Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology [0.03%]
分子遗传学与进化生态学中的秀丽杆线虫生活史研究进展
Christian Braendle,Annalise Paaby
Christian Braendle
Life history is defined by traits that reflect key components of fitness, especially those relating to reproduction and survival. Research in life history seeks to unravel the relationships among these traits and understand how life history...
Set2 and H3K36 regulate the Drosophila male X chromosome in a context-specific manner, independent from MSL complex spreading [0.03%]
Drosophila雄性X染色体的调节独立于MSL复合物的扩张效应，组蛋白甲基转移酶Set2和H3K36发挥特异性作用
Harmony R Salzler,Vasudha Vandadi,Julia R Sallean et al.
Harmony R Salzler et al.
Dosage compensation in Drosophila involves upregulating male X-genes two-fold. This process is carried out by the MSL (male-specific lethal) complex, which binds high-affinity sites and spreads to surrounding genes. Current models of MSL sp...
A maternal germline mutator phenotype in a family affected by heritable colorectal cancer [0.03%]
一例家族性遗传结直肠癌母系生殖系突变型表型研究
Candice L Young,Annabel C Beichman,David Mas-Ponte et al.
Candice L Young et al.
Variation in DNA repair genes can increase cancer risk by elevating the rate of oncogenic mutation. Defects in one such gene, MUTYH, are known to elevate the incidence of colorectal cancer in a recessive Mendelian manner. Recent evidence ha...
Takahiro Sakamoto,James R Whiting,Samuel Yeaman
Takahiro Sakamoto
Locally adapted traits can exhibit a wide range of genetic architectures, from pronounced divergence at a few loci to small frequency divergence at many loci. The type of architecture that evolves depends strongly on the migration rate, as ...
A Dominance Hypothesis Argument for Historical Genetic Gains and the Fixation of Heterosis in Octoploid Strawberry [0.03%]
八倍体草莓历史遗传增益及杂种优势固定的一种优势假说解释
Mitchell J Feldmann,Dominique D A Pincot,Danelle K Seymour et al.
Mitchell J Feldmann et al.
Heterosis was the catalyst for the domestication of cultivated strawberry (Fragaria × ananassa), an interspecific hybrid species that originated in the 1700s. The hybrid origin was discovered because the phenotypes of spontaneous hybrids t...
Location of polyadenylation sites within 3' untranslated regions is linked to biological function in yeast [0.03%]
酵母中多腺苷酸化位点的位置与生物功能相关联
Joseph V Geisberg,Zarmik Moqtaderi,Kevin Struhl
Joseph V Geisberg
Expression of a typical yeast gene results in ∼50 3' mRNA isoforms that are distinguished by the locations of poly(A) sites within the 3' untranslated regions (3' UTRs). The location of poly(A) sites with respect to the translational termi...
Zane Johnson,Yun Wang,Benjamin M Sutter et al.
Zane Johnson et al.
In yeast, control of sulfur amino acid metabolism relies upon Met4, a transcription factor that activates the expression of a network of enzymes responsible for the biosynthesis of cysteine and methionine. In times of sulfur abundance, the ...
Sharp decline in male fertility in F2 hybrids of the female-heterogametic silk moth Bombyx [0.03%]
家系二代杂交蚕蛾雄性生育力急剧下降
Kana Matsukawa,Yasuko Kato,Aya Yoshida et al.
Kana Matsukawa et al.
Sexual selection drives rapid evolution of morphological, physiological, and behavioral traits, especially in males, and it may also drive the rapid evolution of hybrid male sterility. Indeed, the faster male theory of speciation was once v...
The distribution of beneficial mutational effects between two sister yeast species poorly explains natural outcomes of vineyard adaptation [0.03%]
两种姊妹酵母物种之间的有益突变效应分布不足以解释葡萄园适应的自然结果
Emery R Longan,Justin C Fay
Emery R Longan
Domesticated strains of Saccharomyces cerevisiae have adapted to resist copper and sulfite, two chemical stressors commonly used in winemaking. S. paradoxus has not adapted to these chemicals despite being consistently present in sympatry w...
Automated multimodal imaging of Caenorhabditis elegans behavior in multi-well plates [0.03%]
全自动多模式成像技术在96孔板中检测秀丽隐杆线虫的行为学
Hongfei Ji,Dian Chen,Christopher Fang-Yen
Hongfei Ji
Assays of behavior in model organisms play an important role in genetic screens, drug testing, and the elucidation of gene-behavior relationships. We have developed an automated, high-throughput imaging and analysis method for assaying beha...