution, and a scientific life [0.03%]
探索的形状：遗传学、协同进化及科学人生之旅
Noah K Whiteman
Noah K Whiteman
Jason Williams
Jason Williams
From its current vantage point, the future of US STEM education may appear bleak. Yet STEM education's strength and importance have never been greater, and evidence points to a bright future. This case can be made by drawing on the United S...
The bur1-107 mutant delays G1/S transition and alleviates hydroxyurea sensitivity in checkpoint-deficient yeast [0.03%]
bur1-107突变体延迟G1/S转换并缓解缺陷酵母中的羟基脲敏感性
Stefany Cristine Rodrigues da Silva,Francisco Meirelles Bastos de Oliveira
Stefany Cristine Rodrigues da Silva
In Saccharomyces cerevisiae, the cyclin-dependent kinase Bur1 is primarily known for its role in promoting transcription elongation, thereby regulating gene expression. In this study, we investigated the genetic interactions between a hypom...
Gertjan Bisschop,Jerome Kelleher,Peter Ralph
Gertjan Bisschop
Ancestral recombination graphs (ARGs) are the focus of much ongoing research interest. Recent progress in inference has made ARG-based approaches feasible across of range of applications, and many new methods using inferred ARGs as input ha...
On the patterns of genetic intra-tumour heterogeneity before and after treatment [0.03%]
治疗前后的遗传性肿瘤异质性的类型研究
Alexander Stein,Benjamin Werner
Alexander Stein
Genetic intra-tumour heterogeneity (gITH) is a universal property of all cancers. It emerges from the interplay of cell division, mutation accumulation and selection with important implications for the evolution of treatment resistance. The...
Aldo Carmona Baez,Patrick J Ciccotto,Emily C Moore et al.
Aldo Carmona Baez et al.
Variation in gastrointestinal morphology is associated with dietary specialization across the animal kingdom. Gut length generally correlates with trophic level, and increased gut length in herbivores is a classic example of adaptation to c...