Neuropeptide signaling network of Caenorhabditis elegans: from structure to behavior [0.03%]
秀丽隐杆线虫神经肽信号网络：从结构到行为
Jan Watteyne,Aleksandra Chudinova,Lidia Ripoll-Sánchez et al.
Jan Watteyne et al.
Neuropeptides are abundant signaling molecules that control neuronal activity and behavior in all animals. Owing in part to its well-defined and compact nervous system, Caenorhabditis elegans has been one of the primary model organisms used...
Genealogical asymmetry under the IM model and a two-taxon test for gene flow [0.03%]
改善IM模型的谱系不对称性及检测双向基因流的两取样群体检验方法
Alexander Mackintosh,Derek Setter
Alexander Mackintosh
Methods for detecting gene flow between populations often rely on asymmetry in the average length of particular genealogical branches, with the ABBA-BABA test being a well known example. Currently, asymmetry-based methods cannot be applied ...
Deep mutational scanning of CYP2C19 in human cells reveals a substrate specificity-abundance tradeoff [0.03%]
人源细胞中的CYP2C19深度突变扫描揭示了底物特异性丰度的权衡关系
Gabriel E Boyle,Katherine A Sitko,Jared G Galloway et al.
Gabriel E Boyle et al.
The cytochrome P450s enzyme family metabolizes ∼80% of small molecule drugs. Variants in cytochrome P450s can substantially alter drug metabolism, leading to improper dosing and severe adverse drug reactions. Due to low sequence conservati...
Gaston I Jofre,Andrius J Dagilis,Victoria E Sepúlveda et al.
Gaston I Jofre et al.
Blastomyces is an emerging primary fungal pathogen that affects patients worldwide. The evolutionary processes that have resulted in the current diversity in the genus remain largely unexplored. We used whole genome sequences from 99 Blasto...
The structural role of Skp1 in the synaptonemal complex is conserved in nematodes [0.03%]
Skp1在蠕虫中维持联会复合体的结构功能具有保守性
Lisa E Kursel,Kaan Goktepe,Ofer Rog
Lisa E Kursel
The synaptonemal complex (SC) is a meiotic interface that assembles between parental chromosomes and is essential for gamete formation. While the dimensions and ultrastructure of the SC are conserved across eukaryotes, its protein component...
An explanation for the sister repulsion phenomenon in Patterson's f-statistics [0.03%]
帕特森f统计量中姐妹排斥现象的解释
Gözde Atağ,Shamam Waldman,Shai Carmi et al.
Gözde Atağ et al.
Patterson's f-statistics are among the most heavily utilized tools for analyzing genome-wide allele frequency data for demographic inference. Beyond studying admixture, f3- and f4-statistics are also used for clustering populations to ident...
The Raf/LIN-45 C-terminal distal tail segment negatively regulates signaling in Caenorhabditis elegans [0.03%]
Raf/LIN-45 C端远尾区段通过负调控信号转导在秀丽隐杆线虫中发挥抑癌作用
Robert A Townley,Kennedy S Stacy,Fatemeh Cheraghi et al.
Robert A Townley et al.
Raf protein kinases act as Ras-GTP sensing components of the ERK signal transduction pathway in animal cells, influencing cell proliferation, differentiation, and survival. In humans, somatic and germline mutations in the genes BRAF and RAF...
Interaction between ESCRT-III proteins and the yeast SERINC homolog Tms1 [0.03%]
酵母SERINC同源物Tms1与ESCRT-III蛋白的相互作用
Ralf Kölling
Ralf Kölling
The endosomal sorting complex required for transport (ESCRT)-III is involved in membrane remodeling and abscission during intraluminal vesicle (ILV) formation at endosomes. Our data now suggest that ESCRT-III function could be connected to ...
Revisiting the role of the spindle assembly checkpoint in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae [0.03%]
revisit染色体分离检测点在酵母基因组不稳定中的作用
Yue Yao,Ziqing Yin,Fernando R Rosas Bringas et al.
Yue Yao et al.
Multiple pathways are known to suppress the formation of gross chromosomal rearrangements (GCRs), which can cause human diseases including cancer. In contrast, much less is known about pathways that promote their formation. The spindle asse...
Role of male gonad-enriched microRNAs in sperm production in Caenorhabditis elegans [0.03%]
男性生殖器官富集的微小RNA在秀丽隐杆线虫精子发生中的作用
Lu Lu,Allison L Abbott
Lu Lu
Germ cell development and gamete production in animals require small RNA pathways. While studies indicate that microRNAs (miRNAs) are necessary for normal sperm production and function, the specific roles for individual miRNAs are largely u...