Population size rescaling significantly biases outcomes of forward-in-time population genetic simulations [0.03%]
人口规模的重缩严重偏向前向种群遗传模拟的结果
Amjad Dabi,Daniel R Schrider
Amjad Dabi
Simulations are an essential tool in all areas of population genetic research, used in tasks such as the validation of theoretical analysis and the study of complex evolutionary models. Forward-in-time simulations are especially flexible, a...
A review of multimodal deep learning methods for genomic-enabled prediction in plant breeding [0.03%]
基于组学数据的作物育种多模态深度学习方法研究进展综述
Osval A Montesinos-López,Moises Chavira-Flores,Kiasmiantini et al.
Osval A Montesinos-López et al.
Deep learning methods have been applied when working to enhance the prediction accuracy of traditional statistical methods in the field of plant breeding. Although deep learning seems to be a promising approach for genomic prediction, it ha...
Megavariate Methods Capture Complex Genotype-by-Environment Interactions [0.03%]
mega变量方法捕获复杂的基因型-环境交互作用
Alencar Xavier,Daniel Runcie,David Habier
Alencar Xavier
Genomic prediction models that capture genotype-by-environment interaction are useful for predicting site-specific performance by leveraging information among related individuals and correlated environments, but implementing such models is ...
Leveraging a new data resource to define the response of C. neoformans to environmental signals [0.03%]
利用新的数据资源来定义新型隐球菌对环境信号的反应
Yu Sung Kang,Jeffery Jung,Holly Brown et al.
Yu Sung Kang et al.
Cryptococcus neoformans is an opportunistic fungal pathogen with a polysaccharide capsule that becomes greatly enlarged in the mammalian host and during in vitro growth under host-like conditions. To understand how individual environmental ...
Dominant myosin storage myopathy mutations disrupt striated muscles in Drosophila and the myosin tail-tail interactome of human cardiac thick filaments [0.03%]
肌球蛋白储存肌病的主导突变会破坏果蝇条状肌肉和人类心脏厚丝肌球蛋白尾-尾相互作用组
Meera C Viswanathan,Debabrata Dutta,William A Kronert et al.
Meera C Viswanathan et al.
Myosin storage myopathy (MSM) is a rare skeletal muscle disorder caused by mutations in the slow muscle/β-cardiac myosin heavy chain (MHC) gene. MSM missense mutations frequently disrupt the tail's stabilizing heptad repeat motif. Disease ...
Parental-effect gene-drive elements under partial selfing, or why do Caenorhabditis genomes have hyperdivergent regions? [0.03%]
偏自交条件下父本-母本效应基因驱动元件的扩散，或者为什么线虫基因组有超分化区域？
Matthew V Rockman
Matthew V Rockman
Self-fertile Caenorhabditis nematodes carry a surprising number of Medea elements, alleles that act in heterozygous mothers and cause death or developmental delay in offspring that don't inherit them. At some loci, both alleles in a cross o...
MegaLMM improves genomic predictions in new environments using environmental covariates [0.03%]
利用环境协变量改进 MegaLMM 在新环境下进行基因组预测的能力
Haixiao Hu,Renaud Rincent,Daniel E Runcie
Haixiao Hu
Multi-environment trials (METs) are crucial for identifying varieties that perform well across a target population of environments (TPE). However, METs are typically too small to sufficiently represent all relevant environment-types, and fa...
Drosophila ring chromosomes interact with sisters and homologs to produce anaphase bridges in mitosis [0.03%]
果蝇环形染色体与姐妹染色单体和同源染色体相互作用，在有丝分裂中产生晚期分离桥现象
Ho-Chen Lin,Mary M Golic,Hunter J Hill et al.
Ho-Chen Lin et al.
Ring chromosomes are known in many eukaryotic organisms, including humans. They are typically associated with a variety of maladies, including abnormal development and lethality. Underlying these phenotypes are anaphase chromatin bridges th...
Bingbing Duan,Chenxi Qiu,Steve W Lockless et al.
Bingbing Duan et al.
RNA polymerase II (Pol II) has a highly conserved domain, the trigger loop (TL), that controls transcription fidelity and speed. We previously probed pairwise genetic interactions between residues within and surrounding the TL for the purpo...
Genomic prediction of cereal crop architectural traits using models informed by gene regulatory circuitries from maize [0.03%]
利用玉米基因调控线路信息预测 cereals 种植构造性状的全基因组预测模型研究
Edoardo Bertolini,Mohith Manjunath,Weihao Ge et al.
Edoardo Bertolini et al.
Plant architecture is a major determinant of planting density, which enhances productivity potential for crops per unit area. Genomic prediction is well positioned to expedite genetic gain of plant architectural traits since they are typica...