A tale of two serines: the effects of histone H2A mutations S122A and S129A on chromosome non-disjunction in Saccharomyces cerevisiae [0.03%]
苏氨酸H2A突变体S122A和S129A对假丝酵母染色体分离不整合作用的研究
Stanislav G Kozmin,Margaret Dominska,Robert J Kokoska et al.
Stanislav G Kozmin et al.
Near the C-terminus of histone H2A in the yeast S. cerevisiae, there are two serines (S122 and S129) that are targets of phosphorylation. The phosphorylation of Serine 129 in response to DNA damage is dependent on the Tel1 and Mec1 kinases....
Genomic prediction of heterosis, inbreeding control, and mate allocation in outbred diploid and tetraploid populations [0.03%]
基于基因组预测的异交优势、近交控制及交配分配在二倍体和四倍体中应用研究
Jeffrey B Endelman
Jeffrey B Endelman
Breeders have long appreciated the need to balance selection for short-term genetic gain with maintaining genetic variance for long-term gain. For outbred populations, the method called Optimum Contribution Selection (OCS) chooses parental ...
Acentric chromosome congression and alignment on the metaphase plate via kinetochore-independent forces in Drosophila [0.03%]
斑果蝇无着丝点染色体汇聚和独立于动粒之外的中期板定位现象
Hannah Vicars,Alison Mills,Travis Karg et al.
Hannah Vicars et al.
Chromosome congression and alignment on the metaphase plate involves lateral and microtubule plus-end interactions with the kinetochore. Here we take advantage of our ability to efficiently generate a GFP-marked acentric X chromosome fragme...
Balancing selfing and outcrossing: the genetics and cell biology of nematodes with three sexual morphs [0.03%]
自体受精和异体交配的平衡：具有三种性别形态的线虫的遗传学和细胞生物学
Sally Adams,Sophie Tandonnet,Andre Pires-daSilva
Sally Adams
Trioecy, a rare reproductive system where hermaphrodites, females, and males coexist, is found in certain algae, plants, and animals. Though it has evolved independently multiple times, its rarity suggests it may be an unstable or transitor...
Allopolyploidy expanded gene content but not pangenomic variation in the hexaploid oilseed Camelina sativa [0.03%]
异源多倍化增加了油料作物芸苔素的基因含量但并未增加泛基因组变异
Kevin A Bird,Jordan R Brock,Paul P Grabowski et al.
Kevin A Bird et al.
Ancient whole-genome duplications (WGDs) are believed to facilitate novelty and adaptation by providing the raw fuel for new genes. However, it is unclear how recent WGDs may contribute to evolvability within recent polyploids. Hybridizatio...
The recombination landscape of the barn owl, from families to populations [0.03%]
基因重组在短耳鸮中的遗传图谱：从家庭到种群水平
Alexandros Topaloudis,Tristan Cumer,Eléonore Lavanchy et al.
Alexandros Topaloudis et al.
Homologous recombination is a meiotic process that generates diversity along the genome and interacts with all evolutionary forces. Despite its importance, studies of recombination landscapes are lacking due to methodological limitations an...
Markku Kuismin,Mikko J Sillanp
Markku Kuismin
Gene co-expression networks typically comprise modules and their associated hub genes, which are regulating numerous downstream interactions within the network. Methods for hub screening, as well as data-driven estimation of hub co-expressi...
A path integral approach for allele frequency dynamics under polygenic selection [0.03%]
多基因选择下等位基因频率动态的路径积分方法研究
Nathan W Anderson,Lloyd Kirk,Joshua G Schraiber et al.
Nathan W Anderson et al.
Many phenotypic traits have a polygenic genetic basis, making it challenging to learn their genetic architectures and predict individual phenotypes. One promising avenue to resolve the genetic basis of complex traits is through evolve-and-r...
Saccharomyces Genome Database: Advances in Genome Annotation, Expanded Biochemical Pathways, and Other Key Enhancements [0.03%]
酵母基因数据库：基因注释的改进、生化途径的扩充及其他关键更新功能
Stacia R Engel,Suzi Aleksander,Robert S Nash et al.
Stacia R Engel et al.
Budding yeast (Saccharomyces cerevisiae) is the most extensively characterized eukaryotic model organism and has long been used to gain insight into the fundamentals of genetics, cellular biology, and the functions of specific genes and pro...
A single mutation G454A in the P450 CYP9K1 drives pyrethroid resistance in the major malaria vector Anopheles funestus reducing bed net efficacy [0.03%]
蚊子中产生扬基素耐药性的单一突变降低了蚊帐的效果
Carlos S Djoko Tagne,Mersimine F M Kouamo,Magellan Tchouakui et al.
Carlos S Djoko Tagne et al.
Metabolic mechanisms conferring pyrethroid resistance in malaria vectors are jeopardizing the effectiveness of insecticide-based interventions, and identification of their markers is a key requirement for robust resistance management. Here,...